Alternative Physical Activity Strategies for Breast Cancer Survivors

Sponsor
University of Toronto
Study ID
NCT06633380
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
FEMALE
Age
N/A - N/A
Healthy Volunteers
Accepted

Interventions

  • Standard Physical Activity - Fasted — BEHAVIORAL
    30 minutes of walking at a self-selected pace that they must have completed 15 minutes prior to consumption of first meal in the morning.
  • Standard Physical Activity - Post-Meal — BEHAVIORAL
    30 minutes of walking at a self-selected pace to start 30 minutes after the start of the first meal in the morning.
  • Dispersed Physical Activity — BEHAVIORAL
    10 minutes of walking at a self-selected pace to start 30 minutes after the start of each main meal throughout the day (i.e., three bouts total).
  • Physical Activity Snacks — BEHAVIORAL
    2 minutes of walking or marching on the spot at a self-selected pace every 30 minutes throughout the day for 7.5 waking hours.
  • Muscle Strengthening — BEHAVIORAL
    30 minutes of muscle strengthening exercises targeting the major muscle groups of the whole body, to start 30 minutes after the start of the first meal in the morning.

Study Details

The primary aim of this study is to compare the acute glycemic effects of two novel, alternative physical activity (PA) strategies (dispersed post-meal PA, PA snacks) to a no PA condition and to exercise sessions representing the PA guidelines (standard 30-minute walking bout performed under fasting and under postprandial conditions and a standard 30-minute resistance training session) among sedentary breast cancer survivors who are currently receiving hormone therapies and age- and BMI-matched postmenopausal women without a history of cancer. The secondary aim is to determine whether the alternative PA strategies are acceptable and feasible in the free-living setting. An exploratory aim is to determine whether the outcomes differ between women with and without a history of breast cancer and use of aromatase inhibitors. The investigators hypothesize that: 1. Dispersed PA and PA snacks will result in greater reductions in 24-hour glucose and postprandial glucose compared to the no-PA baseline and similar reductions to a standard 30-minute bouts of walking; 2. The alternative PA strategies will be more feasible and have greater acceptability by cancer survivors compared to the standard 30-minute bout of walking or resistance training; and 3. The different PA strategies will have similar effects on glycemic outcomes for both breast cancer survivors and cancer-free controls. The resistance exercise session is an exploratory trial as the effects of it on acute glycemic control are understudied.

Key Dates

First listed
Oct 9, 2024
Start date
Oct 22, 2024
Status verified
Nov 2025
Primary completion
Apr 30, 2026
Completion
Jul 1, 2026

Study Design

Enrollment
24 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION

Arms

  • Experimental: Standard Physical Activity - Fasted
    Participants will perform 30 minutes of walking at a self-selected pace 15 minutes prior to consumption of first meal in the morning (including cream/sugar/milk in coffee or tea).
  • Experimental: Standard Physical Activity - Post-Meal
    Participants will perform 30 minutes of walking at a self-selected pace 30 minutes after the start of the first meal in the morning.
  • Experimental: Dispersed Physical Activity
    Participants will perform 10 minutes of walking at a self-selected pace 30 minutes after the start of each main meal throughout the day (i.e., three bouts total).
  • Experimental: Physical Activity Snacks
    Participants will perform 2 minutes of walking or marching on the spot at a self-selected pace every 30 minutes throughout the day for 7.5 waking hours.
  • Experimental: Muscle Strengthening
    Participants will perform 30 minutes of muscle strengthening exercises targeting the major muscle groups of the whole body performed by following along with a video, to start 30 minutes after the start of the first meal in the morning.

Primary Outcome Measure

24-hour glucose incremental area under the curve (iAUC) [ Time Frame: Baseline, 24 hours of each intervention day ]

Central Contacts

Find similar trials

Nationwide
Breast cancer trialsOncology trialsBreast oncology trialsWomen's health trials

Related Studies