Paid Clinical Trials in South Carolina

South Carolina has 1,217 paid clinical trials enrolling now across cities including Charleston, Greenville and Columbia. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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1,101 clinical trials

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Using Biomarker Tests to Select and Test New, Personalized Treatments for Extensive Stage Small Cell Lung Cancer, PRISM Study

for Extensive Stage Lung Small Cell Carcinoma

Sites in Greenville, Greer +144 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06769126·Phase 2·Recruiting·Listed Jan 2025

Apply to this trial

Electronic Cigarettes as a Harm Reduction Strategy Among People With Opioid Use Disorder on Buprenorphine

for Tobacco-flavored EC

1 location in Greenville

Sponsor: Prisma Health-Upstate

Sex: All·Age: 21+

Code: NCT07202039·Recruiting·Listed Oct 2025

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Emotional Recovery Post-Stroke

for Stroke

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 21+

Code: NCT06782321·Recruiting·Listed Jan 2025

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Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection

for Shiga Toxin-Producing Escherichia Coli (E. Coli) Infection

Sites in Charleston +21 more locations

Sponsor: University of Calgary

Sex: All·Age: 9 Months - 21

Code: NCT05219110·Recruiting·Listed Feb 2022

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Evaluating the Communication Between Patients and Providers in Cancer Clinics

for Cancer

Sites in Charleston +2 more locations

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 18+

Code: NCT06985953·Recruiting·Listed May 2025

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Comparing Cooling and/or Compression Approaches of Limbs for Prevention of Chemotherapy-Induced Peripheral Neuropathy

for Malignant Solid Neoplasm

Sites in Spartanburg, Greer +31 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05642611·Phase 3·Recruiting·Listed Dec 2022

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Safety Study of Unlicensed IND Cord Blood Units Manufactured by the National Cord Blood Program for Unrelated Transplantation

for Infusion Reactions

Sites in Charleston +59 more locations

Sponsor: New York Blood Center

Sex: All·Age: All ages

Code: NCT01656603·Phase 2·Recruiting·Listed Aug 2012

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E-cigarette Cessation in Adults Who Co-use Cannabis

for Nicotine Dependence

Sites in Charleston, Lancaster & Pickens

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT06688539·Phase 4·Recruiting·Listed Nov 2024

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Examining Whether Project Support Works

for Parent-Child Relations

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 6 - 13

Code: NCT06963554·Recruiting·Listed May 2025

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The SNAP Tool for Head and Neck Cancer Survivor-Caregiver Dyads

for Head and Neck Cancer

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT05811936·Recruiting·Listed Apr 2023

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NEPTUNE Match Study

for Nephrotic Syndrome in Children

Sites in Charlotte +15 more locations

Sponsor: University of Michigan

Sex: All·Age: 1 - 80

Code: NCT04571658·Recruiting·Listed Oct 2020

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ERP to Improve Functioning in Veterans With OCD

for Obsessive Compulsive Disorder (OCD)

Sites in Charleston +18 more locations

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05240924·Recruiting·Listed Feb 2022

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Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer

for Anatomic Stage I Breast Cancer AJCC v8

Sites in Greenville, Greer +913 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05929768·Phase 3·Recruiting·Listed Jul 2023

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Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors

for Metastatic Malignant Neoplasm in the Liver

Sites in Charleston, Greenville +378 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05040360·Phase 2·Recruiting·Listed Sep 2021

Apply to this trial

Education & Mentorship of Advanced Practice Providers to Increase Community-based Research Within the NCORP Network, COACH-APP Trial

for Other

Sites in Greenville, Spartanburg +29 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06904391·Recruiting·Listed Apr 2025

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RaDIANT Health Systems Intervention

for End Stage Renal Disease (ESRD)

Sites in Lancaster +4 more locations

Sponsor: Indiana University

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07033117·Recruiting·Listed Jun 2025

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GLP1 Fasting Status and Gastric Retention Using Gastric Ultrasound

for Gastric Retention

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07251803·Recruiting·Listed Nov 2025

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tFUS Induced Transient Scotoma for Individual Dosing

for Healthy

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT06426498·Recruiting·Listed May 2024

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Cognitive Decline Following Deep Brain Stimulation

for Parkinson Disease

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05822388·Recruiting·Listed Apr 2023

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Train Your Brain Fitness SC: An Exercise Intervention for People With Cognitive Impairments

for Mild-moderate Cognitive Impairment

Sites in Columbia & Sumter

Sponsor: University of South Carolina

Sex: All·Age: 18+

Code: NCT06799429·Recruiting·Listed Jan 2025

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Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

for Metastatic Lung Small Cell Carcinoma

Sites in Florence +147 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT04804644·Phase 3·Recruiting·Listed Mar 2021

