Evaluation of Mesopic Visual Acuity and Patient Satisfaction Following Ray-Tracing-Guided LASIK
for Astigmatism
1 location in Sioux Falls
Sponsor: Vance Thompson Vision
Sex: All·Age: 18 - 45
Code: NCT07790185·Phase 4·Recruiting·Listed Aug 27, 2026
Paid Clinical Trials in South Dakota
South Dakota has 311 paid clinical trials enrolling now across cities including Sioux Falls, Rapid City and Pierre. Search by condition, age, or phase to find compensated research studies accepting participants near you.
Research sites in South Dakota include National Cancer Institute (NCI), AstraZeneca and Merck Sharp & Dohme LLC, running studies across oncology, cardiology, neurology, and more. The most actively recruiting conditions are Breast Cancer, Heart Failure, Ovarian Cancer, Endometrial Cancer — browse the full list or use the filters to match your diagnosis. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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Newly added in South Dakota
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
BL-RX01-TFSTAB-1402
for Dry Eye
1 location in Sioux Falls
Sponsor: Vance Thompson Vision
Sex: All·Age: 18+·Accepts healthy volunteers
Code: NCT07790211·Phase 4·Recruiting·Listed Aug 27, 2026
A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF
for Heart Failure With Preserved Ejection Fraction (HFpEF)
Sites in Rapid City +106 more locations
Sponsor: AstraZeneca
Sex: All·Age: 18+
Code: NCT07761117·Phase 3·Recruiting·Listed Aug 12, 2026
A Study to Investigate Outcomes With Elecoglipron Compared With Placebo in Adult Participants With Chronic Kidney Disease.
for Chronic Kidney Disease
Sites in Rapid City +110 more locations
Sponsor: AstraZeneca
Sex: All·Age: 18+
Code: NCT07753993·Phase 3·Recruiting·Listed Aug 10, 2026
296 clinical trials
Get a weekly email when new trials open in Sioux Falls, SD.
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
for Obesity
Drug: NNC0487-0111
Sites in Rapid City +205 more locations
Sponsor: Novo Nordisk A/S
Sex: All·Age: 18+
Code: NCT07567001·Phase 3·Recruiting·Listed May 2026
A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma
for Solid Tumors
Drug: INCB161734
Sites in Sioux Falls +69 more locations
Sponsor: Incyte Corporation
Sex: All·Age: 18+
Code: NCT07522073·Phase 3·Recruiting·Listed Apr 2026
LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis
for Ulcerative Colitis (UC)
Drug: LY4268989
Sites in Sioux Falls +49 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18 - 80
Code: NCT07415044·Phase 2·Recruiting·Listed Feb 2026
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
for Depressive Disorder, Major
Drug: Brenipatide
Sites in Sioux Falls +31 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18 - 75
Code: NCT07412756·Phase 3·Recruiting·Listed Feb 2026
A Study of Brenipatide in Participants With Opioid Use Disorder
for Opioid Use Disorder
Drug: Brenipatide
Sites in Sioux Falls +37 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18 - 75
Code: NCT07420283·Phase 2·Recruiting·Listed Feb 2026
A Double-blind, Randomized Controlled Trial to Investigate the Efficacy, Safety, and Pharmacokinetics of Pegloticase Administration Via Subcutaneous and Intravenous Routes Both With Methotrexate in Participants With Uncontrolled Gout
for Uncontrolled Gout
Sites in Rapid City +69 more locations
Sponsor: Amgen
Sex: All·Age: 18+
Code: NCT07388498·Phase 3·Recruiting·Listed Feb 2026
A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate to Severe Chronic Obstructive Pulmonary Disease
for Moderate to Severe Chronic Obstructive Pulmonary Disease
Drug: PF-07275315
Sites in Rapid City +60 more locations
Sponsor: Pfizer
Sex: All·Age: 35 - 80
Code: NCT07363694·Phase 2, Phase 3·Recruiting·Listed Jan 2026
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes
for Obesity or Overweight
Drug: Enicepatide
Sites in Sioux Falls +40 more locations
Sponsor: Hoffmann-La Roche
Sex: All·Age: 18+
Code: NCT07351045·Phase 3·Recruiting·Listed Jan 2026
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight and Type 2 Diabetes
for Obesity or Overweight
Drug: Enicepatide
Sites in Sioux Falls +37 more locations
Sponsor: Hoffmann-La Roche
Sex: All·Age: 18+
Code: NCT07351058·Phase 3·Recruiting·Listed Jan 2026
Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
for Intestinal Neoplasms
Drug: PF-08634404
Sites in Sioux Falls, Pierre +198 more locations
Sponsor: Pfizer
Sex: All·Age: 18+
Code: NCT07222800·Phase 3·Recruiting·Listed Oct 2025
A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
for CRC (Colorectal Cancer)
Drug: Bevacizumab
Sites in Sioux Falls +70 more locations
Sponsor: Incyte Corporation
Sex: All·Age: 18+
Code: NCT07284849·Phase 3·Recruiting·Listed Dec 2025
Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)
for Pancreatic Cancer
Drug: daraxonrasib
Sites in Sioux Falls +34 more locations
Sponsor: Revolution Medicines, Inc.
