Hypertonic Saline Nasal Irrigation and Gargling in Suspected or Confirmed COVID-19 (ELVIS COVID-19)

Sponsor
University of Edinburgh
Study ID
NCT04382131
Status
Terminated

Conditions

  • COVID
  • Upper Respiratory Tract Infections
  • Virus
  • Virus Diseases
  • Virus Shedding

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • NaCl Solution — OTHER
    NaCl Solution prepared by participants at home using water and salt

Study Details

ELVIS COVID-19 is a pragmatic web-based Bayesian adaptive randomised controlled, parallel group trial of hypertonic saline nasal irrigation and gargling (HSNIG) compared to standard care in participants with clinically suspected or confirmed COVID-19 being managed at home.

Key Dates

Start date
Jun 23, 2020
Status verified
Mar 2026
Primary completion
Oct 31, 2020
Completion
Oct 31, 2020

Study Design

Enrollment
16 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Hypertonic saline nasal irrigation and gargling
    Participants in the intervention arm will be asked to perform hypertonic saline nasal irrigation and gargling up to 12 times daily for a maximum of 14 days or until they report that they feel well.
  • No Intervention: Standard Care
    Participants in the control arm will be given standard NHS guidance for the management of their symptoms and household hygiene.

Primary Outcome Measure

Time to Resolution of Symptoms as Defined by the Single Question 'How Unwell do You Feel Today'. [ Time Frame: Maximum of 14 days ]

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