A US Study to Evaluate Transarterial Radioembolization (TARE) in Combination With Durvalumab and Bevacizumab Therapy in People With Unresectable Hepatocellular Carcinoma Amenable to TARE

Part of paid clinical trials in Aurora, Colorado.

Sponsor
AstraZeneca
Study ID
NCT06040099
Phase
PHASE2
Status
Active Not Recruiting

Conditions

  • Hepatocellular Carcinoma (HCC)

Eligibility Criteria

Sex
ALL
Age
18 Years - 130 Years
Healthy Volunteers
Not accepted

Interventions

  • Durvalumab — DRUG
    Durvalumab IV (intravenous)
  • Bevacizumab — DRUG
    Bevacizumab IV (intravenous)
  • Transarterial Radioembolization (TARE) — PROCEDURE
    Yttrium 90 glass microspheres will be administered

Study Details

The purpose of this study is to measure the efficacy and safety of durvalumab intravenous (IV) solution plus bevacizumab IV solution after transarterial radioembolization (Yttrium 90 glass microspheres TARE) in participants with unresectable hepatocellular carcinoma (HCC) amenable to embolization.

Key Dates

Start date
Feb 13, 2024
Status verified
Mar 2026
Primary completion
Jul 1, 2026
Completion
Jul 1, 2026

Study Design

Enrollment
58 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Yttrium 90 glass microspheres TARE in combination with Durvalumab and Bevacizumab
    Participants will undergo Yttrium 90 glass microspheres TARE according to the dosimetry recommendation.

Primary Outcome Measure

Progression Free Survival (PFS) [ Time Frame: From Day 1 until date of progressive disease or death [Approximately 3 years] ]

Locations (21)

FacilityCityStateZIPSite coordinators
Research SiteAuroraColorado80045-
Research SiteGainesvilleFlorida32608-
Research SiteOrlandoFlorida32804-
Research SiteAtlantaGeorgia30322-
Research SiteAtlantaGeorgia30342-
Research SiteChicagoIllinois60611-
Research SiteBostonMassachusetts02118-
Research SiteDetroitMichigan48201-
Research SiteSt LouisMissouri63110-
Research SiteTrentonNew Jersey08690-
Research SiteBuffaloNew York14263-
Research SiteNew YorkNew York10029-
Research SiteChapel HillNorth Carolina27599-
Research SiteColumbusOhio43210-
Research SitePortlandOregon97239-
Research SitePhiladelphiaPennsylvania19107-
Research SiteHoustonTexas77030-
Research SiteCharlottesvilleVirginia22908-
Research SiteSeattleWashington98195-
Research SiteMilwaukeeWisconsin53215-
Research SiteMilwaukeeWisconsin53226-

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Research Site· Aurora, COResearch Site· Gainesville, FLResearch Site· Orlando, FLResearch Site· Atlanta, GAResearch Site· Chicago, ILResearch Site· Boston, MA

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