Rituximab in Treating Patients With Refractory or Relapsed Primary CNS Lymphoma

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Study ID
NCT00072449
Phase
PHASE2
Status
Terminated

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

RATIONALE: Monoclonal antibodies, such as rituximab, can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells. PURPOSE: Phase II trial to study the effectiveness of rituximab in treating patients who have refractory or relapsed primary CNS lymphoma.

Key Dates

Start date
May 31, 2004
Status verified
Jun 2013
Primary completion
Mar 31, 2009
Completion
Jun 30, 2010

Study Design

Enrollment
12 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Rituximab monotherapy
    Rituximab administered at a dose of 375mg/m2 as a single IV infusion every week for up to 8 weeks

Primary Outcome Measure

Radiographic Response [ Time Frame: 1 month, 2 months and then q3months ]

Locations (9)

FacilityCityStateZIPSite coordinators
Lurleen Wallace Comprehensive Cancer at University of Alabama - BirminghamBirminghamAlabama35294-
H. Lee Moffitt Cancer Center and Research Institute at University of South FloridaTampaFlorida33612-9497-
Winship Cancer Institute of Emory UniversityAtlantaGeorgia30322-
Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsBaltimoreMaryland21231-2410-
Massachusetts General HospitalBostonMassachusetts02114-
Josephine Ford Cancer Center at Henry Ford HospitalDetroitMichigan48202-
Wake Forest University Comprehensive Cancer CenterWinston-SalemNorth Carolina27157-1096-
Cleveland Clinic Taussig Cancer CenterClevelandOhio44195-
Abramson Cancer Center of the University of PennsylvaniaPhiladelphiaPennsylvania19104-4283-

Find similar trials in Birmingham, AL

By research site
Lurleen Wallace Comprehensive Cancer at University of Alabama - Birmingham· Birmingham, ALH. Lee Moffitt Cancer Center and Research Institute at University of South Florida· Tampa, FLWinship Cancer Institute of Emory University· Atlanta, GASidney Kimmel Comprehensive Cancer Center at Johns Hopkins· Baltimore, MDMassachusetts General Hospital· Boston, MAJosephine Ford Cancer Center at Henry Ford Hospital· Detroit, MI

Related Studies