GI oncology Clinical Trials

Recruiting gi oncology studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat gi oncology. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting gi oncology studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting gi oncology trials

Within

The Impact of a Patient Decision Aid on Treatment Choices for Patients With an Unexpected Malignant Colorectal Polyp

for Shared Decision Making

Sponsor: Vejle Hospital

Sex: All·Age: 18+

Code: NCT05776381·Phase 2

Clinical Trial of DN022150 Combined With AG Chemotherapy as First-line Treatment for Locally Advanced or Metastatic Pancreatic Cancer With KRAS G12D Mutation

for Pancreatic Cancer

Sponsor: Jiangxi Kvvit Pharmaceutical Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07656376·Phase 2, Phase 3

Combination of CT and Ultrasound Radiomics Combined With Liquid Biopsy to Predict Neoadjuvant Chemotherapy Response in Patients With Locally Advanced Gastric Cancer

for Gastric Cancer

Sponsor: Liu Yang

Sex: All·Age: 18 - 80

Code: NCT07697079

TRANScriptional Pathways Of Surgical Pain Modulated by Music Therapy Exposure (TRANSPOSE)

for Surgery

1 site in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 50 - 80

Code: NCT07653594

Development of a Risk Prediction Model for Immune-Targeted Therapy-Related Diarrhea in Patients With Hepatocellular Carcinoma Based on TCM Constitutional Types: A Prospective Cohort Study

for Liver Cancer

Sponsor: Affiliated Hospital of Chengde Medical University

Sex: All·Age: 18+

Code: NCT07741903

Phase 2 Trial Of S-531011 With RadScopal In Previously Treated Metastatic Colorectal Cancer

for Phase II

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT07720115·Phase 2

Outside the Cage (OTC) Robotic Esophagectomy

for Esophageal Cancer

Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)

Sex: All·Age: 18+

Code: NCT06735638·Phase 1

Magnetic Sentinel Lymph Node Mapping in Gastric Cancer

for Gastric Adenocarcinoma

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT05038098·Phase 1

Reducing Neoplasia Recurrence After Non-thermal Endoscopic Resection of Large Colorectal Polyps

for Colorectal Cancer

Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)

Sex: All·Age: 18+

Code: NCT07242820

Increasing CRC Screening in Community Health Centers Through Mobile Messaging Optimization

for Colorectal Cancer

4 sites incl. Boston

Sponsor: University of Colorado, Denver

Sex: All·Age: 45 - 75·Accepts healthy volunteers

Code: NCT07569250

GutCheck: Optimization of a Personalized Mobile Health App for Survivors of Gastrointestinal Cancer

for Gastrointestinal

Sponsor: Masonic Cancer Center, University of Minnesota

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07661017

Novel Couple-Based Mindfulness Intervention for Metastatic Colorectal Cancer

for Colorectal Cancer

1 site in Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT07759921

Apply to this trial

Clinical Efficacy of Adebrelimab With or Without Apatinib Mesilate and SOX Neoadjuvant Therapy in Locally Advanced Gastric Cancer

for Gastric Cancer

Sponsor: Fujian Medical University

Sex: All·Age: 18 - 75

Code: NCT07314203·Phase 3

Testing the Effects of Exercise on Colorectal Cancer Development After Treatment With Pelvic Radiation Therapy for Prostate Cancer

for Colon Polyp

2 sites incl. Duarte

Sponsor: City of Hope Medical Center

Sex: Male·Age: 40 - 80

Code: NCT07790718

Apply to this trial

Oncolytic Virus Plus PD-1 Inhibitor to Patients With Advanced Pancreatic Cancer

for Pancreatic Cancer

Sponsor: Fudan University

Sex: All·Age: 18 - 80

Code: NCT06196671·Phase 2

Study Examining the Safety and Toxicity of Stereotactic Body Radiotherapy (SBRT) Followed by PCX12 Immunotherapy Delivered by Intratumoral Injection for the Treatment of Patients With Locally Advanced Pancreatic Adenocarcinoma (LAPC)

for Pancreatic Adenocarcinoma

1 site in Rochester

Sponsor: Haoming (Carl) Qiu

Sex: All·Age: 18+

Code: NCT06217666·Phase 1

Minimally Invasive Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Cancer, SOS5C Trial

for Barrett Esophagus

3 sites incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT07206589

A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation

for Ovarian Cancer

Sponsor: LG Chem

Sex: All·Age: 18+

Code: NCT07752875·Phase 1, Phase 2

Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates

for Rectal Adenocarcinoma

3 sites incl. Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 100

Code: NCT07292298·Phase 2

Apply to this trial

CPHARM - CRC Study

for Colorectal Cancer

Sponsor: Monash University Malaysia

Sex: All·Age: 50 - 75·Accepts healthy volunteers

Code: NCT07714291

IKS04 Regimen in Advanced Solid Tumors That Express CA242

for Colorectal Cancer

4 sites incl. Los Angeles

Sponsor: Iksuda Therapeutics Ltd.

