Rituximab, Prednisone, Cyclophosphamide, Doxorubicin, Vincristine, and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Previously Untreated Mantle Cell Lymphoma

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
National Cancer Institute (NCI)
Study ID
NCT00070447
Phase
PHASE2
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • rituximab — BIOLOGICAL
  • cyclophosphamide — DRUG
  • doxorubicin hydrochloride — DRUG
  • prednisone — DRUG
  • vincristine sulfate — DRUG
  • yttrium Y 90 ibritumomab tiuxetan — RADIATION

Study Details

RATIONALE: Monoclonal antibodies, such as rituximab and yttrium Y 90 ibritumomab tiuxetan, can locate cancer cells and either kill them or deliver radioactive cancer-killing substances to them without harming normal cells. Drugs used in chemotherapy, such as prednisone, cyclophosphamide, doxorubicin, and vincristine, use different ways to stop cancer cells from dividing so they stop growing or die. Combining monoclonal antibody therapy with chemotherapy may kill more cancer cells. PURPOSE: This phase II trial is studying how well giving rituximab and combination chemotherapy together with yttrium Y 90 ibritumomab tiuxetan works in treating patients with previously untreated mantle cell lymphoma.

Key Dates

Start date
Nov 30, 2003
Status verified
Oct 2004
Completion
Jun 30, 2006

Study Design

Primary purpose
TREATMENT

Locations (81)

