A Study of Glofitamab and Lenalidomide in People With Mantle Cell Lymphoma

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT06192888
Phase
PHASE1
Status
Active Not Recruiting

Conditions

  • MCL
  • Mantle Cell Lymphoma

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Glofitamab — DRUG
    IV Glofitamab
  • Obinutuzumab — DRUG
    IV Obinutuzumab
  • Lenalidomide — DRUG
    Oral Lenalidomide

Study Details

The purpose of this study is to find out whether the combination of glofitamab and lenalidomide is an effective treatment for relapsed or refractory Mantle Cell Lymphoma

Key Dates

Start date
Jan 8, 2024
Status verified
Mar 2026
Primary completion
Jan 8, 2028
Completion
Jan 8, 2028

Study Design

Enrollment
39 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Participants with Mantle Cell Lymphoma
    Participants will be diagnosed with relapsed, refractory (R/R) mantle cell lymphoma (MCL) with prior BTK inhibitor (BTKi) failure

Primary Outcome Measure

Proportion of participants who successfully receive glofitamab [ Time Frame: 1 year ]

Locations (10)

FacilityCityStateZIPSite coordinators
Dana Farber Cancer Institute (Data Collection and Specimen Analysis)BostonMassachusetts02115-
Mayo Clinic (Data Collection Only)RochesterMinnesota55905-
Washington University (Data Collection Only)St LouisMissouri63110-
Memorial Sloan Kettering Cancer Center at Basking Ridge (Limited Protocol Activities)Basking RidgeNew Jersey07920-
Memorial Sloan Kettering Monmouth (Limited protocol activities)MiddletownNew Jersey07748-
Memorial Sloan Kettering Bergen (Limited Protocol Activities)MontvaleNew Jersey07645-
Memorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities)CommackNew York11725-
Memorial Sloan Kettering Westchester (Limited protocol activities)HarrisonNew York10604-
Memorial Sloan Kettering Cancer Center (All Protocol Activities)New YorkNew York10065-
Memorial Sloan Kettering Nassau (All protocol activities)Rockville CentreNew York11553-

Find similar trials in Boston, MA

By research site
Dana Farber Cancer Institute (Data Collection and Specimen Analysis)· Boston, MAMayo Clinic (Data Collection Only)· Rochester, MNWashington University (Data Collection Only)· St Louis, MOMemorial Sloan Kettering Cancer Center at Basking Ridge (Limited Protocol Activities)· Basking Ridge, NJMemorial Sloan Kettering Monmouth (Limited protocol activities)· Middletown, NJMemorial Sloan Kettering Bergen (Limited Protocol Activities)· Montvale, NJ

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