Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma

Conditions

• PDAC
• PDAC - Pancreatic Ductal Adenocarcinoma
• Pancreatic Adenocarcinoma
• Pancreatic Adenocarcinoma Metastatic
• Pancreatic Cancer
• Pancreatic Cancer Metastatic
• Pancreatic Ductal Adenocarcinoma
• Pancreatic Ductal Adenocarcinoma (PDAC)

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Atebimetinib — DRUG
  Once daily oral tablets
• GnP — DRUG
  Standard of care regimen for intravenous infusions of gemcitabine and nab-paclitaxel weekly for three weeks followed by one week without an infusion
• mGnP — DRUG
  Biweekly intravenous infusions of chemotherapy (gemcitabine and nab-paclitaxel)

Study Details

The purpose of this study is to evaluate the safety and efficacy of atebimetinib in combination with modified GnP compared with SOC GnP alone.

Key Dates

First listed

May 1, 2026

Start date

Jun 5, 2026

Status verified

Aug 2026

Primary completion

Jun 30, 2028

Completion

Feb 28, 2029

Study Design

Enrollment

510 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Atebimetinib + mGnP
  Atebimetinib in combination with modified gemcitabine and nab-paclitaxel for first line pancreatic adenocarcinoma
• Active Comparator: GnP
  Standard of care gemcitabine and nab-paclitaxel for first line pancreatic adenocarcinoma

Primary Outcome Measure

Overall Survival [ Time Frame: Up to approximately 2 years ]

Central Contacts

• Immuneering Study Team
  860-321-1302
  [email protected]

Locations (37)

Find similar trials in Huntsville, AL

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