Reducing Heart Failure Risk in Late-Life With Physical Activity

Sponsor
Brigham and Women's Hospital
Study ID
NCT06247774
Status
Not Yet Recruiting

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Conditions

  • Cardiac Rehabilitation
  • Exercise Training
  • Hypertension
  • Proteomics

Eligibility Criteria

Sex
ALL
Age
65 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Cardiac Rehabilitation — BEHAVIORAL
    Participation in a 12-week cardiac rehabilitation program
  • Attention Control — BEHAVIORAL
    Participants will receive regular phone calls in place of cardiac rehabilitation visits

Study Details

The goal of this clinical trial is to learn about the molecular pathways associated with the benefit of a regular exercise program in patients with high blood pressure and who don't already participate in regular exercise. The main question it aims to answer is to identify protein signatures associated with the benefits of a cardiac rehabilitation exercise program. The trial will enroll 42 participants, who will be randomized to a 12 week cardiac rehabilitation exercise program versus control arm and asked to participate in the following at the beginning and end of study: * Cardiopulmonary exercise test (CPET) * Echocardiogram * Physical function test * 6-minute walk test * Hand grip strength * Quality of life questionnaire * Blood draws Researchers will compare results between those who do and don't participate in the exercise program.

Key Dates

First listed
Feb 8, 2024
Start date
Jun 30, 2026
Status verified
Nov 2025
Primary completion
Jan 31, 2029
Completion
May 31, 2029

Study Design

Enrollment
42 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Cardiac Rehabilitation
    Participants will participate in a 12-week cardiac rehabilitation program
  • Placebo Comparator: Attention Control
    Participants will not participate in a cardiac rehabilitation program and will receive phone calls in place of cardiac rehabilitation visits.

Primary Outcome Measure

Impact of Cardiac Rehabilitation training on single protein changes [ Time Frame: 12 weeks ]

Central Contacts

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