A Study to Evaluate the Effect of Food on Nemtabrutinib (MK-1026) in Healthy Participants (MK-1026-017)

Part of paid clinical trials in Honolulu, Hawaii.

Sponsor
Merck Sharp & Dohme LLC
Study ID
NCT06772818
Phase
PHASE1
Status
Completed

Conditions

  • Healthy

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

Study Details

The goal of the study is to learn what happens to levels of nemtabrutinib in a healthy person's body over time. Researchers will compare what happens to nemtabrutinib in the body when it is given under fasted (on an empty stomach) and fed (after a high-fat meal) conditions.

Key Dates

Start date
Oct 2, 2023
Status verified
Jan 2025
Primary completion
Dec 20, 2023
Completion
Feb 16, 2024

Study Design

Enrollment
20 participants (actual)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Nemtabrutinib Treatment A
    Participants receive a single dose of nemtabrutinib on Day 1 under fasted conditions (on an empty stomach after a 10-hour overnight fast)
  • Experimental: Nemtabrutinib Treatment B
    Participants receive a single dose of nemtabrutinib on Day 1 under fed conditions (after a high-fat meal)

Primary Outcome Measure

Area under the concentration-time curve from time 0 extrapolated to infinity (AUC0-inf) of Nemtabrutinib [ Time Frame: Predose and at designated timepoints (up to approximately 2 weeks postdose) ]

Locations (1)

FacilityCityStateZIPSite coordinators
Labcorp Clinical Research Unit Inc. (Site 0001)HonoluluHawaii96813-

Find similar trials in Honolulu, HI

By research site
Labcorp Clinical Research Unit Inc.· Honolulu, HI

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