Pazopanib Hydrochloride and Bevacizumab in Treating Patients With Previously Untreated Metastatic Kidney Cancer

Part of paid clinical trials in Westwood, Kansas.

Sponsor
Roswell Park Cancer Institute
Study ID
NCT01684397
Phase
PHASE1/PHASE2
Status
Active Not Recruiting

Conditions

  • Clear Cell Renal Cell Carcinoma
  • Stage IV Renal Cell Cancer

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Bevacizumab — BIOLOGICAL
    Given IV
  • Laboratory Biomarker Analysis — OTHER
    Correlative studies
  • Pazopanib Hydrochloride — DRUG
    Given PO
  • Pharmacological Study — OTHER
    Correlative studies

Study Details

This phase I/II trial studies the side effects and best dose of pazopanib hydrochloride and bevacizumab and to see how well they work in treating patients with previously untreated kidney cancer that has spread to other places in the body (metastatic). Pazopanib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Pazopanib hydrochloride may also stop the growth of tumor cells by blocking blood flow to the tumor. Monoclonal antibodies, such as bevacizumab, can prevent tumor growth by blocking the ability of tumor cells to grow and spread. Giving pazopanib hydrochloride together with bevacizumab may kill more tumor cells.

Key Dates

First listed
Sep 13, 2012
Start date
Nov 21, 2012
Status verified
Feb 2026
Primary completion
Aug 20, 2026
Completion
Aug 20, 2026

Study Design

Enrollment
51 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Treatment (pazopanib hydrochloride and bevacizumab)
    Patients receive pazopanib hydrochloride PO on days 1-28 and bevacizumab IV over 30-90 minutes on days 36 and 50. Courses repeat every 70 days in the absence of disease progression or unacceptable toxicity.

Primary Outcome Measure

Median PFS (Phase II) [ Time Frame: Up to 30 days post-treatment ]

Locations (5)

FacilityCityStateZIPSite coordinators
The University of Kansas Cancer CenterWestwoodKansas66205-
Karamanos Cancer InstituteDetroitMichigan482018-
Roswell Park Cancer InstituteBuffaloNew York14263-
University of Pittsburgh Cancer Institute (UPCI)PittsburghPennsylvania15232-
Medical College of WisconsinMilwaukeeWisconsin53226-

Find similar trials in Westwood, KS

By research site
The University of Kansas Cancer Center· Westwood, KSKaramanos Cancer Institute· Detroit, MIRoswell Park Cancer Institute· Buffalo, NYUniversity of Pittsburgh Cancer Institute (UPCI)· Pittsburgh, PAMedical College of Wisconsin· Milwaukee, WI

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