Effect of Esterogen Receptor Modulator on Gene in Bipolar Diseas

Sponsor
Assiut University
Study ID
NCT06580535
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
15 Years - 70 Years
Healthy Volunteers
Not accepted

Interventions

  • blood sample — OTHER
    Blood sample taking from patient for tissue culture

Study Details

1. Identify randomized controlled trials of tamoxifen (Estrogen Receptor modulator) in in addition to traditional treatment of bipolar disorder and synthesize the results using meta-analysis. 2. Systematically estimate the effects of Phospholipase C epsilon 1 gene (PLCE1) rs2274223and gene polymorphism on the susceptibility to treatment. 3. Study the pathway involved in the action of tamoxifen by incorporating TMX into nanoparticles and evaluating tyrosine kinase in responders WBCS culture and evaluate nanoparticle as a hope for future treatment of CNS disorders.

Key Dates

First listed
Aug 30, 2024
Start date
Sep 5, 2024
Status verified
Aug 2024
Primary completion
Aug 31, 2025
Completion
Dec 31, 2025

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: group 1 (patients)
    50 patients assigned to receive treatment of bipolar disorder
  • Arm: Group 2 recrutied blood from patients
    GroupII:50 blood sample will be recruited from G1for in vitro tissue culture to study the effect of tamoxifen on the WBCs of patients
  • Arm: group 3 control
    GroupIII:50 healthy control will be recruited (age and sex will be matched

Primary Outcome Measure

change in Young Mania Rating Scale(YMRS) Score [ Time Frame: e.g.4 weeks ]

Central Contacts

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