Melanin and Dermal Uptake of Thirdhand Cigarette Smoke

Part of paid clinical trials in San Francisco, California.

Sponsor
University of California, San Francisco
Study ID
NCT06020248
Status
Recruiting
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Conditions

  • Healthy

Eligibility Criteria

Sex
ALL
Age
18 Years - 50 Years
Healthy Volunteers
Accepted

Interventions

  • Wear clothing that has been exposed to cigarette smoke for 3 hours. — OTHER
    Cotton clothing is exposed to smoke from Marlboro Red (hard pack) cigarettes at 1-1.2 mg/m3 repeatedly, until total exposure equals 3 grams total particulate material. When tested after exposure, the clothing typically contained 59.15 +/- 18 µg nicotine and 42 +/- 24 ng NNK per gram. The mass of the clothing varies by size, but the average combination of pants and shirt contains 32 mgs nicotine and 23 µg NNK.

Study Details

This is a pilot study of the effects of dermal melanin on dermal uptake and retention of nicotine. The initial hypothesis is that higher levels of dermal melanin will correlate with lower uptake and longer retention of nicotine in the skin and body.

Key Dates

Start date
Sep 1, 2023
Status verified
Jun 2026
Primary completion
Nov 30, 2026
Completion
Nov 30, 2026

Study Design

Enrollment
60 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Low melanin
    Individuals with skin reflectance scores below 150 using the Mexameter 18 instrument.
  • Experimental: High melanin
    Individuals with skin reflectance scores above 249 using the Mexameter 18 instrument

Primary Outcome Measure

Change in blood concentrations of nicotine [ Time Frame: Baseline and 3 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Zuckerberg San Francisco General HospitalSan FranciscoCalifornia94110
Suzyann Schick, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
Zuckerberg San Francisco General Hospital· San Francisco, CA

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