Irinotecan and Etoposide in Treating Patients With Recurrent, Locally Advanced, or Metastatic Breast Cancer

Part of paid clinical trials in Tucson, Arizona.

Sponsor
University of Arizona
Study ID
NCT00693719
Phase
PHASE2
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
N/A - 120 Years
Healthy Volunteers
Not accepted

Interventions

  • Etoposide — DRUG
    50 mg PO x14 days followed by 2 weeks off, 28 day/Cycle
  • Irinotecan hydrochloride — DRUG
    Irinotecan 100 mg/m2 IV days 1 and 15, 28 day/Cycle

Study Details

RATIONALE: Drugs used in chemotherapy, such as irinotecan and etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving irinotecan together with etoposide works in treating patients with recurrent, locally advanced, or metastatic breast cancer.

Key Dates

Start date
Aug 31, 2007
Status verified
Aug 2013
Primary completion
Dec 31, 2012
Completion
May 31, 2013

Study Design

Enrollment
31 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Etoposide and Irinotecan hydrochloride
    Irinotecan 100 mg/m2 IV days 1 and 15. Etoposide 50 mg PO x14 days followed by 2 weeks off.

Primary Outcome Measure

Median Time to Progression [ Time Frame: Measured time from the start of treatment to the time the patient is first recorded as having disease progression or dies. If no progression or death while being followed via tumor assessment, censored at last date known alive, assesed up to 13 months ]

Locations (1)

FacilityCityStateZIPSite coordinators
Arizona Cancer Center at University of Arizona Health Sciences CenterTucsonArizona85724-5024-

Find similar trials in Tucson, AZ

By condition
Breast cancer
By specialty
OncologyBreast oncologyWomen's health
By research site
Arizona Cancer Center at University of Arizona Health Sciences Center· Tucson, AZ

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