Optimal Pediatric Heart Transplant Immunosuppression With MicroRNAs

Part of paid clinical trials in Aurora, Colorado.

Sponsor
Northwestern University
Study ID
NCT06532890
Status
Recruiting
Apply to this trial

Conditions

  • Cardiac Failure
  • Graft Rejection

Eligibility Criteria

Sex
ALL
Age
N/A - 18 Years
Healthy Volunteers
Not accepted

Study Details

This study aims to discover circulating microRNAs (associated with drug doses and levels) that can be used to characterize the overall immune state in pediatric heart transplant patients and predict patients that will go on to develop infection and rejection. MicroRNAs (miRs) are small, non-coding RNA molecules that regulate gene expression and serve as molecular biomarkers found in the circulation.

Key Dates

First listed
Aug 1, 2024
Start date
Feb 6, 2025
Status verified
Aug 2026
Primary completion
Oct 1, 2029
Completion
Oct 1, 2029

Study Design

Enrollment
150 participants (estimated)

Primary Outcome Measure

Time-to-Event Analysis of Circulating microRNAs (miRs) Predicting Infection in Pediatric Heart Transplant Recipients [ Time Frame: up to 2 years post-transplant ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
Children's Hospital ColoradoAuroraColorado80045
Rebecca Hill
[email protected]
Shelley Miyamoto, MD (PRINCIPAL_INVESTIGATOR)
Ann & Robert H. Lurie Children's Hospital of ChicagoChicagoIllinois60611
Stephanie Brazis
[email protected]
(312) 227-0201
Defne Magnetta (SUB_INVESTIGATOR)
University of MichiganAnn ArborMichigan48109
Christine Cislo
[email protected]
David Peng, MD (PRINCIPAL_INVESTIGATOR)
Columbia UniversityNew YorkNew York10032
Marc Richmond, MD (PRINCIPAL_INVESTIGATOR)
University of PittsburghPittsburghPennsylvania15224
Kyla Thorn
[email protected]
4126926061
Brian Feingold, MD (PRINCIPAL_INVESTIGATOR)
Vanderbilt UniversityNashvilleTennessee37232
Darlene Fountain
[email protected]
David Bearl, MD (PRINCIPAL_INVESTIGATOR)
Texas Children's HospitalHoustonTexas77030
Blake Fallon
[email protected]
Joseph Spinner, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Aurora, CO

By research site
Children's Hospital Colorado· Aurora, COAnn & Robert H. Lurie Children's Hospital of Chicago· Chicago, ILUniversity of Michigan· Ann Arbor, MIColumbia University· New York, NYUniversity of Pittsburgh· Pittsburgh, PAVanderbilt University· Nashville, TN

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