Mental health Clinical Trials

Recruiting mental health studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat mental health. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting mental health studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting mental health trials

Within

Personalized Pharmaco-Lifestyle Interventions for Severe Mental Illnesses (LIFETRAIN)

for Severe Mental Illness

Sponsor: Ludwig-Maximilians - University of Munich

Sex: All·Age: 18 - 65

Code: NCT07586150

The Development of a Transdiagnostic Intervention to Improve Social Functioning and Intimate Relationships Among Veterans

for Alcohol Problems

1 site in Bedford

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT06746727

Whole-Body Hyperthermia for Mood and Anxiety Disorders

for Postpartum Depression

1 site in New York

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18 - 50·Accepts healthy volunteers

Code: NCT06144294

INNOV5-MH-MAROC: Integrated Mental Health Care for Adolescents and Adults in Primary Care Centers and Schools in Morocco

for Depression in Adolescence

Sponsor: Swiss Medical Academy Maroc

Sex: All·Age: 12+

Code: NCT07258095

Collaborative Care Intervention for Cancer Patients and Their Family Caregivers -LITE

for Cancer

2 sites in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 21 - 100·Accepts healthy volunteers

Code: NCT05601206

ACT for Veterans With IBD and Mental Health Challenges

for Inflammatory Bowel Diseases

1 site in Houston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07397195

Pilot Randomized Trial of BA-GSH in VA PC-MHI

for Depression

1 site in Houston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07541482

CBT for Adult Inmates With ADHD

for Attention Deficit Hyperactivity Disorder

Sponsor: Universidad Europea de Valencia

Sex: All·Age: 18+

Code: NCT06080373

Developing a Virtual Reality-assisted Intervention for Emotion Regulation Difficulties in Psychosis

for Psychosis

Sponsor: King's College London

Sex: All·Age: 18+

Code: NCT07623928

Prevalence of Depression Among Patients With Alopecia Areata

for Alopecia Areata Depression

Sponsor: Sohag University

Sex: All·Age: 18 - 100

Code: NCT07711574

Department of Defense PTSD Adaptive Platform Trial - Intervention B - Vilazodone

for Post Traumatic Stress Disorder

Sponsor: Global Coalition for Adaptive Research

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT05948579·Phase 2

Adapting a Telehealth Intervention for Suicide Prevention Among Patients With Alcohol Use Disorder in Tanzania

for Alcohol Use Disorder

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07475988

Mental Health INtervention With Digital APPlications (MIND-APP): Randomized Controlled Researcher Blinded Trial Evaluating the Effectiveness of the Tankevirus and Grubl Mental Health Apps

for Anxiety

Sponsor: University Hospital, Akershus

Sex: All·Age: 16+

Code: NCT07627204

Developing and Piloting an Implementation Strategy for a Brief, Motivational Interviewing-based Lethal Means Safety Counseling Intervention in Primary Care Settings

for Suicide Prevention

1 site in West Haven

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07247916

Virtual Intervention for Behavioral Health in Emerging Adults; "VIBE in the Parks"

for Anxiety

Sponsor: University of Illinois at Chicago

Sex: All·Age: 13 - 24

Code: NCT07539636

Cognitive Training for Functioning in PTSD

for Posttraumatic Stress Disorder

1 site in San Diego

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07693686

Stony Brook Medicine Anti-Inflammatory Trial

for Major Depressive Disorder

Sponsor: Stony Brook University

Sex: All·Age: 18 - 65

Code: NCT06699966·Phase 4

Remotely Administered tDCS to Improve Cognitive Function in Veterans With mTBI and PTSD Principal Investigator

for Cognition

1 site in Philadelphia

Sponsor: VA Office of Research and Development

Sex: All·Age: 20 - 75

Code: NCT07414537·Phase 2

Efficacy of a Personalized, Response-based Transdiagnostic Intervention for Emotional Disorders Delivered Via the Internet: A Protocol for an Adaptive Randomized Controlled Trial

for Emotional Disorders

Sponsor: Universitat Jaume I

Sex: All·Age: 18 - 70

Code: NCT07051148

Frontal Gamma Coherence Neurofeedback for Patients With Schizophrenia

for Schizophrenia

1 site in La Jolla

Sponsor: BioSignal Solutions LLC

Sex: All·Age: 18 - 55

Code: NCT07659938

A Mobile Health Intervention to Improve Psychosocial Functioning in Veterans With Posttraumatic Stress Disorder and Depression Symptoms

