Incidence of HANA Conditions in HIV-infected Individuals

Conditions

• HIV
• Liver Fibroses
• Metabolic Syndrome
• Osteopenia
• Osteoporosis
• Renal Impairment
• Vitamin D Deficiency

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Study Details

With the availability of effective anti-retroviral therapy, HIV-infected individuals are expected not to die of AIDS and have longer life expectancy. But at the same time, HIV-associated non-AIDS (HANA) conditions are becoming more important in their clinical management. It is currently uncertain whether patients started on different anti-retroviral regimens will have different incidence of HANA conditions. This study aims to evaluate the incidence of various HANA conditions in a cohort of newly diagnosed HIV-infected individuals in Hong Kong initiating anti-retroviral treatment. The incidence of various HANA conditions will be evaluated for those receiving INSTI versus other non-INSTI-based regimens. The HANA conditions evaluated will include 1. Hypertension 2. Diabetes and insulin resistance 3. Dyslipidemia 4. Lipodystrophy 5. Metabolic syndrome 6. Osteopenia and osteoporosis 7. Vitamin D deficiency 8. Renal impairment and kidney tubular dysfunction and 9. Liver fibrosis. Patients will be assessed prior to initiation of anti-retroviral therapy, and 48 weeks and 96 weeks after initiation of treatment. The incidence of development of each HANA condition will be determined and compared between those initiated different anti-retroviral regimens.

Key Dates

First listed

Mar 30, 2018

Start date

Apr 6, 2018

Status verified

Nov 2025

Primary completion

Mar 31, 2024

Completion

Sep 30, 2024

Study Design

Enrollment

215 participants (actual)

Arms

• Arm: INSTI
  INSTI-containing ART regimens
• Arm: non-INSTI
  non-INSTI-containing ART regimens

Primary Outcome Measure

Prevalences of HIV-associated Non-AIDS Conditions (HANA) [ Time Frame: Baseline ]

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