Sex: All·Age: 18+
Code: NCT07252232·Phase 3·Recruiting·Listed Nov 2025
A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight
for Overweight
Sites in Rapid City +33 more locations
Sponsor: Novo Nordisk A/S
Sex: All·Age: 8 - 18
Code: NCT07253285·Phase 3·Recruiting·Listed Nov 2025
A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer
for Prostatic Neoplasms, Castration-Resistant
Drug: Pasritamig
Sites in Sioux Falls +52 more locations
Sponsor: Janssen Research & Development, LLC
Sex: All·Age: 18+
Code: NCT07225946·Phase 3·Recruiting·Listed Nov 2025
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
for Untreated, Unresectable, or Metastatic Colorectal Cancer
Drug: Bevacizumab
Sites in Sioux Falls +43 more locations
Sponsor: Bristol-Myers Squibb
Sex: All·Age: 18+
Code: NCT07221357·Phase 2, Phase 3·Recruiting·Listed Oct 2025
A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract
for Carcinoma, Transitional Cell
Sites in Sioux Falls +63 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18+
Code: NCT07218380·Phase 3·Recruiting·Listed Oct 2025
A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
for Breast Neoplasms
Sites in Sioux Falls +125 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18+
Code: NCT07174336·Phase 3·Recruiting·Listed Sep 2025
Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)
for Elevated Lp(a)
Drug: Muvalaplin
Sites in Sioux Falls +156 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18+
Code: NCT07157774·Phase 3·Recruiting·Listed Sep 2025
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
for Diabetes Mellitus, Type 2
Drug: Empagliflozin
Sites in Dakota Dunes +203 more locations
Sponsor: Boehringer Ingelheim
Sex: All·Age: 18+
Code: NCT07064473·Phase 3·Recruiting·Listed Jul 2025
A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder
for Alcohol Use Disorder
Drug: Brenipatide
Sites in Sioux Falls +29 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18 - 75
Code: NCT07219966·Phase 3·Recruiting·Listed Oct 2025
A Study of Brenipatide in Participants With Alcohol Use Disorder
for Alcohol Use Disorder
Drug: Brenipatide
Sites in Sioux Falls +28 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18 - 75
Code: NCT07219953·Phase 3·Recruiting·Listed Oct 2025
OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events
for Cardiovascular Disease
Drug: Olpasiran
Sites in Rapid City +193 more locations
Sponsor: Amgen
Sex: All·Age: 50 - 105
Code: NCT07136012·Phase 3·Recruiting·Listed Aug 2025
Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer
for Breast Neoplasms
Sites in Sioux Falls +48 more locations
Sponsor: Natera, Inc.
Sex: All·Age: 18+
Code: NCT07214532·Recruiting·Listed Oct 2025
Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
for Atherosclerotic Cardiovascular Disease
Sites in Rapid City +136 more locations
Sponsor: Amgen
Sex: All·Age: 45 - 99
Code: NCT07037433·Phase 3·Recruiting·Listed Jun 2025
A Study of Dotinurad Versus Allopurinol in Participants With Gout
for Gout
Drug: Dotinurad
Sites in Rapid City +75 more locations
Sponsor: Crystalys Therapeutics
Sex: All·Age: 18 - 75
Code: NCT07089875·Phase 3·Recruiting·Listed Jul 2025
A Study of Dotinurad Versus Allopurinol in Tophaceous Gout
for Tophaceous Gout
Drug: Dotinurad
Sites in Rapid City +81 more locations
Sponsor: Crystalys Therapeutics
Sex: All·Age: 18 - 75
Code: NCT07089888·Phase 3·Recruiting·Listed Jul 2025
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
for Triple Negative Breast Cancer
Sites in Sioux Falls, Rapid City +119 more locations
Sponsor: Gilead Sciences
Sex: All·Age: 18+
Code: NCT05633654·Phase 3·Recruiting·Listed Dec 2022
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
for Breast Cancer
Sites in Sioux Falls, Pierre +170 more locations
Sponsor: Stemline Therapeutics, Inc.
