GI oncology Clinical Trials

Recruiting gi oncology studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat gi oncology. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting gi oncology studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting gi oncology trials

Within

The Impact of a Patient Decision Aid on Treatment Choices for Patients With an Unexpected Malignant Colorectal Polyp

for Shared Decision Making

Sponsor: Vejle Hospital

Sex: All·Age: 18+

Code: NCT05776381·Phase 2

Clinical Trial of DN022150 Combined With AG Chemotherapy as First-line Treatment for Locally Advanced or Metastatic Pancreatic Cancer With KRAS G12D Mutation

for Pancreatic Cancer

Sponsor: Jiangxi Kvvit Pharmaceutical Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07656376·Phase 2, Phase 3

Combination of CT and Ultrasound Radiomics Combined With Liquid Biopsy to Predict Neoadjuvant Chemotherapy Response in Patients With Locally Advanced Gastric Cancer

for Gastric Cancer

Sponsor: Liu Yang

Sex: All·Age: 18 - 80

Code: NCT07697079

TRANScriptional Pathways Of Surgical Pain Modulated by Music Therapy Exposure (TRANSPOSE)

for Surgery

1 site in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 50 - 80

Code: NCT07653594

Phase 2 Trial Of S-531011 With RadScopal In Previously Treated Metastatic Colorectal Cancer

for Phase II

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT07720115·Phase 2

Outside the Cage (OTC) Robotic Esophagectomy

for Esophageal Cancer

Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)

Sex: All·Age: 18+

Code: NCT06735638·Phase 1

Increasing CRC Screening in Community Health Centers Through Mobile Messaging Optimization

for Colorectal Cancer

4 sites incl. Boston

Sponsor: University of Colorado, Denver

Sex: All·Age: 45 - 75·Accepts healthy volunteers

Code: NCT07569250

GutCheck: Optimization of a Personalized Mobile Health App for Survivors of Gastrointestinal Cancer

for Gastrointestinal

Sponsor: Masonic Cancer Center, University of Minnesota

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07661017

Clinical Efficacy of Adebrelimab With or Without Apatinib Mesilate and SOX Neoadjuvant Therapy in Locally Advanced Gastric Cancer

for Gastric Cancer

Sponsor: Fujian Medical University

Sex: All·Age: 18 - 75

Code: NCT07314203·Phase 3

Oncolytic Virus Plus PD-1 Inhibitor to Patients With Advanced Pancreatic Cancer

for Pancreatic Cancer

Sponsor: Fudan University

Sex: All·Age: 18 - 80

Code: NCT06196671·Phase 2

Study Examining the Safety and Toxicity of Stereotactic Body Radiotherapy (SBRT) Followed by PCX12 Immunotherapy Delivered by Intratumoral Injection for the Treatment of Patients With Locally Advanced Pancreatic Adenocarcinoma (LAPC)

for Pancreatic Adenocarcinoma

1 site in Rochester

Sponsor: Haoming (Carl) Qiu

Sex: All·Age: 18+

Code: NCT06217666·Phase 1

Minimally Invasive Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Cancer, SOS5C Trial

for Barrett Esophagus

3 sites incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT07206589

Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates

for Rectal Adenocarcinoma

3 sites incl. Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 100

Code: NCT07292298·Phase 2

Apply to this trial

CPHARM - CRC Study

for Colorectal Cancer

Sponsor: Monash University Malaysia

Sex: All·Age: 50 - 75·Accepts healthy volunteers

Code: NCT07714291

Evaluation of the Administration of Artificial Nutrition by Feeding Jejunostomy During Neoadjuvant Treatment on Postoperative Morbidity in the Context of Esophageal or Stomach Cancer

for Esophageal Cancer

Sponsor: University Hospital, Bordeaux

Sex: All·Age: 18+

Code: NCT07584577

Apply to this trial

[18F]FTT Positron Emission Tomography/Computed Tomography to Predict Treatment Response in Patients Scheduled to Receive Gemcitabine, Cisplatin, and Durvalumab for Newly Diagnosed Cholangiocarcinoma

