Paid Clinical Trials in South Carolina

South Carolina has 1,226 paid clinical trials enrolling now across cities including Charleston, Greenville and Columbia. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 31, 2026.

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1,109 clinical trials

Safety and Preliminary Effectiveness of BNT317, an Investigational Therapy for Advanced Solid Tumors

for Advanced Solid Tumor

Sites in Charleston +6 more locations

Sponsor: BioNTech SE

Sex: All·Age: 18+

Code: NCT06750185·Phase 1·Recruiting·Listed Dec 2024

Apply to this trial

Enzalutamide Implants (Enolen) in Patients With Prostate Cancer

for Prostate Adenocarcinoma

Sites in Myrtle Beach +6 more locations

Sponsor: Alessa Therapeutics Inc.

Sex: Male·Age: 21+

Code: NCT06257693·Phase 1·Recruiting·Listed Feb 2024

Apply to this trial

X-ray Psoralen Activated Cancer Therapy in Head and Neck, Breast, Sarcoma and Melanoma

for Advanced Solid Tumor Cancer

Sites in Greenville +3 more locations

Sponsor: Immunolight, LLC

Sex: All·Age: 18+

Code: NCT04389281·Phase 1·Recruiting·Listed May 2020

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CraniSeal Post Approval Study

for Leak, Cerebrospinal Fluid

Sites in Greenville +6 more locations

Sponsor: Pramand LLC

Sex: All·Age: 18+

Code: NCT06406790·Phase 4·Recruiting·Listed May 2024

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A Study to Investigate APL-5125 in Adults With Advanced Solid Tumors

for Colorectal Cancer

Sites in Charleston +6 more locations

Sponsor: Apollo Therapeutics Ltd

Sex: All·Age: 18+

Code: NCT06399757·Phase 1, Phase 2·Recruiting·Listed May 2024

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A Safety and Efficacy Study of HCB101, Fc-fusion Protein Targeting SIRPα-CD47 Pathway, in Solid or Hematological Tumors

for Advanced Solid Tumor

Sites in Greenville +3 more locations

Sponsor: FBD Biologics Limited

Sex: All·Age: 18+

Code: NCT05892718·Phase 1·Recruiting·Listed Jun 2023

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STimulation to Activate RespIration

for ARDS (Moderate or Severe)

Sites in Columbia +5 more locations

Sponsor: Lungpacer Medical Inc.

Sex: All·Age: 18+

Code: NCT06832306·Recruiting·Listed Feb 2025

Apply to this trial

Access Cannulation Trial II

for Dialysis

Sites in Orangeburg +7 more locations

Sponsor: Voyager Biomedical

Sex: All·Age: 18+

Code: NCT05490225·Recruiting·Listed Aug 2022

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Solv Multi-Pass Hemodialysis System In-Center Clinical Study

for End Stage Renal Disease

1 location in Greenville

Sponsor: Mozarc Medical US LLC

Sex: All·Age: 18+

Code: NCT07216885·Recruiting·Listed Oct 2025

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First in Human, Dose Escalation Study of AN4005

for Advanced Solid Tumor

Sites in Greenville +3 more locations

Sponsor: Adlai Nortye Biopharma Co., Ltd.

Sex: All·Age: 18+

Code: NCT04999384·Phase 1·Recruiting·Listed Aug 2021

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Pharmacokinetics, Safety, and Tolerability Study of GOPRELTO® Nasal Solution and NUMBRINO™ Nasal Solution

for ENT Disorder

Sites in Columbia & Lugoff

Sponsor: Noden Pharma

Sex: All·Age: 12 - 18

Code: NCT04792034·Phase 3·Recruiting·Listed Mar 2021

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ViewFlex X ICE First-in-Human Study

for Cardiac Arrhythmias

Sites in Charleston +7 more locations

Sponsor: Abbott Medical Devices

Sex: All·Age: 18+

Code: NCT06772493·Recruiting·Listed Jan 2025

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Auryon Atherectomy System With Standard Balloon Angioplasty Versus Standard Balloon Angioplasty Alone

for Peripheral Arterial Diseases

Sites in Greenville +8 more locations

Sponsor: Angiodynamics, Inc.

