Paid Clinical Trials in South Carolina

South Carolina has 1,217 paid clinical trials enrolling now across cities including Charleston, Greenville and Columbia. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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1,101 clinical trials

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Neuromodulation + Prolonged Exposure Therapy: Evaluation of a Technology-Enhanced, Integrated Treatment for Pain and PTSD

for Chronic Pain

1 location in Charleston

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 21+

Code: NCT07116109·Recruiting·Listed Aug 2025

Apply to this trial

NeoCARD: Anthracycline-Free Neoadjuvant Chemoimmunotherapy in Triple-Negative Breast Cancer Patients

for Triple Negative Breast Cancer

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06845319·Phase 2·Recruiting·Listed Feb 2025

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Methadone in TKA for Post-op Pain and Opioid Reduction

for Post Operative Pain

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 75

Code: NCT07226076·Phase 3·Recruiting·Listed Nov 2025

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Establishing Mobile Transcranial Magnetic Stimulation

for Treatment Resistant Major Depression

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 22 - 80

Code: NCT06748209·Phase 4·Recruiting·Listed Dec 2024

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A Culturally-Tailored Mobile Health and Social Media Physical Activity Intervention for Improving Physical Activity in Hispanic or Latino/Latina Adolescent and Young Adult Childhood Cancer Survivors, Walking Juntos Study

for Hematopoietic and Lymphatic System Neoplasm

Sites in Greenville +75 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 15 - 20

Code: NCT06410209·Phase 2·Recruiting·Listed May 2024

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S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

for Cardiotoxicity

Sites in Greenville +143 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT03418961·Phase 3·Recruiting·Listed Feb 2018

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Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS

for Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)

Sites in Charleston +31 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 1 Day - 17

Code: NCT05267821·Phase 2, Phase 3·Recruiting·Listed Mar 2022

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Optimizing a Remote-based Physical Activity Intervention for Adults With Total Knee Replacement

for Knee Replacement

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 18+

Code: NCT06768762·Recruiting·Listed Jan 2025

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Advanced Fibrosis Detection for MASLD in Primary Care

for Metabolic Dysfunction-associated Steatotic Liver Disease

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07159386·Recruiting·Listed Sep 2025

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Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC

for Oropharyngeal Squamous Cell Carcinoma

Sites in North Charleston +1 more location

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT04564989·Recruiting·Listed Sep 2020

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Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial

for Metastatic Clear Cell Renal Cell Carcinoma

Sites in Charleston +339 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04510597·Phase 3·Recruiting·Listed Aug 2020

Apply to this trial

Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and PTSD

for Posttraumatic Stress Disorder

Sites in Charleston +1 more location

Sponsor: Texas A&M University

Sex: All·Age: 18+

Code: NCT05959434·Phase 2·Recruiting·Listed Jul 2023

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Randomized Trial of Tele Vs. Clinic TF-CBT in Puerto Rico

for Post-Traumatic Stress Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 7 - 18

Code: NCT06332209·Recruiting·Listed Mar 2024

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Dichoptic Treatment for Amblyopia in Children 4 to 7 Years of Age

for Amblyopia

Sites in Columbia, Mt. Pleasant +71 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 4 - 7

Code: NCT06380517·Phase 3·Recruiting·Listed Apr 2024

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A Randomized Trial to Evaluate Sequential vs Simultaneous Patching

for Amblyopia

Sites in Columbia +67 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 3 - 13

Code: NCT04378790·Phase 3·Recruiting·Listed May 2020

Apply to this trial

Stroke Thrombectomy and Aneurysm Registry

for Stroke

Sites in Charleston +53 more locations

Sponsor: Medical University of South Carolina

Sex: All·Age: 1 - 120

Code: NCT04994756·Recruiting·Listed Aug 2021

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Safety and Efficacy of Mesenchymal Stem Cells Associated With Chronic Pancreatitis Pain

for Chronic Pancreatitis

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 75

Code: NCT06205342·EARLY_Phase 1·Recruiting·Listed Jan 2024

Apply to this trial

RTMS Targets Neural Circuits for Smoking Cessation

for Tobacco Use

2 locations in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 22 - 70·Accepts healthy volunteers

