Bipolar disorder Clinical Trials

Recruiting bipolar disorder studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat bipolar disorder. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting bipolar disorder studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting bipolar disorder trials

Within

Brain Network Mechanisms of Cognitive Impairments in Major Psychiatric Disorders and Their Clinical Applications

for Schizophrenia

Sponsor: Central South University

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT07444463

Evaluating the Impact of Ketogenic Therapy on Symptom Severity and Metabolic Side Effect Profile Among Individuals Living With Bipolar Disorder in A Rural Southern Catchment Area

for Bipolar Disorder

1 site in Montgomery

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18+

Code: NCT07570875

Enhancing Veteran-Clinical Collaboration in VA PRRCs

for Schizophrenia

3 sites incl. San Diego

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT06898879

Functional Magnetic Resonance Imaging Study of Inhibitory Control in Bipolar Disorder and Major Depressive Disorder

for Bipolar Disorder

Sponsor: CHU de Reims

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07503275

The Effect of Comorbid Alcohol/Substance Use

for Alcohol Abuse

Sponsor: Abant Izzet Baysal University

Sex: All·Age: 18 - 65

Code: NCT07692984

Apply to this trial

A Study Of Senyo Health With Comorbid Alcohol Use Disorder Treatment In Bipolar Patients

for Bipolar Disorder

1 site in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07556861

Emotional Eating, Sleep Quality, Mental State and Metabolic Syndrome

for Schizophrenia

Sponsor: Abant Izzet Baysal University

Sex: All·Age: 18 - 65

Code: NCT07411222

Venous Tourniquet vs. Arterial Tourniquet for Seizure Monitoring in ECT

for Major Depressive Disorder

Sponsor: Medipol University

Sex: All·Age: 18 - 65

Code: NCT07534475

Empagliflozin Adjunctive Therapy in Bipolar Depression

for Bipolar Disorder

Sponsor: University of Sao Paulo

Sex: All·Age: 18 - 65

Code: NCT07472920

CBT-CP for Veterans With SMI

for Chronic Pain

1 site in Baltimore

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT06758414

Apply to this trial

Mindfulness-Based Therapy for Serious Mental Illness

for Serious Mental Illness

1 site in Providence

Sponsor: Butler Hospital

Sex: All·Age: 18+

Code: NCT06880796

A Study of Brenipatide in Adult Participants With Bipolar Disorder (RENEW-Bipolar-1)

for Bipolar Disorder

20 sites incl. Orange

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT07286175·Phase 2

Apply to this trial

Visual Perception in Schizophrenia

for Schizophrenia Disorders

1 site in Rochester

Sponsor: University of Rochester

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06911931

Apply to this trial

Group Intervention for Romantic Relationships in Young Adults With Severe Mental Illness

for Severe Mental Illness

Sponsor: Centre hospitalier de Ville-Evrard, France

Sex: All·Age: 18+

Code: NCT07316803

Apply to this trial

Biomarker Research on Ultra-High-Field MRI Combined With Visual Perception Assessment in the Diagnosis and Treatment Outcomes of Severe Mental Disorders

for Major Depressive Disorder (MDD)

Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07479758

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An Open-label Study of Azetukalner in Bipolar I or II Depression (X-CEED-OLE)

for Bipolar Depression

15 sites incl. Little Rock

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 18 - 75

Code: NCT07217860·Phase 3

A Study of Olanzapine in Participants With Bipolar Disorder.

for Bipolar Disorder

Sponsor: Boryung Pharmaceutical Co., Ltd

Sex: All·Age: 19+

Code: NCT07263191

Apply to this trial

A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine

for Mania

20 sites incl. Bentonville

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18 - 65

Code: NCT07140913·Phase 3

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NeuroPsyBiT-BD Omics: Genomic & Epigenomic Biobank of Bipolar Disorder

for Bipolar Disorder

Sponsor: Selçuk State Hospital

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07173842

Approaches For ThE pRioritization of Patients in priMAry Care Post-COVID To Reduce Health Inequities (AFTERMATH)

for Schizophrenia

Sponsor: Unity Health Toronto

Sex: All·Age: 18+

Code: NCT05823805

A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor

for Schizophrenia

22 sites incl. Bryant

Sponsor: Neurocrine Biosciences

Sex: All·Age: 18+

Code: NCT07105111·Phase 4

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A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)

for Bipolar Disorder

28 sites incl. Tucson

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 18 - 74

Code: NCT07172516·Phase 3

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Ketogenic Metabolic Therapy in Schizophrenia, Bipolar Disorder, Major Depressive Disorder: Deep Omic Profiling

for Schizophrenia

1 site in Palo Alto

Sponsor: Stanford University

Sex: All·Age: 18 - 80

Code: NCT06748950

Mindfulness Psychoeducation for Bipolar Disorder Caregivers' Mindfulness, Burden, Quality of Life and Resilience

for Bipolar Disorder

Sponsor: Pamukkale University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06983834

