Paid Clinical Trials in Worcester, MA

As of August 2026, 204 paid clinical trials are recruiting in Worcester, Massachusetts. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 13, 2026.

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174 clinical trials

A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML

for Acute Myeloid Leukemia

Drug: Venetoclax

Sites in Worcester, Boston +42 more locations

Sponsor: Kura Oncology, Inc.

Sex: All·Age: 18+

Code: NCT05735184·Phase 1·Recruiting·Listed Feb 2023

Apply to this trial

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

for Cancer, Metastatic

Sites in Worcester +66 more locations

Sponsor: Massive Bio, Inc.

Sex: All·Age: All ages

Code: NCT03452774·Recruiting·Listed Mar 2018

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A Study to Learn About the Safety, Tolerability, and Immunogenicity of a Fifth Dose of 6-Valent OspA-Based Lyme Disease Vaccine

for Lyme Disease

Sites in Worcester +18 more locations

Sponsor: Pfizer

Sex: All·Age: 7+·Accepts healthy volunteers

Code: NCT07500506·Phase 3·Recruiting·Listed Mar 2026

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A Study to Evaluate the Long-term Safety and Tolerability of KarXT and KarX-EC for the Treatment of Schizophrenia and Autism-Related Irritability in Adolescents, Respectively

for Schizophrenia

Drug: KarXT

Sites in Worcester, Lexington +49 more locations

Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Sex: All·Age: 5 - 17

Code: NCT07424404·Phase 3·Recruiting·Listed Feb 2026

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ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response

for Major Depressive Disorder (MDD)

Sites in Worcester, Watertown +20 more locations

Sponsor: ACADIA Pharmaceuticals Inc.

Sex: All·Age: 18 - 65

Code: NCT07284667·Phase 2·Recruiting·Listed Dec 2025

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A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Schizophrenia in Adolescents (EMERGENT TEEN)

for Schizophrenia

Drug: KarXT

Sites in Worcester, Boston +19 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 13 - 17

Code: NCT07288567·Phase 3·Recruiting·Listed Dec 2025

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Study of MRM-3379 in Male Participants With Fragile X Syndrome (BLOOM)

for Fragile X Syndrome

Sites in Worcester, Boston +13 more locations

Sponsor: Mirum Pharmaceuticals, Inc.

Sex: Male·Age: 13 - 45

Code: NCT07209462·Phase 2·Recruiting·Listed Oct 2025

Apply to this trial

Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Gastric or Esophageal Cancer.

for Esophageal Cancer

Sites in Worcester, Boston +13 more locations

Sponsor: SOFIE

Sex: All·Age: 18+

Code: NCT07217704·Phase 3·Recruiting·Listed Oct 2025

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Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Pancreatic Ductal Adenocarcinoma (PDAC)

for Pancreatic Ductal Adenocarcinoma (PDAC)

Sites in Worcester, Boston +13 more locations

Sponsor: SOFIE

Sex: All·Age: 18+

Code: NCT07217717·Phase 3·Recruiting·Listed Oct 2025

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A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

for Non-Small Cell Lung Cancer (NSCLC)

Drug: Sotorasib

Sites in Worcester +18 more locations

Sponsor: Amgen

Sex: All·Age: 18 - 100

Code: NCT05920356·Phase 3·Recruiting·Listed Jun 2023

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A Follow-up Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia

for Immune Thrombocytopenic Purpura (ITP)

Sites in Worcester, Boston +18 more locations

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06948318·Phase 3·Recruiting·Listed Apr 2025

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A Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia

for Immune Thrombocytopenic Purpura (ITP)

Sites in Worcester, Boston +22 more locations

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06722235·Phase 3·Recruiting·Listed Dec 2024

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Post-market Surveillance Study of the BD® WavelinQ™ EndoAVF System

for Kidney Disease, End-Stage

Sites in Worcester, Springfield +12 more locations

Sponsor: C. R. Bard

Sex: All·Age: 18+

Code: NCT04634916·Recruiting·Listed Nov 2020

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An Open Label Clinical Study to Evaluate Tanruprubart (Also Commonly Known as ANX005) in Participants With Guillain-Barré Syndrome (FORWARD Study)

for Guillain-Barre Syndrome

Sites in Worcester +11 more locations

Sponsor: Annexon, Inc.

