Adebrelimab Combined With Irinotecan Liposomal (II), Oxaliplatin, and 5-FU/LV Conversion Therapy for Locally Advanced Pancreatic Cancer
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
- Study ID
- NCT06766019
- Phase
- PHASE2
- Status
- Active Not Recruiting
Conditions
Eligibility Criteria
- Sex
- ALL
- Age
- 18 Years - 70 Years
- Healthy Volunteers
- Not accepted
Interventions
- Adebrelimab combined with irinotecan liposomal (II), oxaliplatin, and 5-FU/LV — DRUG1. adebrelimab 1200mg, i.v. D1, q28d 2. irinotecan liposomal (II) 60mg/m\^2, i.v. D1, Q2W 3. oxaliplatin 85mg/m\^2, i.v. D1, Q2W 4. 5-FU/LV 2400mg/400mg/m\^2, i.v. D1, Q2W 4-week cycles, 6 cycles
Study Details
This trial is a prospective, single-arm, single-center, phase II clinical study, mainly targeting subjects with locally advanced pancreatic cancer, to explore the efficacy and safety of adebrelimab combined with irinotecan liposome (II), oxaliplatin, and 5-FU/LV conversion in the treatment of locally advanced pancreatic cancer.
Key Dates
- Start date
- Oct 16, 2024
- Status verified
- Jan 2025
- Primary completion
- Sep 30, 2027
- Completion
- Sep 30, 2027
Study Design
- Enrollment
- 47 participants (estimated)
- Allocation
- NA
- Intervention model
- SINGLE_GROUP
- Primary purpose
- TREATMENT
Arms
- Experimental: Adebrelimab combined with irinotecan liposomal (II), oxaliplatin, and 5-FU/LVAdebrelimab combined with irinotecan liposomal (II), oxaliplatin, and 5-FU/LV
Primary Outcome Measure
Surgical conversion rate [ Time Frame: Up to 6 months ]
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