Sex: All·Age: 18+

Code: NCT07738939·Phase 1

Tucatinib Continuation Study

for HER2-positive Breast Cancer

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07768358·Phase 4

A Trial of Pembrolizumab With Chemotherapy or Chemoradiotherapy in Participants From India With Different Types of Cancer (MK-3475-G44/KEYNOTE-G44)

for Neoplasm Malignant

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT07801027·Phase 4

Evaluation of the Administration of Artificial Nutrition by Feeding Jejunostomy During Neoadjuvant Treatment on Postoperative Morbidity in the Context of Esophageal or Stomach Cancer

for Esophageal Cancer

Sponsor: University Hospital, Bordeaux

Sex: All·Age: 18+

Code: NCT07584577

Apply to this trial

[18F]FTT Positron Emission Tomography/Computed Tomography to Predict Treatment Response in Patients Scheduled to Receive Gemcitabine, Cisplatin, and Durvalumab for Newly Diagnosed Cholangiocarcinoma

for Cholangiocarcinoma

1 site in Seattle

Sponsor: University of Washington

Sex: All·Age: 18+

Code: NCT07673341·Phase 2

Spleen Preservation Versus Splenectomy in Left Pancreatectomy for Pancreatic Ductal Adenocarcinoma (SPLENDID)

for Pancreatic Cancer

Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Sex: All·Age: 18+

Code: NCT07799298

Total Neoadjuvant Therapy With Short Course Radiation Therapy in Gastric Cancer

for Gastric Cancer

4 sites incl. Los Angeles

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07101666·Phase 2

ctDNA-Informed Management of Early-Stage Rectal Cancer

for Rectal Adenocarcinoma

1 site in Sacramento

Sponsor: University of California, Davis

Sex: All·Age: 18+

Code: NCT07209215·Phase 2

Study to Evaluate the Diagnostic Performance of GEH300079 (68Ga) Injection PET/CT for Detection of PC in Patients With Colorectal, Gastric, Ovarian, or Pancreatic Cancers (PERISCOPE)

for Colorectal Cancer

1 site in Grand Rapids

Sponsor: GE Healthcare

Sex: All·Age: 18+

Code: NCT07219238·Phase 2, Phase 3

Apply to this trial

Transanal Irrigation for the Management of Early Low Anterior Resection Syndrome (LARS)

for Colorectal Cancer

1 site in Weston

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07219745

Endoscopic Management of Biliopancreatic Disease in the Lombardy Pancreas Units

for Pancreatic Cancer

Sponsor: IRCCS San Raffaele

Sex: All·Age: 18+

Code: NCT07418164

Combining DCSZ11 With Radiation and Chemotherapy as Neoadjuvant Treatment for pMMR Locally Advanced Rectal Cancer

for Rectal Cancer

1 site in Baltimore

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All·Age: 18+

Code: NCT07580339·Phase 2

Analysis of Breath Volatile Organic Compounds Using Mass Spectrometry

for Pancreas Cancer

1 site in Oklahoma City

Sponsor: University of Oklahoma

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07732686

Pancreatic Cancer Lifestyle Evolution And Resistance

for Pancreatic Cancer

Sponsor: IRCCS San Raffaele

Sex: All·Age: 18+

Code: NCT07794969

Molecularly Tailored Therapy in Advanced Pancreatic Cancer

for Pancreatic Cancer

Sponsor: Herlev Hospital

Sex: All·Age: 18+

Code: NCT07802418·Phase 2

Researching the Effect of Exercise on Cancer

for Breast Cancer

2 sites incl. Durate

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT04589468

Apply to this trial

Pharmacokinetics Study of Larotinib in Subjects With Impaired Hepatic Function

for Esophageal Cancer

Sponsor: Sunshine Lake Pharma Co., Ltd.

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT05048368·Phase 1

A Phase 1, Multicenter Imaging Study of LNTH-2403 in Participants With Locally Advanced or Metastatic Solid Tumors.

for Imaging

Sponsor: Radiopharm Theranostics, Ltd

Sex: All·Age: 18+

Code: NCT07272642·Phase 1

ctDNA and Organ Preservation/Pathologic CR in Rectal Cancer

for Rectal Cancer

2 sites incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05629442

Preventing Early-Onset Colorectal Cancer in the VA

for Colorectal Neoplasms

1 site in New York

Sponsor: VA Office of Research and Development

Sex: All·Age: 45 - 49·Accepts healthy volunteers

Code: NCT07071454

Yttrium-90 Radiation Segmentectomy for Hepatocellular Carcinoma

for Hepatocellular Carcinoma

1 site in San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 22+

Code: NCT07110233

Cemiplimab With Fianlimab for Resectable Non-Metastatic Colon Cancer

for Colon Cancer

Sponsor: John Strickler, M.D.

