Paid Clinical Trials in Sioux Falls, SD

As of July 2026, 242 paid clinical trials are recruiting in Sioux Falls, South Dakota. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 31, 2026.

Filter results

Filter results

State

City

Facility

Recruitment status

Phase

Study type

Intervention

Condition

Sex

Age

Healthy volunteers only

235 clinical trials

Sapanisertib and Serabelisib (PIKTOR) With Paclitaxel and a Substudy With an Insulin-Suppressing Diet in Patients With Advanced/Recurrent Endometrial Cancer

for Endometrial Cancer

Sites in Sioux Falls +17 more locations

Sponsor: Faeth Therapeutics

Sex: Female·Age: 18+

Code: NCT06463028·Phase 2·Recruiting·Listed Jun 2024

Apply to this trial

Oral Ifetroban in Patients With Idiopathic Pulmonary Fibrosis (IPF)

for Idiopathic Pulmonary Fibrosis

Sites in Sioux Falls +18 more locations

Sponsor: Cumberland Pharmaceuticals

Sex: All·Age: 40+

Code: NCT05571059·Phase 2·Recruiting·Listed Oct 2022

Apply to this trial

A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Endometrial Cancer.

for Endometrial Cancer

Drug: Lifileucel

Sites in Sioux Falls +11 more locations

Sponsor: Iovance Biotherapeutics, Inc.

Sex: Female·Age: 18 - 70

Code: NCT06481592·Phase 2·Recruiting·Listed Jul 2024

Apply to this trial

A Study to Evaluate Efficacy and Safety of MELT-300 for Procedural Sedation in Subjects Undergoing Cataract Extraction With Lens Replacement (CELR)

for Cataract

Sites in Sioux Falls +11 more locations

Sponsor: Melt Pharmaceuticals

Sex: All·Age: 18 - 65

Code: NCT06383273·Phase 3·Recruiting·Listed Apr 2024

Apply to this trial

Study of Denikitug (GS-1811) Given Alone or With Nivolumab or With Chemotherapy in Adults With Advanced Colorectal Cancer

for Advanced Microsatellite Stable Colorectal Cancer

Drug: Nivolumab

Sites in Sioux Falls +4 more locations

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT07527858·Phase 2·Recruiting·Listed Apr 2026

Apply to this trial

NORM-HF Pivotal Study

for Heart Failure

Sites in Sioux Falls +2 more locations

Sponsor: Foundry Innovation & Research 1, Limited (FIRE1)

Sex: All·Age: 18+

Code: NCT07574593·Recruiting·Listed May 2026

Apply to this trial

Trial of Xaluritamig in Adults With Metastatic Castration-resistant Prostate Cancer

for Metastatic Castration-resistant Prostate Cancer (mCRPC)

Sites in Sioux Falls +7 more locations

Sponsor: Amgen

Sex: Male·Age: 18+

Code: NCT07493512·Phase 1·Recruiting·Listed Mar 2026

Apply to this trial

Post Approval Effectiveness and Durability Evaluation of the Altaviva™ Tibial Device

for Urge Urinary Incontinence

Sites in Sioux Falls +9 more locations

Sponsor: MedtronicNeuro

Sex: All·Age: 18+

Code: NCT07456865·Recruiting·Listed Mar 2026

Apply to this trial

xDot Access Management System Early Feasibility Study

for Vascular Closure Devices

Sites in Sioux Falls +2 more locations

Sponsor: xDot Medical, Inc

Sex: All·Age: 18 - 80

Code: NCT07464353·Recruiting·Listed Mar 2026

Apply to this trial

A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer

for Breast Cancer

Drug: Ribociclib

Sites in Sioux Falls, Yankton +4 more locations

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT07405801·Phase 2·Recruiting·Listed Feb 2026

Apply to this trial

Ambulatory Long Length URodynamics Evaluation

for Urology

Sites in Sioux Falls +6 more locations

Sponsor: Bright Uro

Sex: All·Age: 22+

Code: NCT07425015·Recruiting·Listed Feb 2026

Apply to this trial

KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)

for Malignant Neoplasm

Sites in Sioux Falls +2 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT07252739·Phase 2·Recruiting·Listed Nov 2025