Code: NCT04903028·Recruiting·Listed May 2021

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EMPOWER: Effects of Weight Loss and Exercise Post-stroke

for Obesity

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 35 - 85

Code: NCT05901675·Recruiting·Listed Jun 2023

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Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

for Castration Levels of Testosterone

Sites in Charleston, Greenville +292 more locations

Sponsor: SWOG Cancer Research Network

Sex: Male·Age: 18+

Code: NCT03678025·Phase 3·Recruiting·Listed Sep 2018

Apply to this trial

iAmHealthy Clinical Practice Guideline (CPG)

for Pediatric Obesity

Sites in Charleston +3 more locations

Sponsor: University of Kansas Medical Center

Sex: All·Age: 6 - 11

Code: NCT06888011·Recruiting·Listed Mar 2025

Apply to this trial

Cannabis Reduction and Functional Outcomes

for Cannabis Use Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07218471·Recruiting·Listed Oct 2025

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Black and African Americans Connections to Parkinson's Disease (BLAAC PD)

for Parkinson Disease

Sites in Charleston +10 more locations

Sponsor: Michael J. Fox Foundation for Parkinson's Research

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06719583·Recruiting·Listed Dec 2024

Apply to this trial

HVIP Outcomes and Stakeholder Insights

for Firearm Injury

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 16+·Accepts healthy volunteers

Code: NCT06582953·Recruiting·Listed Sep 2024

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A Brief Intervention for Cannabis Use

for Cannabis Use Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 25

Code: NCT06395389·Recruiting·Listed May 2024

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Novel Cellular Therapy for the Treatment of Pain Associated With Chronic Pancreatitis

for Chronic Pancreatitis

1 location in Charleston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 75

Code: NCT05925036·Phase 1·Recruiting·Listed Jun 2023

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Dichoptic Treatment for Amblyopia in Children 8 to 12 Years of Age

for Amblyopia

Sites in Mt. Pleasant +57 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 8 - 12

Code: NCT06524882·Phase 3·Recruiting·Listed Jul 2024

Apply to this trial

Cannabis-Tobacco Co-Use Treatment Study

for Tobacco Use Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06883162·Phase 3·Recruiting·Listed Mar 2025

Apply to this trial

Dose Response of Exercise for Arthritis Management

for Arthritis

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 18+

Code: NCT06880653·Recruiting·Listed Mar 2025

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Advancing Couple and Family Alcohol Treatment Through Patient-Oriented Research and Mentorship

for Alcohol Use Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 21+

Code: NCT05786157·Recruiting·Listed Mar 2023

Apply to this trial

Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT for Long COVID)

for Smell Dysfunction

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 65

Code: NCT05855369·Phase 2, Phase 3·Recruiting·Listed May 2023

Apply to this trial

Study Adding Drugs to Usual Treatment for Large B-Cell Lymphoma That Returned or Did Not Respond to Treatment

for Grade 3b Follicular Lymphoma

Sites in Charleston +98 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05890352·Phase 2·Recruiting·Listed Jun 2023

Apply to this trial

MEP Up-conditioning to Target Corticospinal Plasticity

for Spinal Cord Injury

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06989905·EARLY_Phase 1·Recruiting·Listed May 2025

Apply to this trial

Telerehabilitation for Aphasia (TERRA)

for Aphasia

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 21 - 80

Code: NCT04682223·Recruiting·Listed Dec 2020

Apply to this trial

MPFC Theta Burst Stimulation as a Treatment Tool for Alcohol Use Disorder: Effects on Drinking and Incentive Salience

for Alcohol Use Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 21 - 65

Code: NCT04998916·Recruiting·Listed Aug 2021

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Transcranial Magnetic Stimulation for MCI

for Mild Cognitive Impairment

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 60 - 85

Code: NCT05992831·Recruiting·Listed Aug 2023

Apply to this trial

Vitamin D for Prostate Endocrine Therapy

for Stage I Prostate Cancer AJCC v8

Sites in Greenville, Spartanburg +49 more locations

Sponsor: University of Rochester

Sex: Male·Age: 50+

Code: NCT05838716·Phase 3·Recruiting·Listed May 2023

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A Study of a Novel EEG Neurofeedback System for PTSD Treatment

for Stress Disorders, Post-Traumatic

Sites in Charleston +5 more locations

Sponsor: Foundation for Atlanta Veterans Education and Research, Inc.

Sex: All·Age: 18 - 65

Code: NCT06770998·Recruiting·Listed Jan 2025

Apply to this trial

Preoperative 5-Day Radiotherapy for Soft Tissue Sarcoma

for Soft Tissue Sarcoma

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06905132·Phase 2·Recruiting·Listed Apr 2025

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Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM)

for Cystic Fibrosis (CF)

Sites in Charlestone +17 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 12+

Code: NCT06837181·Recruiting·Listed Feb 2025

Apply to this trial