Study of Ruxolitinib in Pancreatic Cancer Patients (Janus 1)

Part of paid clinical trials in Avondale, Arizona.

Sponsor
Incyte Corporation
Study ID
NCT02117479
Phase
PHASE3
Status
Terminated

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Ruxolitinib — DRUG
    5 mg tablets to be administered by mouth twice daily (BID)
  • Placebo — DRUG
    5 mg tablets to be administered by mouth twice daily (BID)
  • Capecitabine — DRUG
    150 and 500 mg tablets to be administered by mouth twice daily (BID)

Study Details

Determining the efficacy, based upon overall survival, of ruxolitinib added to capecitabine for the treatment of advanced or metastatic pancreatic cancer.

Key Dates

Start date
Mar 31, 2014
Status verified
Mar 2019
Primary completion
Feb 29, 2016
Completion
Dec 31, 2016

Study Design

Enrollment
321 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Ruxolitinib plus capecitabine
  • Active Comparator: Placebo plus capecitabine

Primary Outcome Measure

Overall Survival (OS) [ Time Frame: Randomization until death due to any cause; up to the data cutoff 11FEB2016. ]

Locations (153)

FacilityCityStateZIPSite coordinators
-AvondaleArizona--
-ChandlerArizona--
-GilbertArizona--
-GlendaleArizona--
-MesaArizona--
-PhoenixArizona--
-ScottsdaleArizona--
-SurpriseArizona--
-TucsonArizona--
-Hot SpringsArkansas--
-JonesboroArkansas--
-AnaheimCalifornia--
-BakersfieldCalifornia--
-BerkeleyCalifornia--
-Beverly HillsCalifornia--
-Chula VistaCalifornia--
-CovinaCalifornia--
-DowneyCalifornia--
-El CajonCalifornia--
-FullertonCalifornia--
-GilroyCalifornia--
-GlendaleCalifornia--
-La MesaCalifornia--
-Long BeachCalifornia--
-Los AngelesCalifornia--
-LynwoodCalifornia--
-ModestoCalifornia--
-MontebelloCalifornia--
-NorthridgeCalifornia--
-OceansideCalifornia--
-OrangeCalifornia--
-Redondo BeachCalifornia--
-San DiegoCalifornia--
-San FranciscoCalifornia--
-San Luis ObispoCalifornia--
-Santa AnaCalifornia--
-Santa MariaCalifornia--
-Santa MonicaCalifornia--
-TorranceCalifornia--
-WhittierCalifornia--
-AuroraColorado--
-BoulderColorado--
-Colorado SpringsColorado--
-DenverColorado--
-Grand JunctionColorado--
-LongmontColorado--
-ThorntonColorado--
-New BritainConnecticut--
-New HavenConnecticut--
-SouthingtonConnecticut--
-TrumbullConnecticut--
-NewarkDelaware--
-Boca RatonFlorida--
-HollywoodFlorida--
-MiamiFlorida--
-Pembroke PinesFlorida--
-AtlantaGeorgia--
-AustellGeorgia--
-CarrolltonGeorgia--
-CartersvilleGeorgia--
-DouglasvilleGeorgia--
-MariettaGeorgia--
-NewnanGeorgia--
-RomeGeorgia--
-ThomasvilleGeorgia--
-Arlington HeightsIllinois--
-ChicagoIllinois--
-HinsdaleIllinois--
-NilesIllinois--
-UrbanaIllinois--
-GoshenIndiana--
-IndianapolisIndiana--
-TopekaKansas--
-AshlandKentucky--
-LouisvilleKentucky--
-MetairieLouisiana--
-New OrleansLouisiana--
-ScarboroughMaine--
-AnnapolisMaryland--
-BaltimoreMaryland--
-BethesdaMaryland--
-RockvilleMaryland--
-WorcesterMassachusetts--
-Ann ArborMichigan--
-DetroitMichigan--
-KalamazooMichigan--
-LansingMichigan--
-WoodburyMinnesota--
-BolivarMissouri--
-Kansas CityMissouri--
-St LouisMissouri--
-KalispellMontana--
-HastingsNebraska--
-OmahaNebraska--
-PapillionNebraska--
-Las VegasNevada--
-LebanonNew Hampshire--
-East OrangeNew Jersey--
-FarmingtonNew Mexico--
-BinghamtonNew York--
-Fresh MeadowsNew York--
-HudsonNew York--
-Johnson CityNew York--
-New YorkNew York--
-NyackNew York--
-RochesterNew York--
-The BronxNew York--
-DurhamNorth Carolina--
-Wake ForestNorth Carolina--
-Winston-SalemNorth Carolina--
-CantonOhio--
-ColumbusOhio--
-MiddletownOhio--
-OregonOhio--
-ToledoOhio--
-EugeneOregon--
-PortlandOregon--
-SpringfieldOregon--
-TualatinOregon--
-PhiladelphiaPennsylvania--
-CharlestonSouth Carolina--
-SenecaSouth Carolina--
-SpartanburgSouth Carolina--
-ChattanoogaTennessee--
-KnoxvilleTennessee--
-MemphisTennessee--
-NashvilleTennessee--
-ArlingtonTexas--
-AustinTexas--
-BeaumontTexas--
-BedfordTexas--
-Cedar ParkTexas--
-DallasTexas--
-DentonTexas--
-El PasoTexas--
-Fort WorthTexas--
-HoustonTexas--
-PlanoTexas--
-Round RockTexas--
-San AntonioTexas--
-TempleTexas--
-TylerTexas--
-WacoTexas--
-OgdenUtah--
-Salt Lake CityUtah--
-BlacksburgVirginia--
-RichmondVirginia--
-RoanokeVirginia--
-SalemVirginia--
-WythevilleVirginia--
-SeattleWashington--
-VancouverWashington--
-MadisonWisconsin--

Find similar trials in Avondale, AZ

By condition
Pancreatic cancer
By specialty
OncologyGI oncology

Related Studies