Apply to this trial

A Phase 1/2a, First-in-human, Study of BMS-986517 in Participants With Advanced Solid Tumors

for Solid Tumours

Drug: BMS-986517

Sites in Sioux Falls +8 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07160725·Phase 1, Phase 2·Recruiting·Listed Sep 2025

Apply to this trial

A Longitudinal Multi-Center Molecular Biomarker Discovery Registry for Patients With Hematologic Malignancies

for Acute Myeloid Leukaemia (AML)

Sites in Sioux Falls +8 more locations

Sponsor: Tempus AI

Sex: All·Age: 0+

Code: NCT07154823·Recruiting·Listed Sep 2025

Apply to this trial

Study of Trastuzumab Deruxtecan Versus Standard of Care Chemotherapy for HER2-Expressing (IHC 3+/2+) Endometrial Cancer

for Endometrial Cancer

Sites in Sioux Falls +9 more locations

Sponsor: Daiichi Sankyo

Sex: Female·Age: 18+

Code: NCT07022483·Phase 3·Recruiting·Listed Jun 2025

Apply to this trial

A Study of BGB-B455 in Adults With Advanced or Metastatic Solid Tumors

for Advanced Solid Tumor

Sites in Sioux Falls +4 more locations

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT06803680·Phase 1·Recruiting·Listed Jan 2025

Apply to this trial

Phase 3 Trial Evaluating the Safety & Efficacy of IMNN-001 Administered in Combination w/ Standard NACT & Adjuvant Chemotherapy in Newly Diagnosed Patients w/ Advanced EOC, Fallopian Tube or Primary Peritoneal Cancer

for Epithelial Ovarian Cancer

Sites in Sioux Falls +7 more locations

Sponsor: Imunon

Sex: Female·Age: 18+

Code: NCT06915025·Phase 3·Recruiting·Listed Apr 2025

Apply to this trial

Subcutaneous Tarlatamab in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-308)

for Extensive Stage Small Cell Lung Cancer

Drug: Tarlatamab

Sites in Sioux Falls +5 more locations

Sponsor: Amgen

Sex: All·Age: 18+

Code: NCT06598306·Phase 1·Recruiting·Listed Sep 2024

Apply to this trial

A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer

for Endometrial Cancer

Sites in Sioux Falls +9 more locations

Sponsor: BioNTech SE

Sex: Female·Age: 18+

Code: NCT06340568·Phase 3·Recruiting·Listed Apr 2024

Apply to this trial

A Study of Pembrolizumab (MK-3475) in Pediatric Participants With an Advanced Solid Tumor or Lymphoma (MK-3475-051/KEYNOTE-051)

for Melanoma

Sites in Sioux Falls +6 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 6 Months - 17

Code: NCT02332668·Phase 1, Phase 2·Recruiting·Listed Jan 2015

Apply to this trial

VIrtual STudy in Achondroplasia for the US (VISTA)

for Achondroplasia

Sites in Sioux Falls +7 more locations

Sponsor: BioMarin Pharmaceutical

Sex: All·Age: 0 Months - 18

Code: NCT06168201·Recruiting·Listed Dec 2023

Apply to this trial

A Study of Pembrolizumab With or Without Chemotherapy in Combination With Additional Treatments for Advanced Non-Small Cell Lung Cancer (NSCLC) (MK-3475-01G/KEYMAKER U01)

for Non-small Cell Lung Cancer

Sites in Sioux Falls +4 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06731907·Phase 2·Recruiting·Listed Dec 2024

Apply to this trial

Perform Humeral System Study

for Osteoarthritis Shoulder

Sites in Sioux Falls +3 more locations

Sponsor: Stryker Trauma and Extremities

Sex: All·Age: 18+

Code: NCT05067543·Recruiting·Listed Oct 2021

Apply to this trial

A Study of ASP-1929 Photoimmunotherapy in Combination With Pembrolizumab in First-line Treatment of Locoregional Recurrent Squamous Cell Carcinoma of the Head and Neck With No Distant Metastases

for Recurrent Head and Neck Squamous Cell Carcinoma

Sites in Sioux Falls +6 more locations

Sponsor: Rakuten Medical, Inc.

