Paid Clinical Trials in South Carolina

South Carolina has 1,277 paid clinical trials enrolling now across cities including Charleston, Greenville and Columbia. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 16, 2026.

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1,277 clinical trials

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Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations

for Non-Small Cell Lung Cancer

Drug: Rilvegostomig

63 locations incl. Anchorage

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06357533·Phase 3·Recruiting

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Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Adults With Moderate to Severe Acne

for Acne

79 locations incl. Scottsdale

Sponsor: Sanofi Pasteur, a Sanofi Company

Sex: All·Age: 18 - 45

Code: NCT06316297·Phase 1, Phase 2·Recruiting

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SMYLS Multi-site Trial

for Sickle Cell Disease

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 14 - 21·Accepts healthy volunteers

Code: NCT06035939·Recruiting

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Project Mountain - Comparing SpO2 and SaO2 for Accuracy

for SpO2

5 locations incl. Phoenix

Sponsor: Philips Clinical & Medical Affairs Global

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06372106·Recruiting

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A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)

for Non Small Cell Lung Cancer

49 locations incl. Little Rock

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06312137·Phase 3·Recruiting

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A Study Evaluating the Safety and Efficacy of Inhaled AP01 in Participants With Progressive Pulmonary Fibrosis

for Pulmonary Fibrosis

59 locations incl. Birmingham

Sponsor: Avalyn Pharma Inc.

Sex: All·Age: 18+

Code: NCT06329401·Phase 2·Recruiting

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Clinical Safety and Efficacy of the VDyne Transcatheter Tricuspid Valve Replacement System for the Treatment of Tricuspid Regurgitation ( VISTA-US)

for Tricuspid Regurgitation

10 locations incl. Los Angeles

Sponsor: VDyne, Inc.

Sex: All·Age: 18+

Code: NCT05848284·Recruiting

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Comparing TBT to Disorder-Specific Psychotherapy in Veterans With Social Anxiety Disorder

for Social Anxiety Disorder

1 location in Charleston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 80

Code: NCT05858346·Recruiting

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Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and PTSD

for Posttraumatic Stress Disorder

2 locations incl. Charleston

Sponsor: Texas A&M University

Sex: All·Age: 18+

Code: NCT05959434·Phase 2·Recruiting

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Copper Cu 64 PSMA I&T PET Imaging in Men With Newly Diagnosed Prostate Cancer

for Prostate Cancer

44 locations incl. Homewood

Sponsor: Curium US LLC

Sex: Male·Age: 18+

Code: NCT06235151·Phase 3·Recruiting

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Study of Ravulizumab in Immunoglobulin A Nephropathy (IgAN)

for Immunoglobulin A Nephropathy

46 locations incl. Alabaster

Sponsor: Alexion Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06291376·Phase 3·Recruiting

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A Study With Tovorafenib (DAY101) as a Treatment Option for Progressive, Relapsed, or Refractory Langerhans Cell Histiocytosis

for Recurrent Langerhans Cell Histiocytosis

104 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 180 Days - 22

Code: NCT05828069·Phase 2·Recruiting

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A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse

for Cigarette Smoking

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT06118502·Recruiting

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The REBALANCE Study - a Prospective, Multicenter, Randomized, Pivotal Study of the May Health System

for Polycystic Ovary Syndrome

24 locations incl. Encino

Sponsor: May Health

Sex: Female·Age: 18 - 40

Code: NCT06206746·Recruiting

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Efficacy and Safety Study of OATD-01 in Patients With Active Pulmonary Sarcoidosis

for Pulmonary Sarcoidosis

7 locations incl. Birmingham

Sponsor: Molecure S.A.

Sex: All·Age: 18+

Code: NCT06205121·Phase 2·Recruiting

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A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma

for Neoplasms, Head and Neck

Drug: Dostarlimab

36 locations incl. Jonesboro

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT06256588·Phase 3·Recruiting

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Evaluation of SPN-812 (Viloxazine Extended-release Capsule) in Preschool-age Children With ADHD

for Attention-Deficit/Hyperactivity Disorder

47 locations incl. Saraland

Sponsor: Supernus Pharmaceuticals, Inc.

Sex: All·Age: 48 Months - 69 Months

Code: NCT04781140·Phase 4·Recruiting

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Rural COPD E-Visit Study

for Smoking Cessation

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 40+·Accepts healthy volunteers

Code: NCT06236347·Enrolling By Invitation

Strategy for Improving Stroke Treatment Response

for Ischemic Stroke

52 locations incl. Birmingham

Sponsor: Translational Sciences, Inc.

Sex: All·Age: 18+

Code: NCT05948566·Phase 2·Recruiting

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An Efficacy and Safety Study of Intravenous Anifrolumab to Treat Systemic Lupus Erythematosus in Pediatric Participants

for Systemic Lupus Erythematosus

22 locations incl. Phoenix

Sponsor: AstraZeneca

Sex: All·Age: 5 - 17

Code: NCT05835310·Phase 3·Recruiting

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A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis)

for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASH) / Nonalcoholic Steatohepatitis (NASH) With Fibrosis

141 locations incl. Birmingham

Sponsor: 89bio, Inc.

