Paid Clinical Trials in South Dakota

South Dakota has 311 paid clinical trials enrolling now across cities including Sioux Falls, Rapid City and Pierre. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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296 clinical trials

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Nectero EAST System Clinical Study

for Abdominal Aortic Aneurysm

Sites in Sioux Falls +32 more locations

Sponsor: Nectero Medical, Inc.

Sex: All·Age: 21 - 85

Code: NCT06001918·Phase 2, Phase 3·Recruiting·Listed Aug 2023

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Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration

for Neovascular Age-Related Macular Degeneration (nAMD)

Sites in Rapid City +53 more locations

Sponsor: 4D Molecular Therapeutics

Sex: All·Age: 50+

Code: NCT07064759·Phase 3·Recruiting·Listed Jul 2025

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Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease

for Moderately to Severely Active Crohn Disease

Sites in Rapid City +42 more locations

Sponsor: Abivax S.A.

Sex: All·Age: 18 - 75

Code: NCT06456593·Phase 2·Recruiting·Listed Jun 2024

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The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

for Functional Mitral Regurgitation

Sites in Sioux Falls +50 more locations

Sponsor: Cardiac Dimensions, Inc.

Sex: All·Age: 18+

Code: NCT03142152·Recruiting·Listed May 2017

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A Study of Upadacitinib in Adult Participants With Moderate-to-Severe Atopic Dermatitis and Inadequate Response to Dupilumab

for Atopic Dermatitis

Drug: Upadacitinib

Sites in Rapid City +65 more locations

Sponsor: AbbVie

Sex: All·Age: 18 - 63

Code: NCT06389136·Phase 3·Recruiting·Listed Apr 2024

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EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)

for Breast Cancer

Sites in Sioux Falls +52 more locations

Sponsor: Exact Sciences Corporation

Sex: All·Age: 18+

Code: NCT06401421·Recruiting·Listed May 2024

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A Study to Evaluate Vimseltinib in Adults With Active Chronic Graft-Versus-Host Disease (cGVHD)

for Chronic Graft-Versus-Host Disease (cGVHD)

Sites in Sioux Falls +25 more locations

Sponsor: Deciphera Pharmaceuticals, LLC

Sex: All·Age: 18+

Code: NCT06619561·Phase 2·Recruiting·Listed Oct 2024

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Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening

for Lung Cancer Diagnosis

Sites in Pierre +35 more locations

Sponsor: Freenome Holdings Inc.

Sex: All·Age: 50+

Code: NCT06122077·Recruiting·Listed Nov 2023

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Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma

for Pancreatic Cancer

Drug: Atebimetinib

Sites in Sioux Falls +38 more locations

Sponsor: Immuneering Corporation

Sex: All·Age: 18+

Code: NCT07562152·Phase 3·Recruiting·Listed May 2026

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PRESERVE: LUPKYNIS in Combination With Belimumab, Obinutuzumab or Anifrolumab in Patients With Lupus Nephritis

for Lupus Nephritis

Sites in Dakota Dunes +26 more locations

Sponsor: Aurinia Pharmaceuticals Inc.

Sex: All·Age: 18 - 75

Code: NCT07611214·Phase 4·Recruiting·Listed May 2026

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An Efficacy and Safety Study of Cenegermin Ophthalmic Solution Compared With Vehicle in the Treatment of PCED

for Persistent Corneal Epithelial Defect

Sites in Sioux Falls +17 more locations

Sponsor: Dompé Farmaceutici S.p.A

Sex: All·Age: 18+

Code: NCT07519902·Phase 3·Recruiting·Listed Apr 2026

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A Study to Assess Real-World Use and Outcomes of TAR-200 for Participants With Non-Muscle Invasive Bladder Cancer (NMIBC) in the United States

for Non-Muscle Invasive Bladder Neoplasms

Sites in Sioux Falls +16 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07309445·Recruiting·Listed Dec 2025

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A Clinical Study of Gocatamig (MK-6070) and Infinatamab Deruxtecan (MK-2400) in People With Small Cell Lung Cancer (MK-6070-003)

for Small Cell Lung Cancer Extensive Stage

Drug: Gocatamig

Sites in Sioux Falls +12 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT07227597·Phase 1, Phase 2·Recruiting·Listed Nov 2025

