Combination Therapy With Entinostat and Pembrolizumab in Relapsed and Refractory Lymphomas

Part of paid clinical trials in Evanston, Illinois.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT03179930
Phase
PHASE2
Status
Active Not Recruiting

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Entinostat — DRUG
    All patients will receive entinostat 5-7 mg PO as per the dosing regimen at the on D1, D8, and D15
  • Pembrolizumab — DRUG
    pembrolizumab 200 mg IV on D1

Study Details

The purpose of this study is to test any good and bad effects of the study drugs called Pembrolizumab and Entinostat when used in combination to treat lymphoma. This combination could shrink the lymphoma but it could also cause side effects. Researchers also hope to learn whether adding entinostat to pembrolizumab can be more effective for patients with lymphoma than either drug alone.

Key Dates

Start date
Jun 7, 2017
Status verified
Jul 2025
Primary completion
Jun 30, 2026
Completion
Jun 30, 2026

Study Design

Enrollment
47 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Entinostat and Pembrolizumab
    patients will be assigned to receive therapy with entinostat given by mouth once weekly and pembrolizumab given intravenously every 3 weeks

Primary Outcome Measure

Response using the 2014 Lugano Classification [ Time Frame: 2 years ]

Locations (9)

FacilityCityStateZIPSite coordinators
Northwestern University (Data Collection Only)EvanstonIllinois60208-
Memorial Sloan Kettering Basking RidgeBasking RidgeNew Jersey07920-
Memorial Sloan Kettering MonmouthMiddletownNew Jersey07748-
Memorial Sloan Kettering BergenMontvaleNew Jersey07645-
Roswell Park Cancer Institute (Data Collection Only)BuffaloNew York14263-0001-
Memorial Sloan Kettering CommackCommackNew York11725-
Memorial Sloan Kettering WestchesterHarrisonNew York10604-
Memorial Sloan Kettering Cancer CenterNew YorkNew York10065-
Memorial Sloan Kettering NassauUniondaleNew York11553-

Find similar trials in Evanston, IL

By research site
Northwestern University (Data Collection Only)· Evanston, ILMemorial Sloan Kettering Basking Ridge· Basking Ridge, NJMemorial Sloan Kettering Monmouth· Middletown, NJMemorial Sloan Kettering Bergen· Montvale, NJRoswell Park Cancer Institute (Data Collection Only)· Buffalo, NYMemorial Sloan Kettering Commack· Commack, NY

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