Sex: All·Age: 18 - 80

Code: NCT06318169·Phase 3·Recruiting

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An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan Versus Observation in PSMA Positive OMPC.

for Oligometastatic Prostate Cancer (OMPC)

41 locations incl. Fayetteville

Sponsor: Novartis Pharmaceuticals

Sex: Male·Age: 18 - 100

Code: NCT05939414·Phase 3·Recruiting

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T-reg Function Changes: a Novel Immune Regulatory Effect Underlying Benefit of Statin Use on Lethal Prostate Cancer

for Prostate Cancer

2 locations incl. Atlanta

Sponsor: Medical University of South Carolina

Sex: Male·Age: 18+

Code: NCT05586360·Phase 2·Recruiting

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Heated Intraperitoneal Chemotherapy Followed by Niraparib for Ovarian, Primary Peritoneal and Fallopian Tube Cancer

for Stage III Ovarian Cancer

Drug: Niraparib

59 locations incl. Duarte

Sponsor: GOG Foundation

Sex: Female·Age: 18+

Code: NCT05659381·Phase 3·Recruiting

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A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events

for Diabetes Mellitus, Type 2

124 locations incl. Chandler

Sponsor: Cleerly, Inc.

Sex: All·Age: 55+·Accepts healthy volunteers

Code: NCT06112418·Recruiting

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Galactagogue Use in Lactating Women With Low Milk Supply

for Breast Milk Expression

1 location in Rock Hill

Sponsor: Winthrop University

Sex: Female·Age: 18 - 40·Accepts healthy volunteers

Code: NCT05398367·Recruiting

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A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease

for Crohn's Disease

Drug: TAK-279

29 locations incl. Los Angeles

Sponsor: Takeda

Sex: All·Age: 18 - 75

Code: NCT06233461·Phase 2·Recruiting

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Advancing Couple and Family Alcohol Treatment Through Patient-Oriented Research and Mentorship

for Alcohol Use Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 21+

Code: NCT05786157·Recruiting

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Healthy Kids Beyond the Bell: Investigating the Impact of After-School and Summer Programs

for Health Status Disparities

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 5 - 12·Accepts healthy volunteers

Code: NCT05880901·Phase 2·Recruiting

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Determining the Optimal Amount of Structured Environments for Healthy Kids

for Health Status Disparities

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 5 - 12·Accepts healthy volunteers

Code: NCT06158594·Phase 2·Recruiting

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Cognitive Training for Cancer Related Cognitive Impairment in Breast Cancer Survivors

for Breast Cancer

673 locations incl. Anchorage

Sponsor: NRG Oncology

Sex: All·Age: 18 - 100

Code: NCT05896189·Recruiting

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A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab on Background Topical Corticosteroids Therapy in Participants Aged 12 Years and Older With Moderate-to-severe AD Who Have Had an Inadequate Response to Prior Biologic Therapy or an Oral JAK Inhibitor

for Dermatitis Atopic

Drug: Amlitelimab

42 locations incl. Birmingham

Sponsor: Sanofi

Sex: All·Age: 12+

Code: NCT06241118·Phase 3·Recruiting

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Extension to a Pivotal Study of Sensory Stimulation in Alzheimer's Disease (OLE Hope Study, CA-0015)

for Alzheimer Disease

53 locations incl. Phoenix

Sponsor: Cognito Therapeutics, Inc.

Sex: All·Age: 50 - 92

Code: NCT06245031·Enrolling By Invitation

Cost Communication and Financial Navigation in Cancer Patients (COSTCOM)

for Malignant Solid Neoplasm

384 locations incl. Anchorage

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06295367·Recruiting

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Phase IIIb Study of Ribociclib + ET in Early Breast Cancer

for Early Breast Cancer

Drug: Ribociclib

78 locations incl. Birmingham

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT05827081·Phase 3·Recruiting

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A Study of Raludotatug Deruxtecan (R-DXd) in Subjects With Platinum-resistant, High-grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

for Solid Cancer

43 locations incl. Anchorage

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06161025·Phase 2, Phase 3·Recruiting

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Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia

for AML

38 locations incl. Gilbert

Sponsor: Kura Oncology, Inc.

Sex: All·Age: 18+

Code: NCT06001788·Phase 1·Recruiting

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The Society for Obstetric Anesthesia and Perinatology Research Network General Anesthesia Registry

for Cesarean Delivery

34 locations incl. Little Rock

Sponsor: Yale University

Sex: Female·Age: 15 - 55·Accepts healthy volunteers

Code: NCT06030063·Recruiting

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Maturation of Arteriovenous Fistula With Automated Sonography Assessments Trial

for Diabetes

21 locations incl. Dothan

Sponsor: Sonavex, Inc.

Sex: All·Age: 18 - 84

Code: NCT06190717·Recruiting

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A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease

for COPD (Chronic Obstructive Pulmonary Disease)

234 locations incl. Athens

Sponsor: AstraZeneca

Sex: All·Age: 40 - 80

Code: NCT06283966·Phase 3·Recruiting

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