Infectious disease Clinical Trials

Recruiting infectious disease studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat infectious disease. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting infectious disease studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting infectious disease trials

Within

Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans

for Opioid Use Disorder

1 site in Northport

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06766331

Healthy Choices to Reduce Stigma and Improve Self-Management of Alcohol and HIV Among Young Adults

for HIV

1 site in Tallahassee

Sponsor: Florida State University

Sex: All·Age: 18 - 29

Code: NCT07638618

Intervention to Reduce Implicit Bias in Pharmacies

for Bias, Implicit

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06487351

Same-Day Antiretroviral Therapy as a Behavioral Design Intervention to Reduce Stigma in Key Affected Populations

for Hiv

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT07053514

Scaling Up Implementation Strategies to Improve the DIAGNOSE and PREVENT Pillars for Young MSM in Florida

for Hiv

1 site in Tallahassee

Sponsor: Florida State University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06015581

PrEPwise Pilot Among Black Women in Eastern Virginia

for HIV Infections

1 site in Norfolk

Sponsor: Boston University

Sex: Female·Age: 18+

Code: NCT07398482

HIV Self-Testing and Long-Acting Injectables for HIV Treatment and Prevention Among Commercial Minibus Drivers (I-TEST LAIs) in Nigeria

for HIV

Sponsor: George Washington University

Sex: Male·Age: 18+·Accepts healthy volunteers

Code: NCT07000513·Phase 4

The Extended Study of Prevalence of Infection in Intensive Care IV

for Sepsis

Sponsor: Universidad de la Sabana

Sex: All·Age: 18+

Code: NCT07309549

Integrated Health Services (IHS): A Structural Intervention to Improve HIV/STI Screening and PrEP Navigation in Primary Care

for HIV

1 site in Ridgeland

Sponsor: My Brother's Keeper, Inc.

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07446764

Yuva Sath: A Peer-led Behavioral Intervention to Support Substance Use Treatment and HIV Prevention Among Young People Who Inject Drugs in India

for Hiv

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 29

Code: NCT06510192

A Social Network Approach to Improve HIV Prevention and Substance Use Treatment For People Who Use Drugs

for Substance Use

3 sites incl. Los Angeles

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT07409350

Safety and Efficacy of Low-dose Anticoagulation With Argatroban and Enoxaparin on ECMO

for Pneumonia

Sponsor: University Hospital Ostrava

Sex: All·Age: 18+

Code: NCT07499037·Phase 2

Leveraging Pharmacy Technicians to Advance the Reach of Modern Antiretroviral Therapy (PHARM ART) in Community Clinics

for HIV

Sponsor: University of Chicago

Sex: All·Age: 15+

Code: NCT07553949

Evaluation of the Safety and Efficacy of XoGlo Pro, a Placental Mesenchymal Stem Cell-derived Extracellular Vesicles in Treating COVID-19 Symptoms

for COVID-19

Sponsor: Kimera Labs Inc.

Sex: All·Age: 18+

Code: NCT07664696·Phase 1, Phase 2

Decision Support Tool to Integrate PrEP Into Emergency Departments

for HIV

2 sites incl. Washington D.C.

Sponsor: George Washington University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07279129·Phase 1

Biological Effects of Hemoadsorption in Septic Shock

for Septic Shock, Vasopressor Resistance

Sponsor: Miguel Sanchez Garcia

Sex: All·Age: 18+

Code: NCT07715110

Improving HIV Prevention and Substance Use Post-Sexual Assault Services

for HIV Infections

1 site in Houston

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 17 - 25

Code: NCT07225062

Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress

for Critical Illness

3 sites incl. Los Angeles

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07634419

Optimizing Implementation of Long Acting Injectable PrEP

for HIV Infections

Sponsor: University of Minnesota

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07649551

Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis

for Sepsis

1 site in Houston

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 18+

Code: NCT01315782

Implementation of PrEP Care Among Women in Family Planning Clinics

for PrEP Uptake

Sponsor: Rush University Medical Center

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT06335121

A Study to Evaluate the Safety and Antiviral Activity of Two Human Monoclonal Antibodies (VRC07-523LS and PGT121.414.LS) During Analytic Treatment Interruption in Participants Living With HIV Who Initiated ART During Acute/Early HIV-1 Infection

for HIV-1-infection

10 sites incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 70

Code: NCT06987318·Phase 1

HEME-25: Open-Label Feasibility Study of Elranatamab Utilized in Newly Diagnosed Plasmablastic Lymphoma With or Without HIV

for Plasmablastic Lymphoma

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT07647432·Phase 2, Phase 3

Fatigue in Long COVID

for Long COVID

Sponsor: McMaster University

Sex: All·Age: 18 - 65

Code: NCT07697261

Theoretically Informed Behavioral Intervention

for HIV

1 site in Orange

Sponsor: Yale University

Sex: Male·Age: 18+

Code: NCT06580184

Peer-led Community-based PrEP Delivery Among Youth in Brazil

for Pre-Exposure Prophylaxis (PrEP)