for Cholangiocarcinoma

1 site in Seattle

Sponsor: University of Washington

Sex: All·Age: 18+

Code: NCT07673341·Phase 2

Study to Evaluate the Diagnostic Performance of GEH300079 (68Ga) Injection PET/CT for Detection of PC in Patients With Colorectal, Gastric, Ovarian, or Pancreatic Cancers (PERISCOPE)

for Colorectal Cancer

1 site in Grand Rapids

Sponsor: GE Healthcare

Sex: All·Age: 18+

Code: NCT07219238·Phase 2, Phase 3

Apply to this trial

Transanal Irrigation for the Management of Early Low Anterior Resection Syndrome (LARS)

for Colorectal Cancer

1 site in Weston

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07219745

Pharmacokinetics Study of Larotinib in Subjects With Impaired Hepatic Function

for Esophageal Cancer

Sponsor: Sunshine Lake Pharma Co., Ltd.

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT05048368·Phase 1

ctDNA and Organ Preservation/Pathologic CR in Rectal Cancer

for Rectal Cancer

2 sites incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05629442

Yttrium-90 Radiation Segmentectomy for Hepatocellular Carcinoma

for Hepatocellular Carcinoma

1 site in San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 22+

Code: NCT07110233

A Study of Selective Internal Radiation Therapy for the Management of Chemotherapy-induced Thrombocytopenia With Splenomegaly in Adult Subjects With Gastrointestinal Cancer

for Gastrointestinal Cancer

Sponsor: Centre Georges Francois Leclerc

Sex: All·Age: 18+

Code: NCT07575854

External Beam Radiotherapy Combined With Endorectal High-dose-rate Brachytherapy in Elderly and Frail Patients With Rectal Cancer

for Rectal Cancer

Sponsor: University Hospital of Cologne

Sex: All·Age: 70+

Code: NCT06729645

Chemotherapy With or Without IMD10 (Focused Ultrasound) in the Treatment of Borderline Resectable or Locally Advanced Pancreatic Cancer

for Pancreatic Cancer

3 sites incl. Boston

Sponsor: IMGT Co., Ltd.

Sex: All·Age: 18 - 85

Code: NCT07325214

A Phase 1a/1b, First-Time-in-Human Study of CT-202, a Nectin-4 Directed Bispecific Antibody, in Participants With Recurring Triple Negative Breast, Colorectal, Urothelial Cancers

for Triple Negative Breast Cancer (TNBC)

Sponsor: Context Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT07545122·Phase 1

Nutritional Supplementation to Improve Colorectal Cancer Surgery

for Colorectal Cancer

Sponsor: Istituto Clinico Humanitas

Sex: All·Age: 18+

Code: NCT07599501

EYEMAX® Versus SPYGLASS™ DS for Biliary Stricture Diagnosis

for Cholangiocarcinoma

Sponsor: David KARSENTI

Sex: All·Age: 18 - 84

Code: NCT07620080

Improving Prognostication in Colon Cancer

for Colon Cancer

Sponsor: Universitaire Ziekenhuizen KU Leuven

Sex: All·Age: 18+

Code: NCT07673393

A Study of GFH276 Combined With Cetuximab or Chemotherapy in Participants With Solid Tumors and Pancreatic Ductal Adenocarcinoma (PDAC) Harboring RAS Mutation

for Advanced Solid Tumors Cancer

Sponsor: Genfleet Therapeutics (Shanghai) Inc.

