Carboplatin and Gemcitabine With Bevacizumab Every 2 Weeks for Stage IIIb/IV Non-small Cell Lung Cancer

Part of paid clinical trials in Minneapolis, Minnesota.

Sponsor
Masonic Cancer Center, University of Minnesota
Study ID
NCT00400803
Phase
PHASE2
Status
Completed

Conditions

  • Carcinoma, Non-Small-Cell Lung

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Gemcitabine, Carboplatin, Bevacizumab — DRUG
    Patients will be treated with Gemcitabine 2000mg/m\^2 intravenously (IV) over 30 minutes, followed by Carboplatin AUC= 3 IV over 30 minutes and Bevacizumab 10 mg/kg IV over 90 minutes 1st infusion, 60 minutes 2nd infusion and 30 minutes for the following infusions. Cycles will be repeated every 2 weeks for a maximum of 6 cycles of therapy. Bevacizumab will continue to be given until disease progression.

Study Details

The purpose of this study is to determine whether treatment with carboplatin and gemcitabine combined with bevacizumab every two weeks will provide increased survival.

Key Dates

First listed
Nov 17, 2006
Start date
Mar 31, 2007
Status verified
Dec 2017
Primary completion
May 31, 2010
Completion
May 31, 2010

Study Design

Enrollment
38 participants (actual)
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Patients with Stage IIIb/IV Non-Small Cell Lung Cancer
    Patients treated with Gemcitabine 2000mg/m\^2 intravenously (IV) over 30 minutes, followed by Carboplatin AUC= 3 IV over 30 minutes and Bevacizumab 10 mg/kg IV over 90 minutes 1st infusion, 60 minutes 2nd infusion and 30 minutes for the following infusions. Cycles will be repeated every 2 weeks for a maximum of 6 cycles of therapy. Bevacizumab will continue to be given until disease progression.

Primary Outcome Measure

Time to Progression [ Time Frame: From Enrollment Through 2 Years ]

Locations (2)

FacilityCityStateZIPSite coordinators
Hubert H. Humphrey Cancer CenterMinneapolisMinnesota55422-
University of Minnesota Cancer CenterMinneapolisMinnesota55455-

Find similar trials in Minneapolis, MN

By research site
Hubert H. Humphrey Cancer Center· Minneapolis, MNUniversity of Minnesota Cancer Center· Minneapolis, MN

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