A Study of CC-95251, a Monoclonal Antibody Directed Against SIRPα, in Participants With Advanced Solid and Hematologic Cancers

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
Celgene
Study ID
NCT03783403
Phase
PHASE1
Status
Terminated

Conditions

  • Neoplasms

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • CC-95251 — DRUG
    Specified dose on specified days
  • Rituximab — DRUG
    Specified dose on specified days
  • Cetuximab — DRUG
    Specified dose on specified days

Study Details

The purpose of this study is to evaluate the safety, tolerability, and preliminary clinical activity of CC-95251 as a single agent and in combination with cetuximab and rituximab in participants with advanced solid and hematologic cancers.

Key Dates

Start date
Mar 1, 2019
Status verified
Sep 2024
Primary completion
Aug 5, 2024
Completion
Aug 5, 2024

Study Design

Enrollment
206 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: CC-95251
  • Experimental: CC-95251 in combination with rituximab
  • Experimental: CC-95251 in combination with cetuximab

Primary Outcome Measure

Non-Tolerated Dose (NTD): A dose that causes unacceptable side effects [ Time Frame: 18 months ]

Locations (13)

FacilityCityStateZIPSite coordinators
Local Institution - 105BirminghamAlabama35294-
Local Institution - 101ScottsdaleArizona85258-
Local Institution - 112SacramentoCalifornia95817-
Rocky Mountain Cancer Centers, LLP [Aurora-COAU]AuroraColorado80012-
Local Institution - 115St LouisMissouri63110-
Local Institution - 110New YorkNew York10016-
Local Institution - 109CharlotteNorth Carolina28204-
Local Institution - 106Oklahoma CityOklahoma73104-
Local Institution - 113PortlandOregon97213-
Local Institution - 107PittsburghPennsylvania15232-
Local Institution - 102NashvilleTennessee37203-1625-
Local Institution - 108HoustonTexas77030-
Local Institution - 103San AntonioTexas78229-

Find similar trials in Birmingham, AL

By research site
Local Institution - 105· Birmingham, ALLocal Institution - 101· Scottsdale, AZLocal Institution - 112· Sacramento, CARocky Mountain Cancer Centers, LLP [Aurora-COAU]· Aurora, COLocal Institution - 115· St Louis, MOLocal Institution - 110· New York, NY

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