Sex: All·Age: 18+

Code: NCT07678593·Phase 1, Phase 2

Trial of DN022150 Versus Chemotherapy in Previously Treated Advanced Pancreatic Cancer With KRAS G12D Mutation

for Pancreatic Cancer

Sponsor: Jiangxi Kvvit Pharmaceutical Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07689539·Phase 3

A Phase-II Clinical Trial of Radiotherapy to the Coeliac Plexus to Help Pain in Advanced Pancreatic Cancer

for Pancreatic Cancer

Sponsor: Royal Marsden NHS Foundation Trust

Sex: All·Age: 18+

Code: NCT07689955·Phase 2

SCARLET - Italian proSpeCtionAl obseRvationaL multicEntre Study on Treatment for recTal pT1 Cancer

for Rectal Cancer

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: All·Age: 18+

Code: NCT07695519

Evaluating Intermittent Fasting In Individuals At High Risk ForPancreatic Cancer Undergoing Screening

for Evaluating

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT07513116

Study of Perioperative NP137 and FOLFIRINOX in Resectable Pancreatic Cancer

for Pancreatic Cancer

1 site in Rochester

Sponsor: Aram Hezel

Sex: All·Age: 18+

Code: NCT06203821·Phase 1

e-Health Psychosocial Stress and Symptom Management (ePSMI) for Pancreatic Cancer Patients

for Pancreatic Cancer

1 site in Miami

Sponsor: University of Miami

Sex: All·Age: 18+

Code: NCT06893276

Neoadjuvant Intra-tumoral RP2 and FLOT in Gastroesophageal Adenocarcinoma

for Gastric Adenocarcinoma

1 site in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT07059611·Phase 2

Impact of Hypertrophy-oriented Resistance Training on Muscle Mass and Quality of Life in Patients With Unresectable Pancreatic Cancer

for Pancreatic Cancer

Sponsor: Universidad Europea de Madrid

Sex: All·Age: 18+

Code: NCT07470268

Superior Mesenteric Artery First Versus Standard Approach in Pancreaticoduodenectomy

for Pancreatic Adenocarcinoma

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18+

Code: NCT07547033

INtegrating Systematic PatIent-Reported Evaluations in Multi-Disciplinary Tumor Boards: The INSPIRE Study

for Breast Cancer

3 sites incl. Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18+

Code: NCT07671937

Patients With Hepatocellular Carcinoma (HCC)

for Hepatocellular Carcinoma

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: All·Age: 18+

Code: NCT07690683

Molecular Characterization of Tumor-Microenvironment Interactions to Predict Drug Resistance in Gastric and GEJ Adenocarcinoma

for Gastric Adenocarcinoma

Sponsor: Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis

Sex: All·Age: 18+

Code: NCT07692477

Testing Ivonescimab in Combination With Chemotherapy in Patients With Metastatic Colorectal Cancers Without Liver Metastases

for Metastatic Colorectal Cancer

Sponsor: UNICANCER

Sex: All·Age: 18+

Code: NCT07359456·Phase 2

Multidimensional Study Designed to Develop a Methodological Framework Based on MRI Data to Predict Pathological Complete Response (pCR) in Patients With Locally Advanced Rectal Cancer After Neoadjuvant Treatment

for Rectal Cancer

Sponsor: Institut du Cancer de Montpellier - Val d'Aurelle

Sex: All·Age: 18+

Code: NCT07404228

Allogeneic NK Cell Therapy Combined With Standard Maintenance Treatment in Advanced Solid Tumors

for NSCLC (Advanced Non-small Cell Lung Cancer)

Sponsor: BOE Technology Group Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07551778·Phase 1, Phase 2

Tovecimig Plus FOLFIRI in Second Line Metastatic Colorectal Cancer

for Colorectal Cancer

1 site in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07662031·Phase 2

Study of Occupational Risk Factors for Biliary and Pancreatic Cancers

for Biliary Tract Cancer

Sponsor: Centre Hospitalier Intercommunal Creteil

Sex: All·Age: 18+

Code: NCT07668024

A Study of Trastuzumab Deruxtecan (T-DXd) and Cetuximab in People With Colorectal Cancer

for Colorectal Cancer

7 sites incl. Basking Ridge

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT07691489·Phase 2

ctDNA and TEP Levels in Colon Cancer

for Colon Cancer

Sponsor: Institute of Oncology Ljubljana

Sex: All·Age: 18+

Code: NCT07701408

Sacituzumab Tirumotecan (Sac-TMT/SKB264) Plus Tagitanlimab (KL-A167) in Patients With Recurrent or Metastatic Esophageal Squamous Cell Carcinoma and Gastric/Gastroesophageal Junction Adenocarcinoma