Sex: All·Age: All ages

Code: NCT06777901·Phase 4·Recruiting·Listed Jan 2025

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Vitaccess Real MG Registry

for Myasthenia Gravis

Sites in Charleston +5 more locations

Sponsor: Vitaccess Ltd

Sex: All·Age: 18+

Code: NCT06064461·Recruiting·Listed Oct 2023

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Analysis of Velmanase Alfa (Lamzede®)'s Effects in the Body of Children With Alpha-Mannosidosis Under the Age 3

for Alpha-Mannosidosis

Sites in Greenwood +1 more location

Sponsor: Chiesi Farmaceutici S.p.A.

Sex: All·Age: Up to 3

Code: NCT06184503·Recruiting·Listed Dec 2023

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A Multicenter, Postmarket Surveillance Study of Subjects With the Canary canturioTM te Tibial Extension

for Knee Osteoarthritis

Sites in Spartanburg +6 more locations

Sponsor: Canary Medical

Sex: All·Age: 18+

Code: NCT06040827·Recruiting·Listed Sep 2023

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Saline Enhanced Radiofrequency (SERF) Needle Ablation for Refractory VT

for Refractory Ventricular Tachycardia

Sites in Charleston +4 more locations

Sponsor: Thermedical, Inc.

Sex: All·Age: 18+

Code: NCT05337241·Recruiting·Listed Apr 2022

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Patient Specific Talus Spacer Post Approval Study

for Avascular Necrosis of the Talus

Sites in Charleston +5 more locations

Sponsor: Paragon 28

Sex: All·Age: 21+

Code: NCT05364606·Recruiting·Listed May 2022

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FK-PC101 as Adjuvant Therapy for Men With High-Risk Prostate Cancer

for Prostate Cancer (Adenocarcinoma)

Sites in Myrtle Beach +1 more location

Sponsor: Cellvax Therapeutics Inc

Sex: Male·Age: All ages

Code: NCT06636682·Phase 2·Recruiting·Listed Oct 2024

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Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

for Arrhythmogenic Right Ventricular Cardiomyopathy

Sites in Charleston +7 more locations

Sponsor: Tenaya Therapeutics

Sex: All·Age: 14 - 65

Code: NCT06311708·Recruiting·Listed Mar 2024

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A Post-Market Domestic (US) and International Data Collection to Assess the Truliant Knee System

for Knee Arthroplasty, Total

Sites in Charleston +4 more locations

Sponsor: Exactech

Sex: All·Age: 18+

Code: NCT05653102·Recruiting·Listed Dec 2022

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OurRelationship-S: A Digital Relationship-Strengthening Program for Couples Experiencing Substance Misuse

for Relationship Conflict

Sites in Lexington +4 more locations

Sponsor: OurRelationship

Sex: All·Age: 18+

Code: NCT07159633·Recruiting·Listed Sep 2025

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The Impact of MeMed BV® on Management of Patients With Suspected Lower Respiratory Tract Infections (LRTI) in the Emergency Department (ED) and Urgent Care Center (UCC) ("JUPITER" TRIAL)

for Lower Respiratory Tract Infection

Sites in Charleston +7 more locations

Sponsor: MeMed Diagnostics Ltd.

Sex: All·Age: 18 - 99

Code: NCT05762302·Recruiting·Listed Mar 2023

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A Study to Evaluate the SENSE Device's Ability to Detect TBI

for Traumatic Brain Injury

Sites in Charleston +5 more locations

Sponsor: Sense Diagnostics, LLC

Sex: All·Age: 22+·Accepts healthy volunteers

Code: NCT06828107·Recruiting·Listed Feb 2025

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A Study of KB408 for the Treatment of Alpha-1 Antitrypsin Deficiency

for Alpha 1-Antitrypsin Deficiency

Sites in Charleston +2 more locations

Sponsor: Krystal Biotech, Inc.