FacilityCityStateZIPSite coordinators
Comprehensive Cancer Center at University of Alabama at BirminghamBirminghamAlabama35294-3300-
CCOP - Mayo Clinic Scottsdale Oncology ProgramScottsdaleArizona85259-5404-
City of Hope Comprehensive Cancer CenterDuarteCalifornia91010-3000-
Veterans Affairs Medical Center - Palo AltoPalo AltoCalifornia94304-1290-
Stanford Cancer Center at Stanford University Medical CenterStanfordCalifornia94305-5216-
CCOP - Colorado Cancer Research Program, IncorporatedDenverColorado80224-
CCOP - Christiana Care Health ServicesNewarkDelaware19713-
MBCCOP - Howard University Cancer CenterWashington D.C.District of Columbia20060-
Veterans Affairs Medical Center - GainesvilleGainesvilleFlorida32608-1197-
Veterans Affairs Medical Center - MiamiMiamiFlorida33125-
H. Lee Moffitt Cancer Center and Research Institute at University of South FloridaTampaFlorida33612-9497-
Veterans Affairs Medical Center - Tampa (Haley)TampaFlorida33612-
Winship Cancer Institute of Emory UniversityAtlantaGeorgia30322-
Veterans Affairs Medical Center - Atlanta (Decatur)DecaturGeorgia30033-
Robert H. Lurie Comprehensive Cancer Center at Northwestern UniversityChicagoIllinois60611-
Veterans Affairs Medical Center - Lakeside ChicagoChicagoIllinois60611-4494-
CCOP - Central IllinoisDecaturIllinois62526-
CCOP - EvanstonEvanstonIllinois60201-
CCOP - Illinois Oncology Research AssociationPeoriaIllinois61615-7828-
Swedish-American Regional Cancer CenterRockfordIllinois61104-2315-
CCOP - Carle Cancer CenterUrbanaIllinois61801-
Indiana University Cancer CenterIndianapolisIndiana46202-5289-
Veterans Affairs Medical Center - Indianapolis (Roudebush)IndianapolisIndiana46202-
CCOP - Northern Indiana CR ConsortiumSouth BendIndiana46601-
CCOP - Cedar Rapids Oncology ProjectCedar RapidsIowa52403-1206-
CCOP - Iowa Oncology Research AssociationDes MoinesIowa50309-1016-
John Stoddard Cancer Center at Iowa Lutheran HospitalDes MoinesIowa50316-2301-
John Stoddard Cancer Center at Iowa Methodist Medical CenterDes MoinesIowa50309-
Mercy Cancer Center at Mercy Medical Center - Des MoinesDes MoinesIowa50314-
Burgess Health CenterOnawaIowa51040-
CCOP - WichitaWichitaKansas67214-3882-
Veterans Affairs Medical Center - WichitaWichitaKansas67218-
CCOP - OchsnerNew OrleansLouisiana70121-
MBCCOP - LSU Health Sciences CenterNew OrleansLouisiana70112-
Beth Israel Deaconess Medical CenterBostonMassachusetts02215-
Cancer Center at Tufts - New England Medical CenterBostonMassachusetts02111-
CCOP - Michigan Cancer Research ConsortiumAnn ArborMichigan48106-
CCOP - KalamazooKalamazooMichigan49007-3731-
CCOP - DuluthDuluthMinnesota55805-
University of Minnesota Cancer CenterMinneapolisMinnesota55455-
Veterans Affairs Medical Center - MinneapolisMinneapolisMinnesota55417-2399-
Mayo Clinic Cancer CenterRochesterMinnesota55905-
CCOP - Metro-MinnesotaSaint Louis ParkMinnesota55416-
CCOP - Missouri Valley Cancer ConsortiumOmahaNebraska68106-
Veterans Affairs Medical Center - OmahaOmahaNebraska68105-
Midlands Cancer Center at Midlands Community HospitalPapillionNebraska68128-4157-
CCOP - Southern Nevada Cancer Research FoundationLas VegasNevada89106-
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical CenterLebanonNew Hampshire03756-0002-
Veterans Affairs Medical Center - East OrangeEast OrangeNew Jersey07018-
CCOP - Northern New JerseyHackensackNew Jersey07601-
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical SchoolNew BrunswickNew Jersey08903-
MBCCOP - University of New Mexico HSCAlbuquerqueNew Mexico87131-
Veterans Affairs Medical Center - BrooklynBrooklynNew York11209-
NYU Cancer Institute at New York University Medical CenterNew YorkNew York10016-
Veterans Affairs Medical Center - New YorkNew YorkNew York10010-
Albert Einstein Cancer Center at Albert Einstein College of MedicineThe BronxNew York10461-
MBCCOP-Our Lady of Mercy Cancer CenterThe BronxNew York10466-
CCOP - Merit Care HospitalFargoNorth Dakota58122-
Cleveland Clinic Taussig Cancer CenterClevelandOhio44195-
MetroHealth's Cancer Care Center at MetroHealth Medical CenterClevelandOhio44109-
CCOP - ColumbusColumbusOhio43206-
CCOP - Toledo Community HospitalToledoOhio43623-3456-
CCOP - OklahomaTulsaOklahoma74136-
CCOP - Geisinger Clinic and Medical CenterDanvillePennsylvania17822-2001-
Penn State Cancer Institute at Milton S. Hershey Medical CenterHersheyPennsylvania17033-0850-
Abramson Cancer Center of the University of PennsylvaniaPhiladelphiaPennsylvania19104-
Fox Chase Cancer CenterPhiladelphiaPennsylvania19111-2497-
Hahnemann University HospitalPhiladelphiaPennsylvania19102-1192-
Hillman Cancer Center at University of Pittsburgh Cancer InstitutePittsburghPennsylvania15236-
Veterans Affairs Medical Center - PittsburghPittsburghPennsylvania15240-
CCOP - MainLine HealthWynnewoodPennsylvania19096-
CCOP - Sioux Community Cancer ConsortiumSioux FallsSouth Dakota57104-
Vanderbilt-Ingram Cancer Center at Vanderbilt Medical CenterNashvilleTennessee37232-6307-
Veterans Affairs Medical Center - Tennessee Valley Healthcare System - Nashville CampusNashvilleTennessee37212-2637-
CCOP - Scott and White HospitalTempleTexas76508-
CCOP - St. Vincent Hospital Cancer Center, Green BayGreen BayWisconsin54301-
University of Wisconsin Comprehensive Cancer CenterMadisonWisconsin53792-0001-
Veterans Affairs Medical Center - MadisonMadisonWisconsin53705-
CCOP - Marshfield Clinic Research FoundationMarshfieldWisconsin54449-
Medical College of Wisconsin Cancer CenterMilwaukeeWisconsin53226-3596-
Veterans Affairs Medical Center - Milwaukee (Zablocki)MilwaukeeWisconsin53295-

Find similar trials in Birmingham, AL

By research site
Comprehensive Cancer Center at University of Alabama at Birmingham· Birmingham, ALCCOP - Mayo Clinic Scottsdale Oncology Program· Scottsdale, AZCity of Hope Comprehensive Cancer Center· Duarte, CAVeterans Affairs Medical Center - Palo Alto· Palo Alto, CAStanford Cancer Center at Stanford University Medical Center· Stanford, CACCOP - Colorado Cancer Research Program, Incorporated· Denver, CO

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