Paid Clinical Trials in Tennessee

Tennessee has 2,076 paid clinical trials enrolling now across cities including Nashville, Memphis and Knoxville. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Tennessee include Vanderbilt University Medical Center and St. Jude Children's Research Hospital, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 31, 2026.

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1,847 clinical trials

Vanderbilt Integrated Community TMS for Opioid Recovery

for Opiod Use Disorder

Sites in Nashville & Brentwood

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18 - 65

Code: NCT07457489·Recruiting·Listed Mar 2026

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A Study of Safety and Drug Levels of ePGT121v1-LS, PGDM1400LS, and VRC07-523LS in Adult Participants Without HIV-1

for HIV

Sites in Nashville +6 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07390955·Phase 1·Recruiting·Listed Feb 2026

Apply to this trial

A Longitudinal Photo-Narrative Exploration of Hope During Phase 1/2 Clinical Trials For Pediatric Cancer

for Cancer, Therapy-Related

1 location in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: 12+

Code: NCT07444216·Recruiting·Listed Mar 2026

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Neurophysiology of Reward Signaling in Parkinson's Disease

for Parkinson Disease

1 location in Nashville

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 40+

Code: NCT07409207·Recruiting·Listed Feb 2026

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Functional Ovarian Reserve in Sickle Cell Disease

for Sickle Cell Disease

1 location in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: Female·Age: 10 - 18·Accepts healthy volunteers

Code: NCT07392216·Recruiting·Listed Feb 2026

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Pharmacokinetic Analysis of Cefiderocol in Patients With Acute Burn Injuries

for Drug Clearance After Severe Burn Injury

1 location in Memphis

Sponsor: University of Tennessee

Sex: All·Age: 18 - 80

Code: NCT07465432·Phase 4·Recruiting·Listed Mar 2026

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Bowel Continence Across the Lifespan in People With Spina Bifida

for Spina Bifida

Sites in Nashville +23 more locations

Sponsor: David Chu

Sex: All·Age: 5+

Code: NCT07390318·Recruiting·Listed Feb 2026

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Exogenous Ketone Supplementation in ICU Delirium

for ICU Delirium

1 location in Nashville

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18+

Code: NCT07364162·Phase 2·Recruiting·Listed Jan 2026

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A Study of Targeted Post-Surgery Radiation Therapy for Non-Small Cell Lung Cancer With Remaining Lymph Node Cancer After Treatment

for Lung Non-Small Cell Carcinoma

Sites in Memphis, Collierville +31 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT07293247·Phase 2·Recruiting·Listed Dec 2025

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PREcision MEDicine In Achalasia (PREMEDIA)

for Type I Achalasia

Sites in Nashville +14 more locations

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07293650·Phase 3·Recruiting·Listed Dec 2025

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PREcision MEDicine In Achalasia (PREMEDIA) - Cohort

for Type III Achalasia

Sites in Nashville +14 more locations

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07293689·Recruiting·Listed Dec 2025

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Increasing Germline Genetic Testing for Patients With Cancer

for Hereditary Pancreatic Cancer

Sites in Nashville +9 more locations

Sponsor: Josh Peterson

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07307664·Recruiting·Listed Dec 2025

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Stakeholders of Rare Diseases Informing Values In Neuroethics

for Rare Disorder

1 location in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: All ages

Code: NCT07314736·Recruiting·Listed Jan 2026

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Evaluation of Scalp Cooling During Chemotherapy on Quality of Life and the Potential Role of Single Nucleotide Variations on Chemotherapy-Induced Alopecia and Hair Regrowth in the Appalachian Highlands Region

for Alopecia

1 location in Kingsport

Sponsor: Charles Mays

Sex: All·Age: 18+

Code: NCT07422376·Recruiting·Listed Feb 2026

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MAPT Protocol: Fixation Versus Arthroplasty Surgical Treatments for Early Recovery After HIP Fracture (FASTER-HIP)

for Femoral Neck Fractures

Sites in Nashville +17 more locations

Sponsor: University of Southern California

Sex: All·Age: 60+

Code: NCT07244211·Recruiting·Listed Nov 2025

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Deceased Donor Kidney Storage at 10 Celsius Versus Conventional Storage

for End Stage Chronic Renal Failure

1 location in Nashville

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18+

Code: NCT07385651·Recruiting·Listed Feb 2026

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Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

for Advanced Endometrial Carcinoma

Drug: Bevacizumab

Sites in Nashville, Franklin +235 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT07198074·Phase 3·Recruiting·Listed Sep 2025