Sex: All·Age: 18+

Code: NCT06699212·Phase 3·Recruiting·Listed Nov 2024

Apply to this trial

Evaluating Patient Reported Outcomes and Surgeon Satisfaction With Ziplyft™

for Blepharoplasty

Sites in Sioux Falls +4 more locations

Sponsor: Osheru Inc.

Sex: All·Age: 35+

Code: NCT07144761·Recruiting·Listed Aug 2025

Apply to this trial

Pounce™ Thrombectomy System Retrospective Registry

for Peripheral Arterial Disease

Sites in Sioux Falls +6 more locations

Sponsor: SurModics, Inc.

Sex: All·Age: 18+

Code: NCT05868161·Recruiting·Listed May 2023

Apply to this trial

Testing the Addition of Anti-Cancer Drug Sonrotoclax, to the Standard Treatment Zanubrutinib, for Previously Untreated CLL/SLL

for Chronic Lymphocytic Leukemia

Drug: Sonrotoclax

Sites in Sioux Falls, Yankton +150 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 65+

Code: NCT07321652·Phase 3·Recruiting·Listed Jan 2026

Apply to this trial

Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

for Ampulla of Vater Carcinoma

Sites in Sioux Falls +331 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07283939·Recruiting·Listed Dec 2025

Apply to this trial

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

for Lung Non-Small Cell Carcinoma

Sites in Sioux Falls +634 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04267848·Phase 3·Recruiting·Listed Feb 2020

Apply to this trial

Testing Different Dosing Schedules of the Anti-cancer Drug, Lutetium 177Lu PSMA RLT and Its Effect on Patients With Advanced Prostate Cancer, RECIPROCAL Trial

for Metastatic Castration-Resistant Prostate Carcinoma

Sites in Sioux Falls +61 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: Male·Age: 18+

Code: NCT07200830·Phase 3·Recruiting·Listed Oct 2025

Apply to this trial

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

for Breast Cancer

Sites in Sioux Falls, Yankton +1103 more locations

Sponsor: NRG Oncology

Sex: Female·Age: 18 - 60

Code: NCT05879926·Phase 3·Recruiting·Listed May 2023

Apply to this trial

Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease

for Stage III Colon Cancer

Sites in Sioux Falls, Yankton +920 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT05174169·Phase 2, Phase 3·Recruiting·Listed Dec 2021

Apply to this trial

Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

for Advanced Lung Non-Squamous Non-Small Cell Carcinoma

Drug: Bevacizumab

Sites in Sioux Falls +327 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04181060·Phase 3·Recruiting·Listed Nov 2019

Apply to this trial

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

for Head and Neck Squamous Cell Carcinoma

Sites in Sioux Falls +465 more locations

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT02734537·Phase 2·Recruiting·Listed Apr 2016

Apply to this trial

Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

for Anatomic Stage II Breast Cancer AJCC v8

Sites in Sioux Falls, Yankton +774 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT05812807·Phase 3·Recruiting·Listed Apr 2023

Apply to this trial

Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer

for Locally Advanced Cervical Adenocarcinoma

Sites in Sioux Falls +295 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT07061977·Phase 3·Recruiting·Listed Jul 2025

Apply to this trial

mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma

for Advanced Esophageal Adenocarcinoma

Drug: Nivolumab

Sites in Sioux Falls, Yankton +641 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT05677490·Phase 3·Recruiting·Listed Jan 2023

Apply to this trial

ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab

for Anatomic Stage I Breast Cancer AJCC v8

Sites in Sioux Falls, Rapid City +583 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06876714·Phase 3·Recruiting·Listed Mar 2025

Apply to this trial

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

for Acute Lymphoblastic Leukemia

Sites in Sioux Falls +630 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 40 - 75·Accepts healthy volunteers

Code: NCT05334069·Recruiting·Listed Apr 2022

Apply to this trial

Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial

for Extensive Stage Lung Small Cell Carcinoma

Drug: Atezolizumab

Sites in Sioux Falls, Yankton +271 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04402788·Phase 2, Phase 3·Recruiting·Listed May 2020

Apply to this trial