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A Study of Brenipatide in Adults Who Quit Smoking Cigarettes and Want to Avoid Relapse

for Smoking

Drug: Brenipatide

Sites in Sioux Falls +16 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT07223840·Phase 2·Recruiting·Listed Nov 2025

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A Study to Compare the Efficacy and Safety of BMS-986489 (Atigotatug+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).

for Extensive-Stage Small Cell Lung Cancer

Drug: Atezolizumab

Sites in Sioux Falls +17 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT06646276·Phase 3·Recruiting·Listed Oct 2024

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Evaluating Minimal Residual Disease (MRD) Through Longitudinal Circulating Tumor DNA (ctDNA) Profiling in Breast Malignancies

for Breast Cancer

Sites in Sioux Falls +15 more locations

Sponsor: Tempus AI

Sex: All·Age: 18 - 99

Code: NCT07211178·Recruiting·Listed Oct 2025

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Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

for B-cell Acute Lymphoblastic Leukemia

Sites in Sioux Falls +16 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 6 Months - 25

Code: NCT06395103·Phase 1, Phase 2·Recruiting·Listed May 2024

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A Study of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01)

for Malignant Neoplasm

Sites in Sioux Falls +15 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 1 Month - 17

Code: NCT06941272·Phase 1, Phase 2·Recruiting·Listed Apr 2025

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Investigation of Ubamatamab Combination Therapy in Adult Participants With Platinum-Resistant Ovarian Cancer

for Ovarian Cancer

Sites in Sioux Falls +20 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: Female·Age: 18+

Code: NCT06787612·Phase 2·Recruiting·Listed Jan 2025

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A Real-world Chronic Myelogenous Leukemia (CML) Patient Disease Registry to Describe Patient Experience and Clinical Outcomes Among Patients With CML Receiving Approved First or Second Line Tyrosine Kinase Inhibitor (TKI) Therapy

for Chronic Myelogenous Leukemia - Chronic Phase

Sites in Sioux Falls +16 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT07091019·Recruiting·Listed Jul 2025

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Oral Ifetroban in Patients With Idiopathic Pulmonary Fibrosis (IPF)

for Idiopathic Pulmonary Fibrosis

Sites in Sioux Falls +17 more locations

Sponsor: Cumberland Pharmaceuticals

Sex: All·Age: 40+

Code: NCT05571059·Phase 2·Recruiting·Listed Oct 2022

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KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)

for Carcinoma, Non-Small-Cell Lung

Sites in Sioux Falls +5 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT04165070·Phase 1, Phase 2·Recruiting·Listed Nov 2019

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KEYMAKER-U01 Umbrella Master Study: Studies of Investigational Agents With Either Pembrolizumab (MK-3475) Alone or With Pembrolizumab PLUS Chemotherapy in Participants With Non-small Cell Lung Cancer (NSCLC) (MK-3475-U01/KEYMAKER-U01)

for Carcinoma, Non-Small-Cell Lung

Sites in Sioux Falls +5 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT04165798·Recruiting·Listed Nov 2019

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BOOM-IBD2 Pivotal Clinical Trial

for Ulcerative Colitis

Sites in Sioux Falls +16 more locations

Sponsor: Boomerang Medical

Sex: All·Age: 18 - 85

Code: NCT06571669·Recruiting·Listed Aug 2024

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Phase 2 Study of ADX-038 in Complement-Mediated Kidney Disease

for IgAN

Sites in Dakota Dunes +7 more locations

Sponsor: ADARx Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06989359·Phase 2·Recruiting·Listed May 2025

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Real-World Data Collection of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis When Used in Covered Endovascular Reconstruction of the Aortic Bifurcation (CERAB) to Treat Aortoiliac Occlusive Disease

for Aortoiliac Occlusive Disease

Sites in Sioux Falls +19 more locations

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18 - 100

Code: NCT06872905·Recruiting·Listed Mar 2025

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Evaluation of a Non-Implanted Electrical Stimulation Device for Overactive Bladder (OAB)

for Overactive Bladder (OAB)

