THC + CBD and Memory Study

Sponsor
Hartford Hospital
Study ID
NCT04855526
Phase
EARLY_PHASE1
Status
Not Yet Recruiting

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Conditions

  • Cannabis Intoxication
  • Cannabis Use
  • Marijuana Use

Eligibility Criteria

Sex
ALL
Age
18 Years - 40 Years
Healthy Volunteers
Accepted

Interventions

  • High THC/No CBD Marihuana — DRUG
    high THC (65 mg THC) and no CBD (0 mg CBD)
  • High THC/High CBD Marihuana — DRUG
    high THC (65 mg THC) and high CBD (50 mg CBD)
  • No THC/No CBD Marihuana — DRUG
    no THC (0 mg THC) and no CBD (0 mg CBD); placebo drug

Study Details

Memory deficits are one of the most consistently observed cognitive effects of marijuana use. There is evidence that some decrements attributable to the primary psychoactive ingredient, delta-9-tetrahydrocannabinol (THC), may be attenuated by cannabidiol (CBD). This study will help us learn more about the relationship between THC and CBD consumption with memory processes. A combination of MRI and neuropsychological tests (which are computer and paper/pencil tasks) will be used to measure the neurocognitive and behavioral impacts of THC and CBD use.

Key Dates

First listed
Apr 22, 2021
Start date
Dec 1, 2025
Status verified
Mar 2025
Primary completion
Dec 30, 2026
Completion
Dec 30, 2026

Study Design

Enrollment
9 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER

Arms

  • Experimental: Occasional Users - High THC and High CBD Dose
    People who smoke marijuana occasionally will be given a dose of high THC high CBD marijuana at the study visit
  • Experimental: Occasional Users - High THC and No CBD Dose
    People who smoke marijuana occasionally will be given a dose of high THC and no CBD marijuana at the study visit
  • Experimental: Occasional Users - No THC and No CBD Dose
    People who smoke marijuana occasionally will be given a dose of marijuana that contains no THC or CBD

Primary Outcome Measure

fMRI response [ Time Frame: approximately 1 hour following drug administration ]

Central Contacts

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