Study of Personalized Tumor Vaccines (PCVs) and a PD-L1 Blocker in Patients With Pancreatic Cancer That Can be Treated With Surgery

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT04161755
Phase
PHASE1
Status
Active Not Recruiting

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Atezolizumab — DRUG
    Atezolizumab will be administered 6 weeks post-tumor resection (+/- 2 weeks)
  • RO7198457 — BIOLOGICAL
    RO7198457 will be administered 9 weeks post-tumor resection (+/- 2 weeks)
  • mFOLFIRINOX — DRUG
    mFOLFIRINOX regimen will be administered 21 weeks post-tumor resection (+/- 2 weeks)

Study Details

The purpose of this study is to evaluate the safety or treating pancreatic cancer with surgery to remove cancerour tissue, followed by atezolizumab, followed by a personalized cancer vaccine (PCV), and then with chemotherapy.

Key Dates

Start date
Dec 13, 2019
Status verified
Jan 2026
Primary completion
Nov 11, 2026
Completion
Nov 11, 2026

Study Design

Enrollment
29 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Pancreatic Cancer
    Radiologically resectable primary pancreatic tumors

Primary Outcome Measure

Drug related toxicity [ Time Frame: 2 years ]

Locations (7)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering Basking Ridge (All Protocol Activities)Basking RidgeNew Jersey07920-
Memorial Sloan Kettering Monmouth (All Protocol Activities)MiddletownNew Jersey07748-
Memorial Sloan Kettering Bergen (All Protocol Activities)MontvaleNew Jersey07645-
Memorial Sloan Kettering Cancer Center @ Commack (All Protocol Activities)CommackNew York11725-
Memorial Sloan Kettering Westchester (All Protocol Activities)HarrisonNew York10604-
Memorial Sloan Kettering Cancer CenterNew YorkNew York10065-
Memorial Sloan Kettering Nassau (All Protocol Activities)Rockville CentreNew York11570-

Find similar trials in Basking Ridge, NJ

By condition
Pancreatic cancer
By specialty
OncologyGI oncology
By research site
Memorial Sloan Kettering Basking Ridge (All Protocol Activities)· Basking Ridge, NJMemorial Sloan Kettering Monmouth (All Protocol Activities)· Middletown, NJMemorial Sloan Kettering Bergen (All Protocol Activities)· Montvale, NJMemorial Sloan Kettering Cancer Center @ Commack (All Protocol Activities)· Commack, NYMemorial Sloan Kettering Westchester (All Protocol Activities)· Harrison, NYMemorial Sloan Kettering Cancer Center· New York, NY

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