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CD45RA-depleted CD19-CAR T Cell Consolidation After TCRαβ+/CD19 B Cell-depleted Haploidentical Hematopoietic Cell Transplantation for Relapsed/Refractory CD19+ ALL and Lymphoma

for Relapsed Pediatric ALL

1 location in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: Up to 21

Code: NCT07257419·Phase 1·Recruiting·Listed Dec 2025

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Beverage Hydration Index of Different Solutions

for Hydration

1 location in Memphis

Sponsor: University of Memphis

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07507344·Recruiting·Listed Apr 2026

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Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer

for Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

Sites in Nashville +100 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07195734·Phase 2·Recruiting·Listed Sep 2025

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Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

for Lung Non-Small Cell Carcinoma

Sites in Memphis, Knoxville +633 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04267848·Phase 3·Recruiting·Listed Feb 2020

Apply to this trial

Evaluation Of Cardiovascular Health Outcomes Among Survivors 2

for Health Behavior

1 location in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: 26+

Code: NCT07245420·Recruiting·Listed Nov 2025

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Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

for Breast Cancer

Sites in Memphis, Knoxville +1103 more locations

Sponsor: NRG Oncology

Sex: Female·Age: 18 - 60

Code: NCT05879926·Phase 3·Recruiting·Listed May 2023

Apply to this trial

The HOPE Biobank Resource (BMT CTN 2402 HOPE)

for Aplastic Anemias

Sites in Nashville +5 more locations

Sponsor: Medical College of Wisconsin

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07227155·Recruiting·Listed Nov 2025

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Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease

for Stage III Colon Cancer

Sites in Nashville, Memphis +920 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT05174169·Phase 2, Phase 3·Recruiting·Listed Dec 2021

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Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

for Anatomic Stage II Breast Cancer AJCC v8

Sites in Nashville, Memphis +774 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT05812807·Phase 3·Recruiting·Listed Apr 2023

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Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

for Chronic Lymphocytic Leukemia

Sites in Memphis, Collierville +296 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04269902·Phase 3·Recruiting·Listed Feb 2020

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ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab

for Anatomic Stage I Breast Cancer AJCC v8

Sites in Memphis, Knoxville +583 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06876714·Phase 3·Recruiting·Listed Mar 2025

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Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

for Advanced Lung Non-Squamous Non-Small Cell Carcinoma

Drug: Bevacizumab

Sites in Memphis, Collierville +326 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04181060·Phase 3·Recruiting·Listed Nov 2019

Apply to this trial

Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease

for Sickle Cell Disease

1 location in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: 8 - 17

Code: NCT07226219·Phase 1·Recruiting·Listed Nov 2025

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Understanding Practices of Lactation and Infant Feeding Together With Women With HIV in the United States

for HIV-1-infection

Sites in Memphis +10 more locations

Sponsor: International Maternal Pediatric Adolescent AIDS Clinical Trials Group

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07293559·Recruiting·Listed Dec 2025

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Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials

for Breast Cancer, NOS

Sites in Kingsport & Bristol

Sponsor: Eastern Cooperative Oncology Group

Sex: All·Age: 18 - 39

Code: NCT05108298·Recruiting·Listed Nov 2021

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Impact of Intraoperative Oxygenation Practices on Patient Outcomes

for Surgeries Undergoing General Anesthesia

Sites in Nashville +3 more locations

Sponsor: Frederic T Billings IV

Sex: All·Age: 18+

Code: NCT07224243·Recruiting·Listed Nov 2025

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Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer

for Anatomic Stage II Breast Cancer AJCC v8

Drug: Durvalumab

Sites in Memphis, Knoxville +525 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06058377·Phase 3·Recruiting·Listed Sep 2023

Apply to this trial

Metastatic Ewing's Trial Testing Schedule Enhancement to Improve Outcomes

for Metastatic Ewing Sarcoma

Sites in Nashville +16 more locations

Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All·Age: 1+

Code: NCT07194044·Phase 1·Recruiting·Listed Sep 2025

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Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial

for Extensive Stage Lung Small Cell Carcinoma

Drug: Atezolizumab

Sites in Memphis +272 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04402788·Phase 2, Phase 3·Recruiting·Listed May 2020

Apply to this trial

Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

for Childhood Extracranial Germ Cell Tumor

Sites in Nashville, Memphis +385 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: All ages

Code: NCT03067181·Phase 3·Recruiting·Listed Mar 2017

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Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

for Smoldering Plasma Cell Myeloma

Drug: Daratumumab

Sites in Nashville +487 more locations

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT03937635·Phase 3·Recruiting·Listed May 2019

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Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study

for Muscle Invasive Bladder Urothelial Carcinoma

Sites in Nashville +446 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05987241·Phase 2, Phase 3·Recruiting·Listed Aug 2023

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Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps

for Adenocarcinoma of the Colon

Sites in Memphis +364 more locations

Sponsor: NRG Oncology

Sex: All·Age: 45 - 70

Code: NCT05080673·Recruiting·Listed Oct 2021

Apply to this trial