An Investigational Immuno-therapy Study of Experimental Medication BMS-986156, Given by Itself or in Combination With Nivolumab in Patients With Solid Cancers or Cancers That Have Spread.

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
Bristol-Myers Squibb
Study ID
NCT02598960
Phase
PHASE1/PHASE2
Status
Completed

Conditions

  • Solid Tumors

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

The purpose of this study is to evaluate the safety and tumor-shrinking ability of experimental medication BMS-986156, when given by itself or in combination with nivolumab in patients with solid cancers that are advanced or cancers that have spread.

Key Dates

Start date
Oct 14, 2015
Status verified
Feb 2023
Primary completion
Dec 16, 2019
Completion
Dec 16, 2019

Study Design

Enrollment
295 participants (actual)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: BMS-986156: Dose Escalation
  • Experimental: BMS-986156 + nivolumab (nivo): Dose Escalation
  • Experimental: BMS-986156: Dose Expansion
  • Experimental: BMS-986156 + nivolumab (nivo): Dose Expansion
  • Experimental: BMS986156 + Nivo: Cohort Expansion

Primary Outcome Measure

Number of Participants With All Cause Adverse Events (AEs), Serious Adverse Events, AEs Leading to Discontinuation and Deaths [ Time Frame: From first treatment to 100 days post last dose. Approximately 29 months ]

Locations (7)

FacilityCityStateZIPSite coordinators
University Of Alabama At BirminghamBirminghamAlabama35294-3300-
UCSD Moores Cancer CenterLa JollaCalifornia92093-0698-
Emory UniversityAtlantaGeorgia30322-
The Ohio State UniversityColumbusOhio43210-
Providence Portland Medical CenterPortlandOregon97213-
Thomas Jefferson University HospitalPhiladelphiaPennsylvania19107-
The West Clinic, P.C.GermantownTennessee38138-

Find similar trials in Birmingham, AL

By research site
University Of Alabama At Birmingham· Birmingham, ALUCSD Moores Cancer Center· La Jolla, CAEmory University· Atlanta, GAThe Ohio State University· Columbus, OHProvidence Portland Medical Center· Portland, ORThomas Jefferson University Hospital· Philadelphia, PA

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