for Psychosocial Functioning

1 site in Palo Alto

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT06689787

Understanding Non-invasive Vagus Nerve Stimulation Effects in PTSD

for PTSD - Post Traumatic Stress Disorder

1 site in Detroit

Sponsor: Wayne State University

Sex: All·Age: 18 - 80

Code: NCT06953388·EARLY_Phase 1

Locating Biomarkers in OCD Through Behavioral Tasks

for OCD

3 sites incl. Pittsburgh

Sponsor: Baylor College of Medicine

Sex: All·Age: 18 - 65

Code: NCT03313622

Technology dRiven Enhancement to Engage & Connect

for Depression

1 site in New York

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 50 - 80

Code: NCT06910683

A Clinical Trial of Iron Supplementation for Youth With ADHD and Restless Sleep

for ADHD

1 site in Baltimore

Sponsor: Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

Sex: All·Age: 8 - 18

Code: NCT07061470·Phase 1, Phase 2

Pivotal U.S. Clinical Validation of AI-COA® for Depression and Anxiety

for Depression Disorders

1 site in Houston

Sponsor: Deliberate Solutions Inc.

Sex: All·Age: 18 - 65

Code: NCT07279038

Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE)

for Knee Osteoarthritis

1 site in Baltimore

Sponsor: VA Office of Research and Development

Sex: All·Age: 40+·Accepts healthy volunteers

Code: NCT07649291·Phase 2

Community Health Worker Implementation of Transdiagnostic Evidence-based Mental Health Intervention for Spanish-speaking Latine Parents

for Depression

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT07390630

Benefits of Exergames on Neurocognitive Functions in Adults Suffering From Depression

for Depression

Sponsor: MAP Institute

Sex: All·Age: 18 - 65

Code: NCT06536530

Implementation of a Just-In-Time Adaptive Intervention for Adolescent Anxiety

for Anxiety

Sponsor: Trustees of Dartmouth College

Sex: All·Age: 13 - 17

Code: NCT06946823

Quantifying Multi-step Avoidance in Anxiety

for Anxiety

2 sites in Atlanta

Sponsor: Emory University

Sex: All·Age: 22 - 55·Accepts healthy volunteers

Code: NCT07203027

Personalizing Mental Health Treatment for Youth and Families

for Anxiety

Sponsor: University of Oregon

Sex: All·Age: 5 - 15

Code: NCT07425366

Group PACBT for Depression

for Depression - Major Depressive Disorder

1 site in Los Angeles

Sponsor: University of California, Los Angeles

Sex: All·Age: 21 - 60

Code: NCT07566104·Phase 2

Comparative Effects of Four Brief Breathwork and Mindfulness Interventions on Anxiety and Psychological Flexibility: A 4-Arm RCT

for Anxiety

Sponsor: Valencian International University (VIU)

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07621042

rTMS for Aneroxia Nervosa in Youth

for Anorexia Nervosa

Sponsor: University of California, Los Angeles

Sex: All·Age: 14 - 24

Code: NCT04846517

A Randomized Controlled Trial of a Smartphone Delivered Treatment for Suicidal Thoughts and Behavior

for Suicidal Ideation

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06686901

A Phase I/II Study of PDC-1421 for Treating Depression in Cancer Patients

for Major Depressive Disorder

1 site in Los Angeles

Sponsor: BioLite, Inc.

Sex: All·Age: 21 - 85

Code: NCT03833206·Phase 1, Phase 2

Immersive VR to Reduce Stress, Anxiety, and Pain During PICC/Midline Placement

for Vasoconstriction

Sponsor: diana garcia

Sex: All·Age: 18+

Code: NCT07696156

Improving Mental Healthcare Outcomes for Minoritized Veterans Through a Peer-led, Patient Navigation Program (PARTNER-MH 2.0)

for Diagnoses of Depression

2 sites incl. Indianapolis

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07645274

Shared Decision Making for Antipsychotic Medications

for Schizophrenia

Sponsor: New York State Psychiatric Institute

Sex: All·Age: 18 - 30

Code: NCT05416658

Therapeutic Ketogenic Diet in Partial Hospital Program (PHP) Anorexia Nervosa

for Anorexia Nervosa

1 site in San Diego

Sponsor: University of California, San Diego

Sex: All·Age: 16 - 45

Code: NCT06605027

Brain Network Mechanisms of Cognitive Impairments in Major Psychiatric Disorders and Their Clinical Applications