Sex: All·Age: 12 - 85

Code: NCT07020819·Phase 3·Recruiting·Listed Jun 2025

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A Study of Inlexisertib (DCC-3116) in Combination With Anticancer Therapies in Participants With Advanced Malignancies

for GIST

Sites in Worcester +10 more locations

Sponsor: Deciphera Pharmaceuticals, LLC

Sex: All·Age: 18+

Code: NCT05957367·Phase 1, Phase 2·Recruiting·Listed Jul 2023

Apply to this trial

RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus

for Systemic Lupus Erythematosus

Sites in Worcester, Boston +17 more locations

Sponsor: Cabaletta Bio

Sex: All·Age: 18 - 65

Code: NCT06121297·Phase 1, Phase 2·Recruiting·Listed Nov 2023

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A Study to Evaluate the Clinical Outcomes of Efgartigimod PH20 SC in Adults With New-onset Generalized Myasthenia Gravis (gMG)

for New Onset Generalized Myasthenia Gravis (gMG)

Drug: Efgartigimod PH20 SC

Sites in Worcester +17 more locations

Sponsor: argenx

Sex: All·Age: 18+

Code: NCT06909214·Phase 4·Recruiting·Listed Apr 2025

Apply to this trial

52 Week Study + 24-Month Long-Term Extension of Safety, PK, & Efficacy of XYOSTED® for Testosterone Replacement in Male Adolescents With Hypogonadism

for Hypogonadism, Male

Sites in Worcester, Boston +18 more locations

Sponsor: Halozyme Therapeutics

Sex: Male·Age: 12 - 17

Code: NCT06689085·Phase 3·Recruiting·Listed Nov 2024

Apply to this trial

AS-1763 in Patients With Previously Treated CLL/SLL or Non-Hodgkin Lymphoma

for B-cell Malignancy

Sites in Worcester +12 more locations

Sponsor: Carna Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT05602363·Phase 1·Recruiting·Listed Nov 2022

Apply to this trial

SAfety of Regional Citrate Anticoagulation (SARCA Study)

for Acute Kidney Injury

Sites in Worcester +5 more locations

Sponsor: Fresenius Medical Care North America

Sex: All·Age: 18+

Code: NCT05339139·Phase 3·Recruiting·Listed Apr 2022

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A Study to Learn About the Safety of Taking an Additional Dose of the Medicine Rimegepant in Adults With Migraine

for Acute Treatment of Migraine

Drug: Rimegepant

Sites in Worcester +10 more locations

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07609914·Phase 4·Recruiting·Listed May 2026

Apply to this trial

Phase 2 Study of SAT-3247 in Pediatric Ambulatory Patients

for Duchenne Muscular Dystrophy

Sites in Worcester +6 more locations

Sponsor: Satellos Bioscience, Inc.

Sex: Male·Age: 7 - 9

Code: NCT07287189·Phase 2·Recruiting·Listed Dec 2025

Apply to this trial

A Study Evaluating the Real-World Experience of Givinostat in Patients With Duchenne Muscular Dystrophy

for Duchene Muscular Dystrophy

Drug: Givinostat

Sites in Worcester, Boston +7 more locations

Sponsor: ITF Therapeutics LLC

Sex: All·Age: 6+

Code: NCT07127978·Recruiting·Listed Aug 2025

Apply to this trial

SAINT in Postpartum Depression (PPD)

for Postpartum Depression (PPD)

Sites in Worcester +3 more locations

Sponsor: Magnus Medical

Sex: Female·Age: 18 - 45

Code: NCT07210255·Recruiting·Listed Oct 2025

Apply to this trial

Validation of Chlamydia Diagnostic Codes in TriNetX US EHR Data

for Chlamydial Infections

1 location in Worcester

Sponsor: Sanofi

Sex: All·Age: 14 - 44

Code: NCT07094373·Recruiting·Listed Jul 2025

Apply to this trial

Radiation Free Study

for Aortic Aneurysm

Sites in Worcester, Boston +3 more locations

Sponsor: Philips Clinical & Medical Affairs Global

Sex: All·Age: 18+

Code: NCT06549348·Recruiting·Listed Aug 2024

Apply to this trial

Dexmedetomidine Transdermal Systems (DMTS) Treatment for Agitation Associated With Dementia of the Alzheimer's Type

for Agitation

Sites in Worcester +5 more locations

Sponsor: Teikoku Pharma USA, Inc.

