Heart disease Clinical Trials

Recruiting heart disease studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat heart disease. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting heart disease studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting heart disease trials

Within

Real-world Study to Describe the Effectiveness and Safety Outcomes of Jardiance in Chinese Patients With Heart Failure and Preserved Ejection Fraction

for Heart Failure

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT07047508

Mobile Health Management of Hypertension

for Hypertension

1 site in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT05856955

Conscious Sedation Study

for Atrial Fibrillation

Sponsor: Conformal Medical, Inc

Sex: All·Age: 18+

Code: NCT06049615

Effect of Propionic Acid Supplementation on Endothelial Function

for Cardiovascular Diseases

Sponsor: Medical College of Wisconsin

Sex: All·Age: 40 - 75

Code: NCT05135702

Monitoring Blood Pressure at Home and Pharmacy Telehealth

for Hypertension

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18+

Code: NCT07623291

The Effectiveness of Patch-Based Screening for Pre-Symptomatic Atrial Fibrillation to Improve Patient Outcome

for Atrial Fibrillation

1 site in Palo Alto

Sponsor: VA Office of Research and Development

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT06953778

OPTIA-AF Trial: Rhythm-Guided Antithrombotic Strategy After AF Ablation

for Atrial Fibrillation (AF)

Sponsor: Ewha Womans University Mokdong Hospital

Sex: All·Age: 18+

Code: NCT07496281·Phase 4

Optimizing Care For Management Of Hard To Control Hypertension In Low-Income Patients Across Family Health Centers In New York City

for Hypertension

1 site in New York

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT07703423

Registry on Luma Vision's VERAFEYE System (ENLIgHT)

for Atrial Fibrillation

Sponsor: LUMA Vision Ltd.

Sex: All·Age: 18+

Code: NCT06293430

Rapid Inflation/Deflation Compared With Prolonged High-Pressure Balloon Inflation

for Coronary Artery Disease

1 site in Little Rock

Sponsor: Central Arkansas Veterans Healthcare System

Sex: All·Age: 19+

Code: NCT01952873

Pragmatic Amiodarone Trial to Reduce Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery

for Surgery, Cardiac

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05543278·Phase 4

A Study of the Effect of a Nurse Navigator Program on High Risk Patients

for Patient Readmission

1 site in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05592847

ReVeRA-301: Etripamil in Atrial Fibrillation Phase 3

for Atrial Fibrillation

Sponsor: Milestone Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT06716021·Phase 3

Biventricular Remodeling in Transcatheter Tricuspid Valve Replacement - Acute Hemodynamic Instability Study

for Tricuspid Regurgitation

1 site in New York

Sponsor: Columbia University

Sex: All·Age: 18+

Code: NCT06954792

Feasibility and Acceptability of Three Component Intervention for the Heart Failure Care for Rural Dwelling Participants

for Heart Failure

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18+

Code: NCT07103239

Community Hypertension Control Using the Health Belief Model and PRECEDE-PROCEED

for Hypertension

Sponsor: Bangladesh Medical University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07426978

Safety and Efficacy of Low-dose Anticoagulation With Argatroban and Enoxaparin on ECMO

for Pneumonia

Sponsor: University Hospital Ostrava

Sex: All·Age: 18+

Code: NCT07499037·Phase 2

Nursing Intervention for Adaptation After Myocardial Revascularization

for Coronary Artery Disease

Sponsor: Universidad de la Sabana

Sex: All·Age: 18+

Code: NCT07576569

Utilizing Carbon Dioxide for Assessing Coronary Blood Flow in Subjects With Coronary Artery Disease

for Coronary Artery Disease

1 site in Indianapolis

Sponsor: Indiana University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06253884

TA-65 and Aging Associated Microvascular Dysfunction

for Telomere Shortening

Sponsor: Medical College of Wisconsin

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT05598359

Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)

for Obesity and Obesity-related Medical Conditions

1 site in Columbia

Sponsor: Bettina Mittendorfer

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT07083557

Apply to this trial

Relaxin Therapy for Atrial Fibrillation

for Atrial Fibrillation (AF)

Sponsor: Deeptankar DeMazumder

Sex: All·Age: 18+

Code: NCT07359872·Phase 1, Phase 2

Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress

for Critical Illness

3 sites incl. Los Angeles

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07634419

Comparing Two Heart Medicines for Fast, Irregular Heartbeat (Atrial Fibrillation)

for Atrial Fibrillation (AF)

Sponsor: Muhammad Ali Javed

Sex: All·Age: 18+

Code: NCT07706075·Phase 4

An AI-ECG-Based Approach for Dynamic Assessment of Heart Failure Risk and Myocardial Recovery Following Atrial Fibrillation Ablation

for Atrial Fibrillation (AF)