for ESCC

Sponsor: Sun Yat-sen University

Sex: All·Age: 18+

Code: NCT07701681·Phase 2

Conversion Therapy With Retlirafusp Alfa Plus Chemotherapy in Gastric or Gastroesophageal Junction Adenocarcinoma

for Gastric Adenocarcinoma

Sponsor: Tang-Du Hospital

Sex: All·Age: 18 - 75

Code: NCT07709767·Phase 2

Comparison of Partial Stomach-Partitioning and Conventional Gastrojejunostomy for the Treatment of Gastric Outlet Obstruction in Advanced Gastric Cancer

for Gastric Cancer

Sponsor: Guangxi Medical University

Sex: All·Age: 18 - 75

Code: NCT07561073

Apply to this trial

QL1706 Combined With Standard Therapy for Conversion Therapy of Synchronous Liver Metastases From Colon Cancer: a Multicenter, Single-arm, Exploratory Study

for Colon Cancer

Sponsor: Fujian Medical University

Sex: All·Age: 18 - 70

Code: NCT07649473·Phase 2

Total Pancreatectomy With Islet Autotransplantation (TPIAT) for High-Risk Patients With Pancreatic Tumors

for Periampullary Neoplasms

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All·Age: 18+

Code: NCT07360119

Upfront Chemotherapy With Radiation Therapy (CRT) Followed by Chemotherapy in Localized Esophageal Adenocarcinoma

for Esophageal Adenocarcinoma

1 site in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07603375·Phase 2

Triton 1.5 Robotic System for Diagnostic Colonoscopy

for Colonoscopy

Sponsor: Neptune Medical

Sex: All·Age: 22+·Accepts healthy volunteers

Code: NCT07606963

Preoperative 3D Magnetic Resonance Elastography for Predicting Surgical Risk in Patients Undergoing Hepatectomy

for Hepatic Cancer

Sponsor: Second Affiliated Hospital of Xi'an Jiaotong University

Sex: All·Age: 18 - 80

Code: NCT07704203

Study on the Construction and Application of a Large Model Corpus for Pancreatic Cancer Based on Real Clinical Cases

for Pancreatic Cancer

Sponsor: Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

Sex: All·Age: 18+

Code: NCT07713823

COLOFLOW: Laser Speckle Contrast Imaging Versus Near-infrared Fluorescence Imaging With Indocyanine Green

for Leakage, Anastomotic

Sponsor: Leiden University Medical Center

Sex: All·Age: 18+

Code: NCT07720505

SAMe in Prevention of Oxaliplatin-associated Liver Injury

for Colorectal Cancer

2 sites in Los Angeles

Sponsor: Cedars-Sinai Medical Center

Sex: All·Age: 18+

Code: NCT06258525·Phase 2

Colorectal Cancer Screening in the Homeless

for Colorectal Cancer

1 site in Washington D.C.

Sponsor: George Washington University

Sex: All·Age: 45 - 75

Code: NCT07220018

GI oncology clinical trials — common questions

Are gi oncology clinical trials free to join?

Yes. Participating in a gi oncology clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a gi oncology clinical trial?

Each gi oncology study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a gi oncology trial near me?

Use the location controls above. We'll show recruiting gi oncology trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many gi oncology trials are recruiting right now?

We're currently tracking roughly 1008 recruiting gi oncology trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

GI oncology trials by city

Los Angeles, CA Duarte, CA Boston, MA Birmingham, AL Orange, CA San Francisco, CA Denver, CO Aurora, CO Tampa, FL Chicago, IL Cleveland, OH San Diego, CA

Conditions in this area

Colorectal cancer Metastatic colorectal cancer Colon cancer Rectal cancer Pancreatic cancer Gastric cancer Esophageal cancer Gastroesophageal junction cancer Liver cancer Biliary tract cancer Gastrointestinal cancer