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 15 - 24·Accepts healthy volunteers

Code: NCT06661356

STeroids and Enhanced Spectrum Antibiotics for the Treatment of Patients in Africa With Refractory Sepsis

for Sepsis

Sponsor: University of Virginia

Sex: All·Age: 18+

Code: NCT07332325·Phase 3

Extended vs. Intermittent Beta-Lactam Infusion in ICU Sepsis

for Sepsis

Sponsor: Assiut University

Sex: All·Age: 18 - 65

Code: NCT07398703

Biomarkers for Post-treatment Control in HIV: International Study of the EU2Cure Research Consortium (Phase I)

for HIV

Sponsor: Erasmus Medical Center

Sex: All·Age: 16+·Accepts healthy volunteers

Code: NCT07692295

Ulinastatin on Systemic Immune-Inflammation in Patients With Complicated Intra-Abdominal Infection

for Complicated Intra-abdominal Infection (cIAI)

Sponsor: Fujian Medical University Union Hospital

Sex: All·Age: 18+

Code: NCT07672496

Digital Intervention Delivered Via Street Medicine to Increase HIV and Substance Use Care Among Survivors of Sex Trafficking

for Sex Trafficking

1 site in Providence

Sponsor: Lifespan

Sex: Female·Age: 18+

Code: NCT07699484·EARLY_Phase 1

Ketogenic Approach to Restore Muscle in Older Patients With Community-Acquired Pneumonia - KARMA-P Trial

for Pneumonia

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 55+

Code: NCT07308483

TelePharm PrEP/PEP

for HIV

Sponsor: Fred Hutchinson Cancer Center

Sex: All·Age: 15+·Accepts healthy volunteers

Code: NCT07561658

INTEGRATE-RX: Integrating Clinical Pharmacists in HIV Care to Mitigate Last-Mile Challenges and Reduce Cardiovascular Disease Burden

for HIV

Sponsor: Temple University

Sex: All·Age: 18 - 75

Code: NCT07711366

Paclitaxel and Pegylated Liposomal Doxorubicin for Treatment of HIV-related Kaposi Sarcoma

for Kaposi Sarcoma

Sponsor: AIDS Malignancy Consortium

Sex: All·Age: 18+

Code: NCT05411237·Phase 3

Developing an HIV Disclosure Intervention for Men in Uganda

for HIV Infections

Sponsor: Brigham and Women's Hospital

Sex: Male·Age: 18+·Accepts healthy volunteers

Code: NCT05771519

Confidential Care and Adolescent HIV Testing

for Hiv

Sponsor: Yale University

Sex: All·Age: 13 - 17

Code: NCT06279949

Development of a Multilevel HIV Prevention Intervention for the Emergency Department

for HIV

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06331767

Leveraging Video Logs as a Bridge to Pre-exposure Prophylaxis (PrEP) With Tailored Messaging to Black Women and Their Healthcare Providers in Texas.

for HIV Prevention

1 site in Galveston

Sponsor: The University of Texas Medical Branch, Galveston

Sex: Female·Age: 18 - 99·Accepts healthy volunteers

Code: NCT06864689·EARLY_Phase 1

HIV Testing in Community Health Center Dental Clinics

for HIV

4 sites incl. Boston

Sponsor: Boston University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07089849

Baricitinib Curative Repression of HIV-1

for HIV Infection

2 sites in Atlanta

Sponsor: Emory University

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT07209267·Phase 2

C11 ER176 PET in Evaluating Neuroinflammation in Patients With Post-COVID Syndrome

for COVID-19

1 site in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07527130

Evaluation of biomArkers for Quick SEpsis Diagnosis - ErASED Study

for Sepsis

Sponsor: Fondazione IRCCS Policlinico San Matteo di Pavia

Sex: All·Age: 18+

Code: NCT07655154

Liver Transplantation From Donors With HIV: Impact on Opportunistic Infections, Cancer, and Long-Term Outcomes (Expanding HOPE Liver)

for HIV

19 sites incl. Phoenix

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT07665372

Taurine Supplementation in Adolescents With Post-COVID Condition

for Long COVID

Sponsor: University of Alberta

Sex: All·Age: 10 - 17

Code: NCT07682402·Phase 1, Phase 2

Pharmacy-based Provision of Pre-exposure Prophylaxis (PrEP) for Adolescent Girls and Young Women in Tanzania

for HIV

Sponsor: Mzumbe University - Centre of Excellence in Health Monitoring and Evaluation