Sex: All·Age: 18+
Code: NCT06492616·Phase 3·Recruiting·Listed Jul 2024
Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
for Ovarian Cancer
Drug: INCB123667
Sites in Sioux Falls +47 more locations
Sponsor: Incyte Corporation
Sex: Female·Age: 18+
Code: NCT07214779·Phase 3·Recruiting·Listed Oct 2025
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
for Osteoarthritis
Drug: Orforglipron
Sites in Rapid City +25 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18+
Code: NCT07153471·Phase 3·Recruiting·Listed Sep 2025
A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy
for Age-related Macular Degeneration (AMD)
Drug: Cemdisiran
Sites in Rapid City +140 more locations
Sponsor: Regeneron Pharmaceuticals
Sex: All·Age: 50 - 85
Code: NCT06541704·Phase 3·Recruiting·Listed Aug 2024
A Phase 2, Randomized, Placebo Controlled, Multicenter, Masked Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamics of Multidose APL 3007 in Combination With Syfovre/Pegcetacoplan (APL-2) in Patients Diagnosed With Geographic Atrophy Secondary to Age Related Macular Degeneratio
for Geographic Atrophy Secondary to Age-related Macular Degeneration
Drug: Pegcetacoplan
Sites in Sioux Falls +77 more locations
Sponsor: Apellis Pharmaceuticals, Inc.
Sex: All·Age: 60+
Code: NCT07215390·Phase 2·Recruiting·Listed Oct 2025
Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)
for Triple-Negative Breast Cancer
Sites in Sioux Falls +82 more locations
Sponsor: Merck Sharp & Dohme LLC
Sex: All·Age: 18+
Code: NCT06393374·Phase 3·Recruiting·Listed May 2024
Long-Term Safety Study of Deucravacitinib Versus Ustekinumab in Participants With Psoriasis (PRAGMATYK)
for Plaque Psoriasis
Drug: Deucravacitinib
Sites in Rapid City +96 more locations
Sponsor: Bristol-Myers Squibb
Sex: All·Age: 40+
Code: NCT07116967·Phase 3·Recruiting·Listed Aug 2025
Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer
for Carcinoma, Non-Small-Cell Lung
Drug: LY3537982
Sites in Sioux Falls +90 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18+
Code: NCT06890598·Phase 3·Recruiting·Listed Mar 2025
A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)
for Breast Neoplasms
Sites in Sioux Falls, Yankton +61 more locations
Sponsor: Merck Sharp & Dohme LLC
Sex: All·Age: 18+
Code: NCT06966700·Phase 3·Recruiting·Listed May 2025
Phase IIIb Study of Ribociclib + ET in Early Breast Cancer
for Early Breast Cancer
Drug: Ribociclib
Sites in Sioux Falls +77 more locations
Sponsor: Novartis Pharmaceuticals
Sex: All·Age: 18 - 100
Code: NCT05827081·Phase 3·Recruiting·Listed Apr 2023
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
for Colorectal Neoplasms
Sites in Sioux Falls +107 more locations
Sponsor: Seagen, a wholly owned subsidiary of Pfizer
Sex: All·Age: 18+
Code: NCT05253651·Phase 3·Recruiting·Listed Feb 2022
A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
for Crohn's Disease
Drug: Tulisokibart
Sites in Sioux Falls +70 more locations
Sponsor: Merck Sharp & Dohme LLC
Sex: All·Age: 16 - 80
Code: NCT06430801·Phase 3·Recruiting·Listed May 2024
A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)
for Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer
Drug: Giredestrant
Sites in Sioux Falls +11 more locations
Sponsor: Hoffmann-La Roche
Sex: All·Age: 18+
Code: NCT06065748·Phase 3·Recruiting·Listed Oct 2023
Common conditions studied in South Dakota
- Breast Cancer (11 active studies)
- Heart Failure (11 active studies)
- Ovarian Cancer (9 active studies)
- Endometrial Cancer (8 active studies)
- Stage IV Lung Cancer AJCC v8 (7 active studies)
- Malignant Solid Neoplasm (5 active studies)
Leading research sponsors in South Dakota
- National Cancer Institute (NCI)
- AstraZeneca
- Merck Sharp & Dohme LLC
- Alliance for Clinical Trials in Oncology
- Children's Oncology Group
Frequently asked questions
How many paid clinical trials are currently recruiting in South Dakota?
There are approximately 311 recruiting clinical trials in South Dakota listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in South Dakota pay participants?
Most recruiting trials in South Dakota compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in South Dakota?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in South Dakota?
The most common conditions under active study in South Dakota include Breast Cancer (11), Heart Failure (11), Ovarian Cancer (9), Endometrial Cancer (8), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in South Dakota?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in South Dakota on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in South Dakota?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.