Treatment of HER2-Positive Metastatic Breast Cancer With Herceptin and Bevacizumab (Antibodies Against HER2 and VEGF)

Part of paid clinical trials in Alhambra, California.

Sponsor
Translational Oncology Research International
Study ID
NCT00095706
Phase
PHASE1/PHASE2
Status
Completed

Conditions

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

Study Details

The purpose of this study is to evaluate the safety and effectiveness of combined treatment with trastuzumab (Herceptin) and bevacizumab (anti-VEGF antibody) in patients with HER2-positive metastatic breast cancer.

Key Dates

First listed
Nov 8, 2004
Start date
Jun 30, 2003
Status verified
Sep 2015
Primary completion
Apr 30, 2007
Completion
Jan 31, 2012

Study Design

Enrollment
50 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Primary Outcome Measure

To establish the maximum tolerated dose (MTD) or recommended phase II dose of rhuMAb VEGF (bevacizumab) administered intravenously every 14 days to patients with HER2-amplified relapsed or metastatic breast cancer receiving concomitant Herceptin therapy

Locations (18)

FacilityCityStateZIPSite coordinators
Central Hematology Oncology Medical Group, Inc.AlhambraCalifornia91801-
Comprehensive Blood and Cancer CenterBakersfieldCalifornia93309-
Virginia K. Crosson Cancer CenterFullertonCalifornia92835-
Pacific Shores Medical GroupLong BeachCalifornia90813-
UCLA Medical CenterLos AngelesCalifornia90095-
North Valley Hematology/Oncology Medical GroupNorthridgeCalifornia91328-
Ventura County Hematology-Oncology SpecialistsOxnardCalifornia93030-
Wilshire Oncology Medical Group, Inc.PomonaCalifornia91767-
Cancer Care Associates Medical Group, Inc.Redondo BeachCalifornia90277-
Sansum Santa Barbara Medical Foundation ClinicSanta BarbaraCalifornia93105-
Santa Barbara Hematology Oncology Medical Group, Inc.Santa BarbaraCalifornia93105-
San Diego Cancer CenterVistaCalifornia92081-
Cancer Institute of Florida, P.A.OrlandoFlorida32804-
Northeast Georgia Cancer Care, LLCAthensGeorgia30607-
Suburban Hematology-Oncology Associates, P.A.LawrencevilleGeorgia30045-
Northwest Georgia Oncology Centers, P.C.MariettaGeorgia30060-
Oncology Hematology Associates of Central Illinois, P.C.PeoriaIllinois61615-
Comprehensive Cancer Centers of NevadaLas VegasNevada89109-

Find similar trials in Alhambra, CA

By condition
Breast cancer
By specialty
OncologyBreast oncologyWomen's health
By research site
Central Hematology Oncology Medical Group, Inc.· Alhambra, CAComprehensive Blood and Cancer Center· Bakersfield, CAVirginia K. Crosson Cancer Center· Fullerton, CAPacific Shores Medical Group· Long Beach, CAUCLA Medical Center· Los Angeles, CANorth Valley Hematology/Oncology Medical Group· Northridge, CA

Related Studies