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Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study

for Major Depressive Disorder

1 site in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06897670

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Mechanisms of Transcutaneous Auricular Vagus Nerve Stimulation in Depression

for Depressive Disorder

Sponsor: Max-Planck-Institute of Psychiatry

Sex: All·Age: 18 - 65

Code: NCT07022171

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Enhancing Rehabilitation for Veterans With Serious Mental Illness

for Schizophrenia

1 site in San Diego

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 83

Code: NCT06586164

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Evaluation of the Impact of the EDIT-B® Blood Test on the Health Status of Patients Presenting a Major Depressive Episode. Clinical Utility and Medico-Economic Aspects

for Bipolar Disorder

Sponsor: Alcediag

Sex: All·Age: 18 - 65

Code: NCT06507787

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Obstructive Sleep Apnea Treatment in Serious Mental Illness

for Schizoaffective Disorder

1 site in La Jolla

Sponsor: University of California, San Diego

Sex: All·Age: 40 - 70·Accepts healthy volunteers

Code: NCT05457127

Healthy Lifestyles in Bipolar Disorder: Bay Area Study

for Bipolar Disorder

1 site in Berkeley

Sponsor: University of California, Berkeley

Sex: All·Age: 18 - 65

Code: NCT06555406

Apply to this trial

A Cohort Study of Disease Prediction Model for High-risk Population With Bipolar Disorder

for High-risk

Sponsor: Shanghai Mental Health Center

Sex: All·Age: 6 - 18·Accepts healthy volunteers

Code: NCT07031661

Apply to this trial

Psychoneuromentalism Disorder: A Medical Condition That Affects People With Psychological Impairments From Health Issues

for Schizoaffective Disorder, Bipolar Type

Sponsor: The Essence of Integrative Health and Medicine Practice

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT06235177·EARLY_Phase 1

Intermittent Theta Burst Stimulation (iTBS) for Emotion Regulation in Bipolar Disorder

for Bipolar Disorder

2 sites incl. Charlestown

Sponsor: Massachusetts General Hospital

Sex: All·Age: 24 - 65

Code: NCT06274567

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mHealth Estimate-based Algorithms Signaling Upcoming Recurrence of Episodes in Bipolar Disorders

for Bipolar Disorder

1 site in Minneapolis

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT06204705

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Effect of Esterogen Receptor Modulator on Gene in Bipolar Diseas

for Bipolar Disorder

Sponsor: Assiut University

Sex: All·Age: 15 - 70

Code: NCT06580535

Taking Action for College Students

for Major Depressive Disorder

1 site in Philadelphia

Sponsor: Temple University

Sex: All·Age: 18+

Code: NCT06700902

Apply to this trial

A Biological Signature for the Early Differential Diagnosis of Psychosis

for Schizophrenia

Sponsor: IRCCS San Raffaele

Sex: All·Age: 18 - 65

Code: NCT06515522

Magnetic Seizure Therapy in Bipolar Depression (MST-BpD) and Treatment Resistant Depression (MST-TRD)

for Bipolar Disorder

1 site in Houston

Sponsor: Joao L. DeQuevedo

Sex: All·Age: 22 - 85

Code: NCT04080778

Apply to this trial

Physical Exercise for Cognitive Rehabilitation of Patients With Bipolar Affective Disorder

for Bipolar Disorder

Sponsor: Beny Lafer

Sex: All·Age: 18 - 60

Code: NCT06560749

Apply to this trial

Correcting Circadian Rhythms to Breakthrough in Bipolar Disorder

for Bipolar Disorder

1 site in Ann Arbor

Sponsor: Leslie Swanson

Sex: All·Age: 18 - 60

Code: NCT06226025·Phase 2

Apply to this trial

Personalized Mobile Cognitive Behavioral Therapy Application

for Anxiety Disorders and Symptoms

1 site in New York

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18 - 25

Code: NCT05699525

Apply to this trial

Neuro-computational Study of Thymic Fluctuations in Mood Disorders

for Depression

Sponsor: Centre Hospitalier St Anne

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07033923

Apply to this trial

Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy

for Suicidal Ideation

1 site in Grand Rapids

Sponsor: Michigan State University

Sex: All·Age: 18 - 90

Code: NCT06529029·Phase 2, Phase 3

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Apathy-related Neurobehavioral Markers of Cognitive Decline in Old-age Bipolar Disorders: Proof-of-concept

