Implementation of a Joint Pulmonologist and ENT Consultation in the Care Pathway of Patients Suffering From Asthma and Chronic Rhinosinusitis With Nasal Polyposis: Effectiveness Compared With Consultations by Specialty (CON-PO Study).

Sponsor
Assistance Publique Hopitaux De Marseille
Study ID
NCT07134686
Status
Recruiting
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Conditions

  • Asthma
  • Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Joint consultation — OTHER
    Joint consultation with pneumologist and ENT at baseline.
  • Mucus sampling — PROCEDURE
    Mucus sampling at baseline and one year follow-up
  • Nasal brushing — PROCEDURE
    Nasal brushing at baseline and one year follow-up

Study Details

Asthma affects the lower respiratory tract (bronchi), whereas chronic rhinosinusitis with nasal polyposis (CRSwNP) involves the upper airways. Despite this anatomical distinction, the upper and lower airways form a continuous respiratory tract and share common pathophysiological mechanisms. Consequently, asthma and CRSwNP frequently coexist, and several therapeutic strategies are effective for both conditions. Given these overlaps, we hypothesize that a multidisciplinary consultation involving both a pulmonologist and an ENT specialist could be more effective than separate consultations for patient care. We also believe that this innovative organization that would benefit the healthcare system. To test this hypothesis, we are conducting a study whose primary objective is to assess whether joint consultations lead to a reduction in oral corticosteroid need over the year following the initial consultation, by enabling more personalized treatment strategies. Secondary outcomes will include the frequency of asthma exacerbations, frequency of ENT-related events, respiratory symptoms, quality of life, and healthcare ressources utilization. We will compare outcomes between two patient groups: one receiving joint consultation from both specialists, and the other managed through standard, separate consultations as per current clinical practice.

Key Dates

First listed
Aug 21, 2025
Start date
Jul 28, 2026
Status verified
Jul 2026
Primary completion
Nov 30, 2029
Completion
Nov 30, 2029

Study Design

Enrollment
195 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Experimental: Joint consultation
    Multi-disciplinary consultation with a pulmonologist and ENT specialist at the baseline visit
  • Active Comparator: Separate consultations
    Separate consultations with a pulmonologist and ENT specialist at the baseline visit as standard care

Primary Outcome Measure

Effectiveness of joint ENT and pulmonologist consultation on relative change in cumulative annual dose of oral corticosteroids from the year before Baseline to the year between Baseline and 12 months visit. [ Time Frame: From the year before Baseline to the 12 months visit. ]

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