Rucaparib in Patients With Locally Advanced or Metastatic Urothelial Carcinoma

Part of paid clinical trials in Scottsdale, Arizona.

Sponsor
pharmaand GmbH
Study ID
NCT03397394
Phase
PHASE2
Status
Terminated

Conditions

  • Bladder Cancer
  • Metastatic Urothelial Carcinoma
  • Muscle Invasive Bladder Cancer
  • Renal Pelvis Carcinoma
  • Ureter Carcinoma
  • Urethra Carcinoma
  • Urinary Bladder Carcinoma
  • Urothelial Carcinoma

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Rucaparib — DRUG
    Rucaparib will be administered daily.

Study Details

The purpose of the ATLAS study is to determine how patients with locally advanced unresectable or metastatic urothelial carcinoma respond to treatment with rucaparib.

Key Dates

Start date
Jun 1, 2018
Status verified
Jun 2023
Primary completion
Dec 12, 2019
Completion
Jan 15, 2020

Study Design

Enrollment
97 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Rucaparib
    Oral rucaparib (monotherapy)

Primary Outcome Measure

Objective Response Rate (ORR) Per RECIST Version 1.1 [ Time Frame: Time from first dose to date of progression, up to approximately 19 months ]

Locations (41)

FacilityCityStateZIPSite coordinators
Pinnacle Oncology, Honor HealthScottsdaleArizona85258-
University of California San Diego (UCSD), Moores Cancer CenterLa JollaCalifornia92093-
University of California, Los Angeles (UCLA)Los AngelesCalifornia90095-
Universityof California, IrvineOrangeCalifornia92868-
Saint John's Health Center - John Wayne Cancer Institute (JWCI)Santa MonicaCalifornia90404-
Stanford University School of MedicineStanfordCalifornia94304-
Hartford Health Care Cancer InstituteHartfordConnecticut06102-
Eastern Connecticut Hematology & Oncology Associates (ECHO)NorwichConnecticut06360-
Medstar Georgetown University Medical CenterWashington D.C.District of Columbia20007-
Miami Cancer Institute, Baptist Health South FloridaMiamiFlorida33176-
Northwestern University, ChicagoChicagoIllinois60611-
Indiana University - Melvin and Bren Simon Cancer Center (IUSCC)IndianapolisIndiana46202-
The University of Iowa and Holden Comprehensive Cancer CenterIowa CityIowa52242-
Norton Cancer CenterLouisvilleKentucky40207-
Ochsner Cancer InstituteNew OrleansLouisiana70121-
University of Maryland, Marlene and Stewart Greenebaum Cancer CenterBaltimoreMaryland21201-
University of MichiganAnn ArborMichigan48109-
Minnesota Oncology Hematology P.A. (USO - US Oncology)MinneapolisMinnesota55404-
Comprehensive Cancer Centers of Nevada (CCCN)Las VegasNevada89169-
John Theurer Cancer Center at Hackensack University Medical CenterHackensackNew Jersey07601-
University of New Mexico UNM Cancer Research and Treatment CenterAlbuquerqueNew Mexico87102-
New York Oncology Hematology, P.C. (USO - US Oncology)AlbanyNew York12208-
Roswell Park Cancer InstituteBuffaloNew York14263-
Memorial Sloan Kettering Cancer CenterNew YorkNew York10065-
New York - Presbyterian Hospital-Weill Cornell Medical CenterNew YorkNew York10021-
Duke University, Duke Cancer InstituteDurhamNorth Carolina27710-
Stephenson Cancer CenterOklahoma CityOklahoma73104-
Northwest Cancer Specialists P.C. (USO - US Oncology)PortlandOregon97062-
Oregon Health and Science UniversityPortlandOregon97239-
Providence Portland Medical CenterPortlandOregon97213-
Lehigh Valley Health NetworkAllentownPennsylvania18103-
Penn State Hershey Medical CenterHersheyPennsylvania17033-
Atlantic Urology ClinicsMyrtle BeachSouth Carolina29572-
University Oncology & HematologyChattanoogaTennessee37403-
Urology AssociatesNashvilleTennessee37209-
Texas Oncology PA (USO - US Oncology)DallasTexas76201-
University of Texas, UT Health Science CenterHoustonTexas77030-
University of Utah, Huntsman Cancer InstituteSalt Lake CityUtah84112-
University of Virginia, Emily Couric Clinical CenterCharlottesvilleVirginia22908-
University of Washington / Seattle Cancer Care AllianceSeattleWashington98109-
Froedtert & Medical College of WisconsinMilwaukeeWisconsin53226-

Find similar trials in Scottsdale, AZ

By condition
Bladder cancer
By specialty
OncologyUrology
By research site
Pinnacle Oncology, Honor Health· Scottsdale, AZUniversity of California San Diego (UCSD), Moores Cancer Center· La Jolla, CAUniversity of California, Los Angeles (UCLA)· Los Angeles, CAUniversityof California, Irvine· Orange, CASaint John's Health Center - John Wayne Cancer Institute (JWCI)· Santa Monica, CAStanford University School of Medicine· Stanford, CA

Related Studies