Sites in Sioux Falls +14 more locations

Sponsor: FemPulse Corporation

Sex: Female·Age: 21+

Code: NCT07195656·Recruiting·Listed Sep 2025

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Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)

for Breast Cancer

Sites in Sioux Falls +21 more locations

Sponsor: Celcuity Inc

Sex: All·Age: 18+

Code: NCT06757634·Phase 3·Recruiting·Listed Jan 2025

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A Study of Tarlatamab in Combination With AB248 in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-311)

for Extensive Stage Small Cell Lung Cancer

Drug: Tarlatamab

Sites in Sioux Falls +12 more locations

Sponsor: Amgen

Sex: All·Age: 18 - 90

Code: NCT07037758·Phase 1·Recruiting·Listed Jun 2025

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Sapanisertib and Serabelisib (PIKTOR) With Paclitaxel and a Substudy With an Insulin-Suppressing Diet in Patients With Advanced/Recurrent Endometrial Cancer

for Endometrial Cancer

Sites in Sioux Falls +17 more locations

Sponsor: Faeth Therapeutics

Sex: Female·Age: 18+

Code: NCT06463028·Phase 2·Recruiting·Listed Jun 2024

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Helix Research Network

for Genetic Predisposition to Disease

Sites in Sioux Falls +13 more locations

Sponsor: Helix, Inc

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06057181·Recruiting·Listed Sep 2023

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A Clinical Trial to Evaluate the Safety and Efficacy of COM701 in Relapsed Platinum Sensitive Ovarian Cancer

for Ovarian Cancer

Sites in Sioux Falls +12 more locations

Sponsor: Compugen Ltd

Sex: Female·Age: 18+

Code: NCT06888921·Phase 1, Phase 2·Recruiting·Listed Mar 2025

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Melodi Matrix™ in Breast Reconstruction

for Breast Reconstruction

Sites in Rapid City +9 more locations

Sponsor: Melodi Health, Inc.

Sex: Female·Age: 22+

Code: NCT06027996·Recruiting·Listed Sep 2023

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A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Endometrial Cancer.

for Endometrial Cancer

Drug: Lifileucel

Sites in Sioux Falls +11 more locations

Sponsor: Iovance Biotherapeutics, Inc.

Sex: Female·Age: 18 - 70

Code: NCT06481592·Phase 2·Recruiting·Listed Jul 2024

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Evaluation of Enhanced Lithotripsy System (ELS) in the Treatment of Urinary Stones, A Pivotal Trial

for Kidney Calculi

Sites in Sioux City +15 more locations

Sponsor: Avvio Medical

Sex: All·Age: 21+

Code: NCT06942949·Recruiting·Listed Apr 2025

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A Study of Ifinatamab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01D/LIGHTBEAM-U01)

for Malignant Neoplasm

Sites in Sioux Falls +11 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 1 Month - 17

Code: NCT07630974·Phase 1, Phase 2·Recruiting·Listed Jun 2026

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NORM-HF Pivotal Study

for Heart Failure

Sites in Sioux Falls +8 more locations

Sponsor: Foundry Innovation & Research 1, Limited (FIRE1)

Sex: All·Age: 18+

Code: NCT07574593·Recruiting·Listed May 2026

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Study of Denikitug (GS-1811) Given Alone or With Nivolumab or With Chemotherapy in Adults With Advanced Colorectal Cancer

for Advanced Microsatellite Stable Colorectal Cancer

Drug: Nivolumab

Sites in Sioux Falls +4 more locations

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT07527858·Phase 2·Recruiting·Listed Apr 2026

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A Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) in High-Risk Stage I Non-Small Cell Lung Cancer (V940-014)

for Non-small Cell Lung Cancer

Sites in Sioux Falls +11 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT07513376·Phase 3·Recruiting·Listed Apr 2026

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Trial of Xaluritamig in Adults With Metastatic Castration-resistant Prostate Cancer

for Metastatic Castration-resistant Prostate Cancer (mCRPC)

Sites in Sioux Falls +8 more locations

Sponsor: Amgen

Sex: Male·Age: 18+

Code: NCT07493512·Phase 1·Recruiting·Listed Mar 2026

Apply to this trial