for Schizophrenia

Sponsor: Central South University

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT07444463

Accelerated iTBS for Depression and Suicidality

for Major Depressive Disorder

Sponsor: University of Iowa

Sex: All·Age: 18 - 90

Code: NCT04441008

Mobile Thinking Intervention: A Inital Test

for Schizophrenia

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18 - 65

Code: NCT06909422

Crisis Response Planning in Military Personnel With Mild Traumatic Brain Injury

for Mild Traumatic Brain Injury

1 site in Fort Hood

Sponsor: The University of Texas Health Science Center at San Antonio

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07327567

Sham-Controlled Rapid-Acting Neuromodulation for Depression

for Depression - Major Depressive Disorder

1 site in Sacramento

Sponsor: University of California, Davis

Sex: All·Age: 18 - 65

Code: NCT07487454

Trial of a Nurse-Led Firearm Safety Intervention in the Pediatric Inpatient Setting

for Firearm Safety

2 sites in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT07501247

Feasibility and Acceptability of Mobile Mental Health App for SZ and SZA

for Schizophrenia

Sponsor: University of Pittsburgh

Sex: All·Age: 18 - 60

Code: NCT06474325

Music and VR Effects on Pain, Anxiety, and Fear During Oral Mucositis Care in Leukaemic Children

for Anxiety

Sponsor: Ege University

Sex: All·Age: 6 - 12

Code: NCT06955338

Crisis Interventions for Pediatric Providers - Autism Version

for Autism

1 site in Los Angeles

Sponsor: Children's Hospital Los Angeles

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07508436

Longitudinal PET Imaging of Antipsychotic Binding to the Dopamine-3 Receptor in Schizophrenia

for Schizoaffective Disorder

Sponsor: New York State Psychiatric Institute

Sex: All·Age: 18 - 55

Code: NCT07715253·Phase 1

Treatment of Depression Post-SCI

for Depression

1 site in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 70

Code: NCT04263285

Apply to this trial

MDMA-Assisted Therapy for Stress Disorders in Healthcare Workers and First Responders

for Post-Traumatic Stress Disorder

3 sites incl. Boulder

Sponsor: Nautilus Sanctuary

Sex: All·Age: 18+

Code: NCT05455996·Phase 2

Study of Bedroom Environment Sleep Intervention at Home for Older Adults Living Alone With Memory Concerns

for Subjective Cognitive Decline (SCD)

Sponsor: Johns Hopkins University

Sex: All·Age: 65+

Code: NCT07440498

Postnatal Debriefing After Adverse Obstetric Events

for Stress Disorders, Post-Traumatic

Sponsor: Parc de Salut Mar

Sex: Female·Age: 18+

Code: NCT07579273

Cognitive Processing Therapy for Posttraumatic Stress Disorder and Co-occurring Lived Experience Stress

for Post Traumatic Stress Disorder

1 site in Jamaica Plain

Sponsor: Boston University

Sex: All·Age: 18+

Code: NCT07714083

Efficacy of Digital CBT-I Utilizing Embodied Artificial Intelligence Agent in Virtual Reality

for Insomnia

Sponsor: Chinese University of Hong Kong

Sex: All·Age: 18 - 65

Code: NCT07699042

Digital Implementation Support to Achieve Uptake and Integration of Task-Shared Care for Schizophrenia in Primary Care in India

for Schizophrenia

Sponsor: Harvard Medical School (HMS and HSDM)

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06043778

Self-Help Intervention for Post 9/11 Veterans With Depression or PTSD Symptoms

for Depression

2 sites incl. Syracuse

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07202325

Enhancing Mental and Physical Health of Women Veterans 3.0

for Cardiovascular Diseases

1 site in West Los Angeles

Sponsor: VA Office of Research and Development

Sex: All·Age: All ages

Code: NCT07356479

Mental health clinical trials — common questions

Are mental health clinical trials free to join?

Yes. Participating in a mental health clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a mental health clinical trial?

Each mental health study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a mental health trial near me?

Use the location controls above. We'll show recruiting mental health trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many mental health trials are recruiting right now?

We're currently tracking roughly 1811 recruiting mental health trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Mental health trials by city

Boston, MA Los Angeles, CA San Francisco, CA San Diego, CA Chicago, IL Palo Alto, CA Aurora, CO Columbus, OH Birmingham, AL Stanford, CA Ann Arbor, MI Miami, FL

Conditions in this area

Depression Anxiety PTSD (post-traumatic stress disorder)Bipolar disorder Schizophrenia Obsessive-compulsive disorder (OCD)ADHD Eating disorders Suicidal ideation / suicide Mood disorders Insomnia