for Apathy

Sponsor: Hospital Center Guillaume Régnier

Sex: All·Age: 70 - 85·Accepts healthy volunteers

Code: NCT06914284

Apply to this trial

Self-compassion and Bipolar Disorder

for Bipolar Disorder

Sponsor: University Hospital, Strasbourg, France

Sex: All·Age: 18+

Code: NCT06497868

Apply to this trial

Neurofeedback for Bipolar Disorder

for Bipolar Disorder

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18 - 65

Code: NCT05802446

Apply to this trial

Multisite rTMS for Mood, Cognitive Impairment and Other Symptoms of Depression

for Unipolar Depression

Sponsor: Jakub Antczak

Sex: All·Age: 18 - 65

Code: NCT06363981

Apply to this trial

Theta-Burst Stimulation for Bipolar Depression

for Bipolar Depression

Sponsor: Centre for Addiction and Mental Health

Sex: All·Age: 18 - 65

Code: NCT06370988

Apply to this trial

Effect of Intermittent and Continuous Theta Burst Stimulation on Sleep, Daytime Sleepiness, and Fatigue in Depression

for Unipolar Depression

Sponsor: Jakub Antczak

Sex: All·Age: 18 - 65

Code: NCT06371352

Apply to this trial

ACT for Syndromic and Subsyndromic Depression in Bipolar Disorder

for Bipolar Disorder

Sponsor: Beny Lafer

Sex: All·Age: 18 - 65

Code: NCT06365021

Apply to this trial

Honest Open Proud for Psychotic and Bipolar Disorder in Norway

for Psychotic Disorders

Sponsor: Oslo University Hospital

Sex: All·Age: 18 - 65

Code: NCT06384755

Apply to this trial

Enhanced Coordinated Specialty Care for Early Psychosis

for Psychosis

5 sites incl. Belmont

Sponsor: Mclean Hospital

Sex: All·Age: All ages

Code: NCT06071858

Apply to this trial

Use of Ketosis in Modulating Metabolic Pathways in Bipolar Disorder

for Bipolar Disorder

2 sites incl. Belmont

Sponsor: Stony Brook University

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT06373016

Apply to this trial

Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia, Bipolar Disorder or Autism Spectrum Disorder

for Schizophrenia

46 sites incl. Phoenix

Sponsor: Intra-Cellular Therapies, Inc.

Sex: All·Age: 5 - 17

Code: NCT06229210·Phase 3

Apply to this trial

Examining Neurobiological Mechanisms Underlying the Therapeutic Effect of the Ketogenic Diet in Bipolar Disorder (BD)

for Bipolar Disorder

1 site in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT06081426

Apply to this trial

Norwegian Adult Mental Health Registry

for Depression

Sponsor: Helse Stavanger HF

Sex: All·Age: 18+

Code: NCT06115200

Premorbid Personality Profile of Patients With Cognitive and Behavioral Disorders

for Behavioral Variant of Frontotemporal Disorder (bvFTD)

Sponsor: Nantes University Hospital

Sex: All·Age: 18+

Code: NCT06059313

Apply to this trial

NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder

for Bipolar Disorder

1 site in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 8 - 70·Accepts healthy volunteers

Code: NCT05669703

Apply to this trial

App and Body Fat Scale in the Management of Overweight Patients

for Schizophrenia

Sponsor: Capital Medical University

Sex: All·Age: 18 - 60

Code: NCT05866107

Apply to this trial

Cannabidiol for Bipolar Depression (CBD-BD)

for Bipolar Disorder

Sponsor: University of British Columbia

Sex: All·Age: 19 - 70

Code: NCT05867849·Phase 3

Apply to this trial

Bipolar disorder clinical trials — common questions

Are bipolar disorder clinical trials free to join?

Yes. Participating in a bipolar disorder clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a bipolar disorder clinical trial?

Each bipolar disorder study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a bipolar disorder trial near me?

Use the location controls above. We'll show recruiting bipolar disorder trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many bipolar disorder trials are recruiting right now?

We're currently tracking roughly 45 recruiting bipolar disorder trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Bipolar disorder trials by city

Boston, MA San Diego, CA Ann Arbor, MI Berkeley, CA Cleveland, OH Grand Rapids, MI La Jolla, CA Little Rock, AR Los Angeles, CA Orange, CA Palo Alto, CA

Related specialties

Psychiatry Mental health Behavioral health