Sponsor: Ewha Womans University Mokdong Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07708818

PAtient Similarity for Decision-Making in Prevention of Cardiovascular Toxicity (PACT): A Feasibility Study

for Heart Failure

1 site in Milwaukee

Sponsor: Medical College of Wisconsin

Sex: All·Age: 18+

Code: NCT05377320

Predicting Severe Cardiac Arrhythmias in the Perioperative Period Using AI-ECG

for Atrial Fibrillation

Sponsor: I.M. Sechenov First Moscow State Medical University

Sex: All·Age: 18+

Code: NCT07348991

Computerized Decision Support to Prevent Stroke in Atrial Fibrillation

for Atrial Fibrillation

2 sites incl. Edgewood

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06355986

Pulmonary Artery Denervation for Heart Failure With Preserved Left Ventricular Ejection Fraction

for Heart Failure With Preserved Ejection Fraction

Sponsor: Nanjing First Hospital, Nanjing Medical University

Sex: All·Age: 18 - 85

Code: NCT07331220

PCI With GDMT Versus GDMT Alone for Patients With Ischemic Cardiomyopathy and Reduced LVEF

for Heart Failure With Reduced Ejection Fraction

Sponsor: Nanjing First Hospital, Nanjing Medical University

Sex: All·Age: 18+

Code: NCT07349979

VITAL-IMPACT: Improving Cardiometabolic Health in Black Individuals Through Therapeutic Augmentation of Cyclic Guanosine Mono-Phosphate Signaling Pathway

for Cardiovascular Diseases

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT06320951·Phase 2

Data-Driven Phenotyping in Heart Failure With Preserved Ejection Fraction

for Heart Failure

Sponsor: Instituto Politécnico de Leiria

Sex: All·Age: 18+

Code: NCT07429396

FENOX Trial (Comparative Effectiveness of Fexuprazan Co-therapy in Patients Receiving Non-Vitamin K Antagonist Oral Anticoagulants)

for Atrial Fibrillation (AF)

Sponsor: Ewha Womans University Mokdong Hospital

Sex: All·Age: 18+

Code: NCT07497893

A Study to Investigate Efficacy and Safety of a TCA108 in Participants ≥18 Years With Uncontrolled Hypertension

for Hypertension

Sponsor: EMS

Sex: All·Age: 18+

Code: NCT07030101·Phase 3

CGM Use in Heart Failure

for Heart Failure

1 site in Atlanta

Sponsor: Emory University

Sex: All·Age: 18 - 90

Code: NCT07045298

A Clinical Study Comparing Ankle Swelling Caused by Two Different Blood Pressure Medications, Levamlodipine and Amlodipine, in Post-menopausal Women With Mild High Blood Pressure.

for Hypertension

Sponsor: Zentiva, k.s.

Sex: Female·Age: 50 - 79

Code: NCT07618806·Phase 3

Value of Potassium Magnesium Citrate in Preventing and Treating Hypertension in African Americans

for Hypertension

1 site in Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT05145309·Phase 2

Metabolic Surgery for Atrial Fibrillation Elimination

for Atrial Fibrillation

1 site in Cleveland

Sponsor: Ali Aminian

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07027969·Phase 4

Semaglutide PrIor to CathEeter Ablation in Patients With Atrial Fibrillation

for Atrial Fibrillation (AF)

Sponsor: University of Luebeck

Sex: All·Age: 18+

Code: NCT07389941·Phase 4

Consciousness Studies and Cardiovascular Health

for Blood Pressure

1 site in Miami

Sponsor: University of Miami

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07620639

A Study to Evaluate the Effect of Two Fixed-Dose Leucine, Sildenafil and Metformin Combinations on Blood Pressure in Individuals With Hypertension

for Hypertension

Sponsor: NuSirt Biopharma

Sex: All·Age: 18 - 75

Code: NCT07647003·Phase 2

Isolation of Pulmonary Veins Using the Box Technique in Patients Undergoing Sternotomy

for Atrial Fibrillation (AF)