Sex: All·Age: All ages

Code: NCT06052254·Phase 2·Recruiting·Listed Sep 2023

Apply to this trial

Observational Study of THC Concentrations in Acute Cannabis-induced CNS Depression

for Acute Cannabis-induced CNS Depression

Sites in Worcester +2 more locations

Sponsor: Anebulo Pharmaceuticals

Sex: All·Age: All ages

Code: NCT06017622·Recruiting·Listed Aug 2023

Apply to this trial

A Study Comparing KB803 and Matched Placebo in Patients With Dystrophic Epidermolysis Bullosa

for Dystrophic Epidermolysis Bullosa

Sites in Worcester +4 more locations

Sponsor: Krystal Biotech, Inc.

Sex: All·Age: 6 Months+

Code: NCT07016750·Phase 3·Recruiting·Listed Jun 2025

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A Double Blind, Randomized Controlled Study, Evaluating the Safety and Efficacy of RD2 Ver.02 For the Management of Anal Fistulas

for Anal Fistula

Sites in Worcester +7 more locations

Sponsor: RedDress Ltd.

Sex: All·Age: 18+

Code: NCT05641844·Recruiting·Listed Dec 2022

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A Study to Assess Adverse Events and Change in Disease Activity in Participants With Platinum-Resistant Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha Expression Treated With Intravenously (IV) Infused Mirvetuximab Soravtansine

for Advanced High-Grade Epithelial Ovarian Cancer

Sites in Worcester +6 more locations

Sponsor: AbbVie

Sex: Female·Age: 18+

Code: NCT06682988·Phase 2·Recruiting·Listed Nov 2024

Apply to this trial

Trial to Visualize the Ureters With Nizaracianine Triflutate in Adults Undergoing Abdominopelvic Surgery

for Injury of Ureter During Surgery (Disorder)

Sites in Worcester +4 more locations

Sponsor: Curadel Surgical Innovations, Inc.

Sex: All·Age: 18+

Code: NCT06101745·Phase 2, Phase 3·Recruiting·Listed Oct 2023

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Performance of SGM-101 for the Delineation of Primary and Recurrent Tumor and Metastases in Patients Undergoing Surgery for Colorectal Cancer

for Colorectal Neoplasms

Sites in Worcester, Boston +4 more locations

Sponsor: Surgimab

Sex: All·Age: 18+

Code: NCT03659448·Phase 3·Recruiting·Listed Sep 2018

Apply to this trial

Preliminary Trial of an Avatar Guided Digital Intervention for Emerging Adults

for Binge Alcohol Consumption

Sites in Worcester & Marlborough

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 18 - 29

Code: NCT07418047·Recruiting·Listed Feb 2026

Apply to this trial

Changing Lives and Changing Outcomes-9 at Worcester Recovery Center and Hospital

for Serious Mental Illness

1 location in Worcester

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07359157·Recruiting·Listed Jan 2026

Apply to this trial

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

for Lung Non-Small Cell Carcinoma

Sites in Worcester, Foxborough +633 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04267848·Phase 3·Recruiting·Listed Feb 2020

Apply to this trial

Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

for Advanced Lung Non-Squamous Non-Small Cell Carcinoma

Drug: Bevacizumab

Sites in Worcester +327 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04181060·Phase 3·Recruiting·Listed Nov 2019

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Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial

for Extensive Stage Lung Small Cell Carcinoma

Drug: Atezolizumab

Sites in Worcester, Lowell +268 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04402788·Phase 2, Phase 3·Recruiting·Listed May 2020

Apply to this trial

ARISe at UMass Chan

for Vaccination

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07236034·Recruiting·Listed Nov 2025

Apply to this trial

Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

for Childhood Extracranial Germ Cell Tumor

Sites in Worcester, Springfield +385 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: All ages

Code: NCT03067181·Phase 3·Recruiting·Listed Mar 2017

Apply to this trial