Sex: All·Age: 18 - 70

Code: NCT06049082·Phase 1·Recruiting·Listed Sep 2023

Apply to this trial

Digital Wellness Nurse - FIT Families: Virtual Family Intervention for Adolescent Obesity

for Obese Children and Adolescents

1 location in Charleston

Sponsor: Machine and Human Interaction

Sex: All·Age: 12 - 17

Code: NCT07087808·Recruiting·Listed Jul 2025

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UC-MSC Cell Therapy Study for Systemic Lupus Erythematosus (SLE) Patients

for SLE

1 location in Charleston

Sponsor: LiveKidney.Bio

Sex: All·Age: 18 - 75

Code: NCT06737380·Phase 1·Recruiting·Listed Dec 2024

Apply to this trial

Pounce™ Thrombectomy System Retrospective Registry

for Peripheral Arterial Disease

Sites in Greenville +6 more locations

Sponsor: SurModics, Inc.

Sex: All·Age: 18+

Code: NCT05868161·Recruiting·Listed May 2023

Apply to this trial

Pulse Endovascular ReperFUSION for Acute Ischemic Stroke

for Acute Ischemic Stroke AIS

1 location in Columbia

Sponsor: Euphrates Vascular, Inc.

Sex: All·Age: 18 - 85

Code: NCT06052969·Recruiting·Listed Sep 2023

Apply to this trial

Project Mountain - Comparing SpO2 and SaO2 for Accuracy

for SpO2

Sites in Charleston +4 more locations

Sponsor: Philips Clinical & Medical Affairs Global

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06372106·Recruiting·Listed Apr 2024

Apply to this trial

Encore PFO Closure Device - The PerFOrm Trial

for Patent Foramen Ovale

Sites in Charleston +7 more locations

Sponsor: Encore Medical Inc.

Sex: All·Age: 18 - 60

Code: NCT05537753·Recruiting·Listed Sep 2022

Apply to this trial

Longitudinal Bladder Cancer Study for Tumour Recurrence

for Urothelial Bladder Cancer

Sites in Charleston +5 more locations

Sponsor: Pacific Edge Limited

Sex: All·Age: 18+

Code: NCT05080998·Recruiting·Listed Oct 2021

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A Prospective Real World Evidence Study (PROWES) for Concordance Rate of Blood-based 3D Genome Conformation Mapping (Episwitch CiRT®) to Identify Likelihood of Response and Actual Response Rates to PD-(L)-1 Checkpoint Inhibitors Across Multiple Oncological Indications.

for Cancer

Sites in Rock Hill +2 more locations

Sponsor: Oxford Biodynamics Inc.

Sex: All·Age: 18+

Code: NCT06635954·Recruiting·Listed Oct 2024

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Impact of Capturing Ictal Events With Ultra-long-term Ambulatory EEG Monitoring With Remote EEG Monitoring System.

for Epilepsy

Sites in Charleston +1 more location

Sponsor: Epitel, Inc.

Sex: All·Age: 18 - 70

Code: NCT06027749·Recruiting·Listed Sep 2023

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Mindful Walking Neural Correlates of Executive Function in SC Older Adults at Risk of Dementias

for Older Adults With Elevated Dementia Risk

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 60+·Accepts healthy volunteers

Code: NCT07638046·Phase 2·Recruiting·Listed Jun 10, 2026

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Digitally Enhanced Stepped-Care for Depression in Primary Care

for Depression

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07634705·Recruiting·Listed Jun 9, 2026

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Outcomes Associated With Tirbanibulin for Large Field Application on the Face in the U.S (CLEAR)

for Actinic Keratosis (AK)

Sites in Charleston +1 more location

Sponsor: Avant Health LLC

Sex: All·Age: 18+

Code: NCT07657988·Recruiting·Listed Jun 18, 2026

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Recovery From Post-Stroke Aphasia With rTMS Targeting Left or Right Anterior Temporal Lobe

for Stroke

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 18+

Code: NCT07608588·Recruiting·Listed May 2026

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Efficacy of Center-based Childcare to Mitigate Unhealthy Weight Gain in Preschoolers From Low-income Households During the Summer

for Obesity & Overweight

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 3 - 5·Accepts healthy volunteers

Code: NCT07583459·Recruiting·Listed May 2026

Apply to this trial

A Pragmatic Clinical Trial of the WE BEAT Well-Being Education Program in Adolescent Congenital Heart Disease: WE BEAT CHD Study

for Patient-Reported Outcome Measures (PROMs)

Sites in Charleston +13 more locations

Sponsor: Carelon Research

Sex: All·Age: 12 - 17

Code: NCT07525843·Recruiting·Listed Apr 2026

Apply to this trial