Apply to this trial

IMPACT (IMproving Proactive Approaches for Cancer Survivors' Mental Health Treatment)

for Depression

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06582784·Recruiting·Listed Sep 2024

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Accelerated iTBS for Post Partum Depression

for Post Partum Depression

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: Female·Age: 18 - 50

Code: NCT03417960·Recruiting·Listed Jan 2018

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PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes

for Type2Diabetes

Sites in Charleston, Orangeburg +34 more locations

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 40 - 80

Code: NCT05390892·Phase 4·Recruiting·Listed May 2022

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Tele-PCIT for Healthy Relationships in Families At-Risk

for Disruptive Behavior

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 2 - 7

Code: NCT07225010·Recruiting·Listed Nov 2025

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Evaluating NALIRIFOX vs Modified Gemcitabine, Nab-Paclitaxel and Cisplatin in Patients With Locally Advanced and Metastatic Pancreatic Adenocarcinoma

for Metastatic Pancreatic Adenocarcinoma

2 locations in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07076212·Phase 2·Recruiting·Listed Jul 2025

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Single Versus Dual Implant Fixation of Distal Femur Fractures

for Articular Fractures

Sites in Greenville +15 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06286670·Recruiting·Listed Feb 2024

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Weekly Isotretinoin vs Tetracycline for Moderate Acne

for Acne Vulgaris

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 12+·Accepts healthy volunteers

Code: NCT06225570·EARLY_Phase 1·Recruiting·Listed Jan 2024

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Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

for Breast Cancer

Sites in Charleston +14 more locations

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04468061·Phase 2·Recruiting·Listed Jul 2020

Apply to this trial

LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia

for Advanced Colorectal Carcinoma

Sites in Greenville, Spartanburg +194 more locations

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT06073431·Recruiting·Listed Oct 2023

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Longitudinal Screening for Financial Hardship to Improve Outcomes in Patients With Advanced Cancer

for Advanced Cancer

Sites in Spartanburg +5 more locations

Sponsor: Alliance Foundation Trials, LLC.

Sex: All·Age: 21+

Code: NCT06963723·Recruiting·Listed May 2025

Apply to this trial

Weight Loss and ExeRcise for Post-stroke Veterans

for Stroke

1 location in Charleston

Sponsor: VA Office of Research and Development

Sex: All·Age: 40 - 80

Code: NCT06322030·Recruiting·Listed Mar 2024

Apply to this trial

Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma

for Diffuse Large B-Cell Lymphoma

Sites in Charleston, Greenville +81 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05633615·Phase 2·Recruiting·Listed Dec 2022

Apply to this trial

COAST Therapy in Advanced Solid Tumors and Prostate Cancer

for Prostate Cancer Recurrent

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT05036226·Phase 1, Phase 2·Recruiting·Listed Sep 2021

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Heated Intraperitoneal Chemotherapy Followed by Niraparib for Ovarian, Primary Peritoneal and Fallopian Tube Cancer

for Stage III Ovarian Cancer

Drug: Niraparib

Sites in Charleston +58 more locations

Sponsor: GOG Foundation

Sex: Female·Age: 18+

Code: NCT05659381·Phase 3·Recruiting·Listed Dec 2022

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Platform of Randomized Adaptive Clinical Trials in Critical Illness

for Respiratory Insufficiency

Sites in Charleston +25 more locations

Sponsor: University Health Network, Toronto

Sex: All·Age: 18+

Code: NCT05440851·Recruiting·Listed Jul 2022

Apply to this trial

Risk Adapted De-Intensification of Radio-Chemotherapy for Oropharyngeal Squamous Cell Carcinoma

for Oropharyngeal Squamous Cell Carcinoma

Sites in Charleston +2 more locations

Sponsor: University of Florida

Sex: All·Age: 18+

Code: NCT05268614·Phase 2·Recruiting·Listed Mar 2022

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Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer

for Colorectal Cancer

Sites in Greenville, Spartanburg +140 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 60+

Code: NCT03998202·Recruiting·Listed Jun 2019

Apply to this trial

Methadone in THA for Post-op Pain and Opioid Reduction

for Post Operative Pain

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 75

Code: NCT07227064·Phase 3·Recruiting·Listed Nov 2025

Apply to this trial

Brain Metastases in Greater Size - Hypofractionated Options Trial (BIGSHOT)

for Brain Metastases

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07227610·Phase 2·Recruiting·Listed Nov 2025

Apply to this trial