Sponsor: Nantes University Hospital

Sex: All·Age: 18+

Code: NCT07312149

Health Coaching for Patients With Cardiovascular Disease

for Congestive Heart Failure Treated

1 site in Columbus

Sponsor: Ohio State University

Sex: All·Age: 18+

Code: NCT06904144

Guided Physical Activity Counseling for Hypertension in Primary Care

for Physical Activity

Sponsor: University of California, San Diego

Sex: All·Age: 18 - 80

Code: NCT07342543

Enhancing Mental and Physical Health of Women Veterans 3.0

for Cardiovascular Diseases

1 site in West Los Angeles

Sponsor: VA Office of Research and Development

Sex: All·Age: All ages

Code: NCT07356479

AI-Assisted Workflow for Occult Atrial Fibrillation Detection After Ischemic Stroke: A Prospective Randomized Trial

for Atrial Fibrillation

Sponsor: National Taiwan University Hospital

Sex: All·Age: 18+

Code: NCT07540065

Remote Monitoring and Optimization of Heart Failure Therapy

for Heart Failure

Sponsor: Zoll Medical Corporation

Sex: All·Age: 18 - 85

Code: NCT07622472

Evaluating the Effects of a Mindfulness Intervention on Health Outcomes in Individuals With Hypertension

for Hypertension

1 site in Columbus

Sponsor: Ohio State University

Sex: All·Age: 18+

Code: NCT07679984

INTEGRATE-RX: Integrating Clinical Pharmacists in HIV Care to Mitigate Last-Mile Challenges and Reduce Cardiovascular Disease Burden

for HIV

Sponsor: Temple University

Sex: All·Age: 18 - 75

Code: NCT07711366

Vernakalant Versus Amiodarone for Post-operative Atrial Fibrillation in Cardiac Surgery Patients

for Atrial Fibrillation

Sponsor: University of Calgary

Sex: All·Age: 18+

Code: NCT04748991·Phase 3

Estrogen Deficiency on Cardiovascular Risk

for Postmenopausal Symptoms

Sponsor: Milton S. Hershey Medical Center

Sex: Female·Age: 54 - 75·Accepts healthy volunteers

Code: NCT06369363·EARLY_Phase 1

LEFT ATRIAL MONITORING IN PATIENTS BEFORE AND AFTER MITRAL SURGERY - LAMBDA STUDY

for Mitral Regurgitation

Sponsor: Ottawa Heart Institute Research Corporation

Sex: All·Age: 18+

Code: NCT06547788

Flecainide Safety in Patients With Coronary Artery Disease and Atrial Fibrillation

for Atrial Fibrillation (AF)

Sponsor: Universitaire Ziekenhuizen KU Leuven

Sex: All·Age: 18+

Code: NCT07405671·Phase 4

AF-CARD Registry (Real-World Clinical Practice Registry of Patients With Atrial Fibrillation)

for Atrial Fibrillation (AF)

Sponsor: Eurasian Association of Therapists

Sex: All·Age: 18 - 64

Code: NCT07437456

Impact of Combined Cardio-pulmonary Assessment on COPD Clinical Management.

for COPD (Chronic Obstructive Pulmonary Disease)

Sponsor: University of Bari Aldo Moro

Sex: All·Age: 41+

Code: NCT07481825

Cardiologist-Administered Midazolam vs. Anaesthesiologist-Assisted Propofol Sedation For Transoesophageal Echocardiography-Guided Cardioversion of Atrial Fibrillation

for Atrial Fibrillation (AF)

Sponsor: Gødstrup Hospital

Sex: All·Age: 18+

Code: NCT07571447·Phase 4

Bedside Assessment of Right Ventricular Output Lying in Prone Or Supine Position

for Right Ventricular Function

Sponsor: Sahlgrenska University Hospital

Sex: All·Age: 18+

Code: NCT07632027

Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord Injury

for Spinal Cord Injuries

1 site in West Orange

Sponsor: Kessler Foundation

Sex: All·Age: 18 - 75

Code: NCT07674511

DIALOZIC - Pilot Study of a Diagnostic Pathway for Heart Failure in Rural Areas: the Contribution of Telebiology and Telemedicine

for Heart Failure

Sponsor: University Hospital, Montpellier

Sex: All·Age: 60+

Code: NCT07682545

N-of-1 Trial to Promote Beta-Blocker Titration in Heart Failure

for Heart Failure

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 60+

Code: NCT07489352

Heart disease clinical trials — common questions

Are heart disease clinical trials free to join?

Yes. Participating in a heart disease clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a heart disease clinical trial?

Each heart disease study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a heart disease trial near me?

Use the location controls above. We'll show recruiting heart disease trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many heart disease trials are recruiting right now?

We're currently tracking roughly 973 recruiting heart disease trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Heart disease trials by city

Boston, MA Birmingham, AL Chicago, IL Cleveland, OH Los Angeles, CA San Francisco, CA Aurora, CO Columbus, OH Miami, FL Palo Alto, CA Stanford, CA Ann Arbor, MI

Conditions in this area

Heart failure Hypertension (high blood pressure)Atrial fibrillation Coronary artery disease Myocardial infarction (heart attack)Cardiovascular disease (general)Congenital heart disease