Paid Clinical Trials in South Dakota

South Dakota has 310 paid clinical trials enrolling now across cities including Sioux Falls, Rapid City and Pierre. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 30, 2026.

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294 clinical trials

Nectero EAST System Clinical Study

for Abdominal Aortic Aneurysm

Sites in Sioux Falls +32 more locations

Sponsor: Nectero Medical, Inc.

Sex: All·Age: 21 - 85

Code: NCT06001918·Phase 2, Phase 3·Recruiting·Listed Aug 2023

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A Study of Azenosertib (ZN-c3) in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer

for High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer

Sites in Sioux Falls +33 more locations

Sponsor: K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc

Sex: Female·Age: 18+

Code: NCT05128825·Phase 2·Recruiting·Listed Nov 2021

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A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With Compensated Cirrhosis Due to MASH

for Metabolic Dysfunction-Associated Steatohepatitis (MASH) / Nonalcoholic Steatohepatitis (NASH) With Compensated Cirrhosis

Sites in Rapid City +132 more locations

Sponsor: 89bio, Inc.

Sex: All·Age: 18 - 75

Code: NCT06419374·Phase 3·Recruiting·Listed May 2024

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Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease

for Moderately to Severely Active Crohn Disease

Sites in Rapid City +42 more locations

Sponsor: Abivax S.A.

Sex: All·Age: 18 - 75

Code: NCT06456593·Phase 2·Recruiting·Listed Jun 2024

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The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

for Functional Mitral Regurgitation

Sites in Sioux Falls +50 more locations

Sponsor: Cardiac Dimensions, Inc.

Sex: All·Age: 18+

Code: NCT03142152·Recruiting·Listed May 2017

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Proact: A Study of REACT in Subjects With Type 2 Diabetes Mellitus and Chronic Kidney Disease

for Type 2 Diabetes Mellitus

Sites in Dakota Dunes +57 more locations

Sponsor: Prokidney

Sex: All·Age: 30 - 80

Code: NCT05099770·Phase 3·Recruiting·Listed Oct 2021

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EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)

for Breast Cancer

Sites in Sioux Falls +52 more locations

Sponsor: Exact Sciences Corporation

Sex: All·Age: 18+

Code: NCT06401421·Recruiting·Listed May 2024

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A Study to Evaluate Vimseltinib in Adults With Active Chronic Graft-Versus-Host Disease (cGVHD)

for Chronic Graft-Versus-Host Disease (cGVHD)

Sites in Sioux Falls +25 more locations

Sponsor: Deciphera Pharmaceuticals, LLC

Sex: All·Age: 18+

Code: NCT06619561·Phase 2·Recruiting·Listed Oct 2024

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Prevalence of Antibodies and Cytokines in Participants With Chronic Granulomatous Disease

for Chronic Granulomatous Disease (CGD)

Sites in Pierre +49 more locations

Sponsor: Ensoma

Sex: All·Age: All ages

Code: NCT06605378·Recruiting·Listed Sep 2024

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Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening

for Lung Cancer Diagnosis

Sites in Pierre +35 more locations

Sponsor: Freenome Holdings Inc.

Sex: All·Age: 50+

Code: NCT06122077·Recruiting·Listed Nov 2023

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An Efficacy and Safety Study of Cenegermin Ophthalmic Solution Compared With Vehicle in the Treatment of PCED

for Persistent Corneal Epithelial Defect

Sites in Sioux Falls +17 more locations

Sponsor: Dompé Farmaceutici S.p.A

Sex: All·Age: 18+

Code: NCT07519902·Phase 3·Recruiting·Listed Apr 2026

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A Study to Assess Real-World Use and Outcomes of TAR-200 for Participants With Non-Muscle Invasive Bladder Cancer (NMIBC) in the United States

for Non-Muscle Invasive Bladder Neoplasms

Sites in Sioux Falls +12 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07309445·Recruiting·Listed Dec 2025

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A Clinical Study of Gocatamig (MK-6070) and Infinatamab Deruxtecan (MK-2400) in People With Small Cell Lung Cancer (MK-6070-003)

for Small Cell Lung Cancer Extensive Stage

Drug: Gocatamig

Sites in Sioux Falls +12 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT07227597·Phase 1, Phase 2·Recruiting·Listed Nov 2025

