Paid Clinical Trials in South Carolina

South Carolina has 1,226 paid clinical trials enrolling now across cities including Charleston, Greenville and Columbia. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 31, 2026.

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Healthy volunteers only

1,109 clinical trials

Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection

for Shiga Toxin-Producing Escherichia Coli (E. Coli) Infection

Sites in Charleston +21 more locations

Sponsor: University of Calgary

Sex: All·Age: 9 Months - 21

Code: NCT05219110·Recruiting·Listed Feb 2022

Apply to this trial

Induction in the Dark

for Anesthesia Induction

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 2 - 6

Code: NCT06144177·Phase 4·Recruiting·Listed Nov 2023

Apply to this trial

CBD for Breast Cancer Primary Tumors

for Breast Cancer

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06148038·Phase 1·Recruiting·Listed Nov 2023

Apply to this trial

Social Functioning in Opioid Use Disorder

for Opioid Use Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07044466·Recruiting·Listed Jul 2025

Apply to this trial

SUPPORT-T in Patients With Progressive Pulmonary Fibrosis and Their Caregivers

for Progressive Pulmonary Fibrosis

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07269262·Recruiting·Listed Dec 2025

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Pediatric Precision Laboratory Advanced Neuroblastoma Therapy

for Neuroblastoma

Sites in Charleston +19 more locations

Sponsor: Giselle Sholler

Sex: All·Age: Up to 22

Code: NCT02559778·Phase 2·Recruiting·Listed Sep 2015

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Examining Whether Project Support Works

for Parent-Child Relations

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 6 - 13

Code: NCT06963554·Recruiting·Listed May 2025

Apply to this trial

Emotional Recovery Post-Stroke

for Stroke

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 21+

Code: NCT06782321·Recruiting·Listed Jan 2025

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Safety Study of Unlicensed IND Cord Blood Units Manufactured by the National Cord Blood Program for Unrelated Transplantation

for Infusion Reactions

Sites in Charleston +59 more locations

Sponsor: New York Blood Center

Sex: All·Age: All ages

Code: NCT01656603·Phase 2·Recruiting·Listed Aug 2012

Apply to this trial

Methadone in THA for Post-op Pain and Opioid Reduction

for Post Operative Pain

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 75

Code: NCT07227064·Phase 3·Recruiting·Listed Nov 2025

Apply to this trial

Brain Metastases in Greater Size - Hypofractionated Options Trial (BIGSHOT)

for Brain Metastases

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07227610·Phase 2·Recruiting·Listed Nov 2025

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Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma

for Embryonal Rhabdomyosarcoma

Sites in Greenville, Columbia +161 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT05304585·Phase 3·Recruiting·Listed Mar 2022

Apply to this trial

RaDIANT Health Systems Intervention

for End Stage Renal Disease (ESRD)

Sites in Lancaster +4 more locations

Sponsor: Indiana University

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07033117·Recruiting·Listed Jun 2025

Apply to this trial

DFMO as Maintenance Therapy for Molecular High/Very High Risk and Relapsed Medulloblastoma

for Medulloblastoma

Sites in Charleston +22 more locations

Sponsor: Giselle Sholler

Sex: All·Age: Up to 21

Code: NCT04696029·Phase 2·Recruiting·Listed Jan 2021

Apply to this trial

E-cigarette Cessation in Adults Who Co-use Cannabis

for Nicotine Dependence

Sites in Charleston, Lancaster & Pickens

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT06688539·Phase 4·Recruiting·Listed Nov 2024

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Methadone in TKA for Post-op Pain and Opioid Reduction

for Post Operative Pain

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 75

Code: NCT07226076·Phase 3·Recruiting·Listed Nov 2025

Apply to this trial

Prospective Non-Interventional Study Comparing Osimertinib +/- Chemotherapy for EGFR-Mutated NSCLC Patients

for Non Small Cell Lung Cancer

Drug: Osimertinib

Sites in Bluffton, Hilton Head Island +144 more locations

Sponsor: PrECOG, LLC.

Sex: All·Age: 18+

Code: NCT06538038·Recruiting·Listed Aug 2024

Apply to this trial

The SNAP Tool for Head and Neck Cancer Survivor-Caregiver Dyads

for Head and Neck Cancer

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT05811936·Recruiting·Listed Apr 2023

Apply to this trial

NEPTUNE Match Study

for Nephrotic Syndrome in Children

Sites in Charlotte +15 more locations

Sponsor: University of Michigan

Sex: All·Age: 1 - 80

Code: NCT04571658·Recruiting·Listed Oct 2020

Apply to this trial

Development and Evaluation of a Virtual Reality Tool for At-Risk Trauma-Exposed Young People

for Substance Use Disorders

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 15 - 30·Accepts healthy volunteers