Sex: All·Age: 18+

Code: NCT07224022·Phase 2

Use of a Novel Camera to Check the Bowel After Polyp or Tumour Removal

for Bowel Cancer

Sponsor: University of Edinburgh

Sex: All·Age: 16+

Code: NCT07341126

Cemiplimab +/- Fianlimab Post Y90 Radioembolization in Patients With Hepatocellular Carcinoma

for Hepatocellular Carcinoma

1 site in Richmond

Sponsor: Virginia Commonwealth University

Sex: All·Age: 18+

Code: NCT07365839·Phase 1

A Study of Selective Internal Radiation Therapy for the Management of Chemotherapy-induced Thrombocytopenia With Splenomegaly in Adult Subjects With Gastrointestinal Cancer

for Gastrointestinal Cancer

Sponsor: Centre Georges Francois Leclerc

Sex: All·Age: 18+

Code: NCT07575854

Scheduled Meditation for Improving Postoperative Outcomes in Patients Undergoing Pancreatectomy

for Hepatocellular Carcinoma

1 site in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07608458

Concurrent Immunotherapy and Systemic Therapy With Stereotactic Body Radiation Therapy (SBRT) for Stage IV Cancers (COINSSS IV)

for Head and Neck Cancer

1 site in Lexington

Sponsor: Mark Bernard

Sex: All·Age: 18 - 99

Code: NCT07770100·Phase 2

Wearable-Supported Prehabilitation and Rehabilitation for Patients Undergoing Surgery for Pancreatic Cancer

for Pancreatic Cancer

Sponsor: Manchester University NHS Foundation Trust

Sex: All·Age: 18+

Code: NCT07772258

Zanidatamab Outcomes and Lived Experiences in Advanced HER2+ GEA

for Esophageal Cancer

2 sites incl. Orange

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07780968

A Non-inferiority Study of Indocyanine Green-guided Sentinel Lymph Node Mapping Versus Conventional Lymph Node Dissection in Esophageal Cancer

for Esophageal Cancer

Sponsor: Fujian Medical University Union Hospital

Sex: All·Age: 18 - 75

Code: NCT07788001·Phase 3

Radical Surgery Versus Non-Surgery in Gastric Cancer Patients With Peritoneal Metastasis After Successful Conversion Therapy

for Gastric Cancer

Sponsor: Hua Huang, MD, PhD

Sex: All·Age: 18 - 70

Code: NCT07789184·Phase 3

Evaluation of Versatile Intelligent Staining Technology (VIST) and Spectral Flexible Imaging (SFI) for Detection and Optical Characterization of Colorectal Lesions: A Prospective Randomized Controlled Study

for Colorectal Neoplasms

Sponsor: Alexandre Vontobel Padoin

Sex: All·Age: 18+

Code: NCT07797361

External Beam Radiotherapy Combined With Endorectal High-dose-rate Brachytherapy in Elderly and Frail Patients With Rectal Cancer

for Rectal Cancer

Sponsor: University Hospital of Cologne

Sex: All·Age: 70+

Code: NCT06729645

Colorectal Cancer Screening in the Homeless

for Colorectal Cancer

1 site in Washington D.C.

Sponsor: George Washington University

Sex: All·Age: 45 - 75

Code: NCT07220018

Chemotherapy With or Without IMD10 (Focused Ultrasound) in the Treatment of Borderline Resectable or Locally Advanced Pancreatic Cancer

for Pancreatic Cancer

3 sites incl. Boston

Sponsor: IMGT Co., Ltd.

Sex: All·Age: 18 - 85

Code: NCT07325214

SURGIMEDIA: Utilization of Multimedia for Enhanced Surgical Consent

for Pancreas Cancer

1 site in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07494994

A Phase 1a/1b, First-Time-in-Human Study of CT-202, a Nectin-4 Directed Bispecific Antibody, in Participants With Recurring Triple Negative Breast, Colorectal, Urothelial Cancers

for Triple Negative Breast Cancer (TNBC)

Sponsor: Context Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT07545122·Phase 1

Apply to this trial

GI-05: The Impact of Olanzapine Among Patients Receiving Neoadjuvant Chemotherapy for Gastric Cancer

for Gastric Adenocarcinoma

1 site in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT07581405·Phase 2

Nutritional Supplementation to Improve Colorectal Cancer Surgery

for Colorectal Cancer

Sponsor: Istituto Clinico Humanitas

Sex: All·Age: 18+

Code: NCT07599501

Upfront Chemotherapy With Radiation Therapy (CRT) Followed by Chemotherapy in Localized Esophageal Adenocarcinoma

for Esophageal Adenocarcinoma

1 site in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07603375·Phase 2

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GI oncology clinical trials — common questions

Are gi oncology clinical trials free to join?

Yes. Participating in a gi oncology clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a gi oncology clinical trial?

Each gi oncology study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a gi oncology trial near me?

Use the location controls above. We'll show recruiting gi oncology trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many gi oncology trials are recruiting right now?

We're currently tracking roughly 1008 recruiting gi oncology trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

GI oncology trials by city

Los Angeles, CA Boston, MA Duarte, CA Birmingham, AL Orange, CA San Francisco, CA Aurora, CO Chicago, IL Denver, CO Tampa, FL Cleveland, OH Miami, FL

Conditions in this area

Colorectal cancer Metastatic colorectal cancer Colon cancer Rectal cancer Pancreatic cancer Gastric cancer Esophageal cancer Gastroesophageal junction cancer Liver cancer Biliary tract cancer Gastrointestinal cancer