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A Study of Brenipatide in Adults Who Quit Smoking Cigarettes and Want to Avoid Relapse

for Smoking

Drug: Brenipatide

Sites in Sioux Falls +14 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT07223840·Phase 2·Recruiting·Listed Nov 2025

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A Study to Compare the Efficacy and Safety of BMS-986489 (BMS-986012+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).

for Extensive-Stage Small Cell Lung Cancer

Drug: Atezolizumab

Sites in Sioux Falls +17 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT06646276·Phase 3·Recruiting·Listed Oct 2024

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A Real-world Chronic Myelogenous Leukemia (CML) Patient Disease Registry to Describe Patient Experience and Clinical Outcomes Among Patients With CML Receiving Approved First or Second Line Tyrosine Kinase Inhibitor (TKI) Therapy

for Chronic Myelogenous Leukemia - Chronic Phase

Sites in Sioux Falls +16 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT07091019·Recruiting·Listed Jul 2025

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Evaluation of a Non-Implanted Electrical Stimulation Device for Overactive Bladder (OAB)

for Overactive Bladder (OAB)

Sites in Sioux Falls +14 more locations

Sponsor: FemPulse Corporation

Sex: Female·Age: 21+

Code: NCT07195656·Recruiting·Listed Sep 2025

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A Study of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01)

for Malignant Neoplasm

Sites in Sioux Falls +16 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 1 Month - 17

Code: NCT06941272·Phase 1, Phase 2·Recruiting·Listed Apr 2025

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A Study of Cemiplimab Plus Chemotherapy Versus Cemiplimab Plus Chemotherapy Plus Other Cancer Treatments for Adult Patients With Operable Non-Small Cell Lung Cancer (NSCLC)

for Non-Small Cell Lung Cancer

Drug: Cemiplimab

Sites in Watertown +14 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06465329·Phase 2·Recruiting·Listed Jun 2024

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Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

for B-cell Acute Lymphoblastic Leukemia

Sites in Sioux Falls +16 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 6 Months - 25

Code: NCT06395103·Phase 1, Phase 2·Recruiting·Listed May 2024

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Real-World Data Collection of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis When Used in Covered Endovascular Reconstruction of the Aortic Bifurcation (CERAB) to Treat Aortoiliac Occlusive Disease

for Aortoiliac Occlusive Disease

Sites in Sioux Falls +19 more locations

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18 - 100

Code: NCT06872905·Recruiting·Listed Mar 2025

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Investigation of Ubamatamab Combination Therapy in Adult Participants With Platinum-Resistant Ovarian Cancer

for Ovarian Cancer

Sites in Sioux Falls +20 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: Female·Age: 18+

Code: NCT06787612·Phase 2·Recruiting·Listed Jan 2025

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A Study of Tarlatamab in Combination With AB248 in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-311)

for Extensive Stage Small Cell Lung Cancer

Drug: Tarlatamab

Sites in Sioux Falls +12 more locations

Sponsor: Amgen

Sex: All·Age: 18 - 90

Code: NCT07037758·Phase 1·Recruiting·Listed Jun 2025

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KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)

for Carcinoma, Non-Small-Cell Lung

Sites in Sioux Falls +5 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT04165070·Phase 1, Phase 2·Recruiting·Listed Nov 2019

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Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)

for Breast Cancer

Sites in Sioux Falls +21 more locations

Sponsor: Celcuity Inc

Sex: All·Age: 18+

Code: NCT06757634·Phase 3·Recruiting·Listed Jan 2025

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BOOM-IBD2 Pivotal Clinical Trial

for Ulcerative Colitis

Sites in Sioux Falls +17 more locations

Sponsor: Boomerang Medical

Sex: All·Age: 18 - 85

Code: NCT06571669·Recruiting·Listed Aug 2024

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Phase 2 Study of ADX-038 in Complement-Mediated Kidney Disease

for IgAN

Sites in Dakota Dunes +10 more locations

Sponsor: ADARx Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06989359·Phase 2·Recruiting·Listed May 2025