Code: NCT05816083·Recruiting·Listed Apr 2023

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A Randomized Crossover Trial of Bright Light Therapy in Crohn's Disease on Intestinal Barrier Homeostasis

for Inflammatory Bowel Disease

Sites in Charleston +1 more location

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT05579392·Recruiting·Listed Oct 2022

Apply to this trial

ERP to Improve Functioning in Veterans With OCD

for Obsessive Compulsive Disorder (OCD)

Sites in Charleston +18 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05240924·Recruiting·Listed Feb 2022

Apply to this trial

Education & Mentorship of Advanced Practice Providers to Increase Community-based Research Within the NCORP Network, COACH-APP Trial

for Other

Sites in Greenville, Spartanburg +29 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06904391·Recruiting·Listed Apr 2025

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Evaluating NALIRIFOX vs Modified Gemcitabine, Nab-Paclitaxel and Cisplatin in Patients With Locally Advanced and Metastatic Pancreatic Adenocarcinoma

for Metastatic Pancreatic Adenocarcinoma

2 locations in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07076212·Phase 2·Recruiting·Listed Jul 2025

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Health Education Approach to Lung Screening

for Lung Cancer

Sites in Charleston +2 more locations

Sponsor: Virginia Commonwealth University

Sex: All·Age: 50 - 80·Accepts healthy volunteers

Code: NCT06070870·Recruiting·Listed Oct 2023

Apply to this trial

Train Your Brain Fitness SC: An Exercise Intervention for People With Cognitive Impairments

for Mild-moderate Cognitive Impairment

Sites in Columbia & Sumter

Sponsor: University of South Carolina

Sex: All·Age: 18+

Code: NCT06799429·Recruiting·Listed Jan 2025

Apply to this trial

tFUS Induced Transient Scotoma for Individual Dosing

for Healthy

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT06426498·Recruiting·Listed May 2024

Apply to this trial

Cognitive Decline Following Deep Brain Stimulation

for Parkinson Disease

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05822388·Recruiting·Listed Apr 2023

Apply to this trial

Neuromodulation + Prolonged Exposure Therapy: Evaluation of a Technology-Enhanced, Integrated Treatment for Pain and PTSD

for Chronic Pain

1 location in Charleston

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 21+

Code: NCT07116109·Recruiting·Listed Aug 2025

Apply to this trial

Cannabis Reduction and Functional Outcomes

for Cannabis Use Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07218471·Recruiting·Listed Oct 2025

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IMPACT (IMproving Proactive Approaches for Cancer Survivors' Mental Health Treatment)

for Depression

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06582784·Recruiting·Listed Sep 2024

Apply to this trial

Accelerated iTBS for Post Partum Depression

for Post Partum Depression

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: Female·Age: 18 - 50

Code: NCT03417960·Recruiting·Listed Jan 2018

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Advanced Fibrosis Detection for MASLD in Primary Care

for Metabolic Dysfunction-associated Steatotic Liver Disease

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07159386·Recruiting·Listed Sep 2025

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Longitudinal Screening for Financial Hardship to Improve Outcomes in Patients With Advanced Cancer

for Advanced Cancer

Sites in Spartanburg +5 more locations

Sponsor: Alliance Foundation Trials, LLC.

Sex: All·Age: 21+

Code: NCT06963723·Recruiting·Listed May 2025

Apply to this trial

PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes

for Type2Diabetes

Sites in Charleston, Orangeburg +34 more locations

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 40 - 80

Code: NCT05390892·Phase 4·Recruiting·Listed May 2022

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Closed-loop rTMS-EEG During Visuomotor Integration.

for Visuomotor Skills

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07249801·Recruiting·Listed Nov 2025

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Weekly Isotretinoin vs Tetracycline for Moderate Acne

for Acne Vulgaris

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 12+·Accepts healthy volunteers

Code: NCT06225570·EARLY_Phase 1·Recruiting·Listed Jan 2024

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Single Versus Dual Implant Fixation of Distal Femur Fractures

for Articular Fractures

Sites in Greenville +15 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06286670·Recruiting·Listed Feb 2024

Apply to this trial

Platform of Randomized Adaptive Clinical Trials in Critical Illness

for Respiratory Insufficiency

Sites in Charleston +25 more locations

Sponsor: University Health Network, Toronto

Sex: All·Age: 18+

Code: NCT05440851·Recruiting·Listed Jul 2022

Apply to this trial

Anesthetics and Analgesics in Children

for Anesthesia

Sites in Charleston +2 more locations

Sponsor: Chi Dang Hornik

Sex: All·Age: 0 - 17

Code: NCT03427736·Recruiting·Listed Feb 2018

Apply to this trial