Peer-led Community-based PrEP Delivery Among Youth in Brazil

Sponsor
University of Alabama at Birmingham
Study ID
NCT06661356
Status
Not Yet Recruiting

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Conditions

  • HIV
  • Pre-Exposure Prophylaxis (PrEP)

Eligibility Criteria

Sex
ALL
Age
15 Years - 24 Years
Healthy Volunteers
Accepted

Interventions

  • COMPrEP — BEHAVIORAL
    Participants will be paired with peer lay workers and will meet with peer lay workers at private community location. They will discuss options for oral PrEP with peer lay workers and be provided provide daily oral PrEP or event-driven (2-1-1) PrEP. Participants will take part in rapid HIV testing at each visit. They will also meet with peer lay workers at private community location for follow-up at 1, 5, 9, and 13 months.

Study Details

The goal of this project is to conduct a series of studies to refine, test, and understand experiences with a peer-led community-based intervention in which youth will be integrated into health care teams and trained to deliver HIV pre-exposure prophylaxis (PrEP) to their peers. The study team will conduct a randomized trial to determine if peer delivery of PrEP to youth aged 15-24 in Brazil will increase PrEP uptake, persistence, and adherence compared to standard PrEP care provided in health facilities.

Key Dates

First listed
Oct 28, 2024
Start date
Oct 31, 2026
Status verified
Mar 2026
Primary completion
Aug 31, 2029
Completion
Aug 31, 2029

Study Design

Enrollment
1,400 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • No Intervention: Standard Care Arm
    Participants randomized to the standard care arm will receive PrEP at a health facility from a physician or nurse.
  • Experimental: COMPrEP Intervention
    Participants randomized to the COMPrEP intervention will receive PrEP from peer lay workers at private community locations.

Primary Outcome Measure

PrEP Uptake [ Time Frame: Within 1 month of enrollment ]

Central Contacts

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