Heterozygous Individuals for AGXT and Kidney Stones

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
University of Alabama at Birmingham
Study ID
NCT04430426
Status
Enrolling By Invitation

Conditions

  • Kidney Stone
  • Urolithiasis, Calcium Oxalate

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Controlled Diet — OTHER
    Participants will consume a controlled low oxalate diet for five days.

Study Details

This study seeks to examine the effects of a heterozygous mutation of the AGXT gene in a stone forming population on endogenous oxalate production. Participants will consume a controlled low-oxalate diet and provide blood and urine samples to measure the amount of oxalate in their bodies.

Key Dates

First listed
Jun 12, 2020
Start date
Jul 1, 2027
Status verified
Jul 2026
Primary completion
Aug 1, 2031
Completion
Aug 1, 2032

Study Design

Enrollment
4 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER

Arms

  • Experimental: Controlled Dietary Study
    Participants will consume the controlled diet for five days. Participants will provide urine and blood samples to measure oxalate levels.

Primary Outcome Measure

Urinary Oxalate Excretion [ Time Frame: Baseline through Day 4 ]

Locations (1)

FacilityCityStateZIPSite coordinators
University of Alabama at BirminghamBirminghamAlabama35233-

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By research site
University of Alabama at Birmingham· Birmingham, AL

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