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KEYMAKER-U01 Umbrella Master Study: Studies of Investigational Agents With Either Pembrolizumab (MK-3475) Alone or With Pembrolizumab PLUS Chemotherapy in Participants With Non-small Cell Lung Cancer (NSCLC) (MK-3475-U01/KEYMAKER-U01)

for Carcinoma, Non-Small-Cell Lung

Sites in Sioux Falls +5 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT04165798·Recruiting·Listed Nov 2019

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Phase 2 Study Evaluating Rapcabtagene Autoleucel in Participants With Diffuse Cutaneous Systemic Sclerosis

for Scleroderma, Diffuse

Sites in Sioux Falls +13 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 70

Code: NCT06655896·Phase 2·Recruiting·Listed Oct 2024

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Evaluation of Enhanced Lithotripsy System (ELS) in the Treatment of Urinary Stones, A Pivotal Trial

for Kidney Calculi

Sites in Sioux City +15 more locations

Sponsor: Avvio Medical

Sex: All·Age: 21+

Code: NCT06942949·Recruiting·Listed Apr 2025

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Helix Research Network

for Genetic Predisposition to Disease

Sites in Sioux Falls +13 more locations

Sponsor: Helix, Inc

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06057181·Recruiting·Listed Sep 2023

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A Clinical Trial to Evaluate the Safety and Efficacy of COM701 in Relapsed Platinum Sensitive Ovarian Cancer

for Ovarian Cancer

Sites in Sioux Falls +12 more locations

Sponsor: Compugen Ltd

Sex: Female·Age: 18+

Code: NCT06888921·Phase 1, Phase 2·Recruiting·Listed Mar 2025

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Oral Ifetroban in Patients With Idiopathic Pulmonary Fibrosis (IPF)

for Idiopathic Pulmonary Fibrosis

Sites in Sioux Falls +18 more locations

Sponsor: Cumberland Pharmaceuticals

Sex: All·Age: 40+

Code: NCT05571059·Phase 2·Recruiting·Listed Oct 2022

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Sapanisertib and Serabelisib (PIKTOR) With Paclitaxel and a Substudy With an Insulin-Suppressing Diet in Patients With Advanced/Recurrent Endometrial Cancer

for Endometrial Cancer

Sites in Sioux Falls +17 more locations

Sponsor: Faeth Therapeutics

Sex: Female·Age: 18+

Code: NCT06463028·Phase 2·Recruiting·Listed Jun 2024

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Melodi Matrix™ in Breast Reconstruction

for Breast Reconstruction

Sites in Rapid City +9 more locations

Sponsor: Melodi Health, Inc.

Sex: Female·Age: 22+

Code: NCT06027996·Recruiting·Listed Sep 2023

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A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Endometrial Cancer.

for Endometrial Cancer

Drug: Lifileucel

Sites in Sioux Falls +11 more locations

Sponsor: Iovance Biotherapeutics, Inc.

Sex: Female·Age: 18 - 70

Code: NCT06481592·Phase 2·Recruiting·Listed Jul 2024

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A Study to Evaluate Efficacy and Safety of MELT-300 for Procedural Sedation in Subjects Undergoing Cataract Extraction With Lens Replacement (CELR)

for Cataract

Sites in Sioux Falls +11 more locations

Sponsor: Melt Pharmaceuticals

Sex: All·Age: 18 - 65

Code: NCT06383273·Phase 3·Recruiting·Listed Apr 2024

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Study of Denikitug (GS-1811) Given Alone or With Nivolumab or With Chemotherapy in Adults With Advanced Colorectal Cancer

for Advanced Microsatellite Stable Colorectal Cancer

Drug: Nivolumab

Sites in Sioux Falls +4 more locations

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT07527858·Phase 2·Recruiting·Listed Apr 2026

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NORM-HF Pivotal Study

for Heart Failure

Sites in Sioux Falls +2 more locations

Sponsor: Foundry Innovation & Research 1, Limited (FIRE1)

Sex: All·Age: 18+

Code: NCT07574593·Recruiting·Listed May 2026

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Trial of Xaluritamig in Adults With Metastatic Castration-resistant Prostate Cancer

for Metastatic Castration-resistant Prostate Cancer (mCRPC)

Sites in Sioux Falls +7 more locations

Sponsor: Amgen

Sex: Male·Age: 18+

Code: NCT07493512·Phase 1·Recruiting·Listed Mar 2026

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