Effects os Physiotherapeutic Rehabilitation on Function Autonomic and Inflammatory in Patients With Long Covid

Sponsor
Universidade do Estado do Pará
Study ID
NCT07046208
Status
Not Yet Recruiting

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Conditions

  • Cardiac Biomarkers
  • Heart Rate Variability (HRV)
  • Inflammatory Biomarkers
  • Long COVID

Eligibility Criteria

Sex
ALL
Age
20 Years - 59 Years
Healthy Volunteers
Not accepted

Interventions

  • physiothreapy protocol — OTHER
    Aerobic training (treadmill or exercise bike) for 15 minutes, anaerobic training at the weight training station, performing exercises for the upper limbs (bench press and front pull) and lower limbs (180º leg press and extension chair) with weight determined by the 1 Repetition Maximum (1RM) test, performing 3 sets of 12-15 repetitions (depending on the session) and respiratory muscle training using POWERbreathe (30-40% of the MIP performed in the manovacuometry test).

Study Details

Introduction: Long COVID is characterized by persistent symptoms that persist for weeks or months after the acute phase of infection, with a significant impact on the cardiovascular and autonomic systems. Objectives: This study aims to evaluate the effects of a physiotherapeutic rehabilitation protocol on cardiovascular autonomic modulation and on inflammatory and cardiac biomarkers in patients with Long COVID. Methodology: This is a controlled clinical trial, carried out in a cardiorespiratory rehabilitation outpatient clinic, involving individuals with a clinical diagnosis of Long COVID undergoing a protocol of 20 aerobic, anaerobic and respiratory rehabilitation sessions. Heart rate variability (HRV) variables will be analyzed using linear and non-linear methods, in addition to serum levels of CKMB, LDH, ferritin and C-reactive protein. Expected results: Rehabilitation is expected to provide an improvement in autonomic function and a reduction in inflammatory and cardiac markers, contributing to the understanding of the pathophysiological mechanisms of Long COVID and helping to propose evidence-based therapeutic strategies.

Key Dates

First listed
Jul 1, 2025
Start date
Aug 11, 2025
Status verified
Jun 2025
Primary completion
Aug 10, 2026
Completion
Sep 30, 2026

Study Design

Enrollment
58 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE

Arms

  • Experimental: Rehabilitation for long covid
    Physioterapy protocol

Primary Outcome Measure

Autonomic Modulation [ Time Frame: Before and afther the intervention 3 months. ]

Central Contacts

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