The Effect of GLP-1 on Postprandial Glucagon Secretion Independent of The Gastric Emptying Rate

Sponsor
Hvidovre University Hospital
Study ID
NCT02584582
Phase
PHASE2/PHASE3
Status
Unknown

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Liraglutide — DRUG
  • Exenatide — DRUG
  • Liquid meal test — PROCEDURE
  • No drug (Baseline day) — OTHER

Study Details

Aim: To investigate the glucagonostatic effect of glucagon-like peptide-1 (GLP-1) independent of the gastric emptying rate.

Key Dates

Start date
Jul 31, 2015
Status verified
Oct 2015
Primary completion
Nov 30, 2015

Study Design

Enrollment
10 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: Liraglutide + Liquid meal test
    Liraglutide 1.2 mg once daily for 14 days (0.6 mg/day for one week, escalated to 1.2 mg/day after one week)
  • Experimental: Exenatide + Liquid meal test
    Exenatide 10 mcg twice daily for 14 days (5 mcg twice daily for one week, escalated to 10 mcg twice daily after one week)
  • Other: Baseline + Liquid meal test
    Baseline day with no additional medication

Primary Outcome Measure

Glucagon concentration (postprandial) [ Time Frame: 4 hours ]

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