Sex: Female·Age: 18 - 24·Accepts healthy volunteers

Code: NCT07687888

Transcranial Direct Current Stimulation for Long COVID Brain Fog and Fatigue

for Long COVID

Sponsor: University of Las Palmas de Gran Canaria

Sex: All·Age: 18 - 70

Code: NCT07709234

Combating HIV Stigma in Healthcare Settings: A Standardized Patient Approach

for Hiv

1 site in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT06975176

Immunogenicity of MF59-adjuvanted Versus High-dose Influenza Vaccine in People With HIV: a Randomized Clinical Trial

for HIV

Sponsor: National Taiwan University Hospital

Sex: All·Age: 18+

Code: NCT07644546

Evaluating the Safety and Immunogenicity of Polyvalent DNA and Recombinant gp120 Protein HIV Vaccine (PDPHV) in Healthy, HIV-uninfected Adults

for HIV Prevention

1 site in Boston

Sponsor: Worcester HIV Vaccine

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07675629·Phase 2

Study of HIV-Exposed Pregnancies and Transplacental Antibody Delivery Following RSVpreF

for RSV Immunization

Sponsor: University of British Columbia

Sex: Female·Age: 19+

Code: NCT07693166·Phase 4

Monitoring of Septic Shock-induced Immunosuppression

for Sepsis

Sponsor: Hospices Civils de Lyon

Sex: All·Age: 18+

Code: NCT07698093

Evaluating the Healthy Families PrEP Program for Women at Risk for HIV

for HIV

Sponsor: Yale University

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT06746675

Integrating Supports to Promote PrEP for Black Adolescents Working With Apps- Alabama

for HIV

1 site in Birmingham

Sponsor: Emory University

Sex: All·Age: 14 - 21·Accepts healthy volunteers

Code: NCT06876324

Integrating U=U Into HIV Counseling in South Africa (INTUIT-2.0)

for HIV

Sponsor: Boston University

Sex: All·Age: 18+

Code: NCT07199634

Optimizing Medications and Lung Health in People With HIV Through Pharmacist-led Proactive E-Consults

for HIV

3 sites incl. Boise

Sponsor: Seattle Institute for Biomedical and Clinical Research

Sex: All·Age: 18+

Code: NCT07507435

Integrating Supports to Promote PrEP for Black Adolescents Working With Apps- Atlanta

for HIV Infections

1 site in Atlanta

Sponsor: Emory University

Sex: All·Age: 14 - 21·Accepts healthy volunteers

Code: NCT07535346

CBC Indices and Serum Lactate in Neonatal Sepsis

for Neonatal Sepsis

Sponsor: Assiut University

Sex: All·Age: 0 Days - 28 Days

Code: NCT07663084

PEP/PrEP Via Pharmacist-Prescribing Implementation (PEPPI)

for HIV Prevention

1 site in Del Mar

Sponsor: EMPOWERX INC

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07683117

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Development of Context-Adapted Quality Indicators for Early Sepsis Care in Sub-Saharan Africa - A Modified Delphi Consensus Procedure

for Sepsis

Sponsor: Charite University, Berlin, Germany

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07711535

Infectious disease clinical trials — common questions

Are infectious disease clinical trials free to join?

Yes. Participating in a infectious disease clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a infectious disease clinical trial?

Each infectious disease study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a infectious disease trial near me?

Use the location controls above. We'll show recruiting infectious disease trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many infectious disease trials are recruiting right now?

We're currently tracking roughly 469 recruiting infectious disease trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Infectious disease trials by city

San Francisco, CA Boston, MA Birmingham, AL Chicago, IL Miami, FL Los Angeles, CA San Diego, CA Gainesville, FL Indianapolis, IN Seattle, WA Aurora, CO Columbus, OH

Conditions in this area

HIV COVID-19 / long COVID Influenza Pneumonia Sepsis Infections (general)