Carcinogen and Toxicant Exposure Among Young Adults Who Co-Use Cigarettes, E-cigarettes and Cannabis (Co-Tox Study)

Conditions

• Cigarette Smoking-Related Carcinoma
• E-Cig Use

Eligibility Criteria

Sex

ALL

Age

18 Years - 25 Years

Healthy Volunteers

Accepted

Interventions

• Effectiveness of different recruitment approaches — OTHER
  Subjects will asked which type of recruitment material they've seen when completing the screening survey
• Choice of study completion locations — OTHER
  subjects will choose location when coordinator calls to schedule appointment
• Cannabis Engagement Assessment — OTHER
  Self reported measure of current cannabis use that contains 30 questions assessing quantity, frequency of use and method of consumption in the past 30 days.
• E-cigarette dependence Scale — OTHER
  A 22-item questionnaire measuring e-cigarette dependence. Higher scores indicate greater dependence.
• Nicotine dependence Scale — OTHER
  Self reported measure of current nicotine use that contains 27 questions assessing quantity, frequency of use in past 6 months
• Co use practices QUestionnaire — OTHER
  Self reported measure of nicotine and cannabis use that contains 25 questions assessing quantity, frequency and practices of use in past 30 days

Study Details

This study evaluates the amount of nicotine, cannabis, and toxicants linked to the use of nicotine e-cigarette and/or cannabis products in the blood and urine of young adult users as well as the cannabis and nicotine use behaviors of consumers.

Key Dates

First listed

Sep 11, 2025

Start date

Apr 3, 2025

Status verified

Aug 2026

Primary completion

Oct 1, 2028

Completion

Oct 1, 2028

Study Design

Enrollment

150 participants (estimated)

Arms

• Arm: E-cigarette consumers
  Predominant e-cigarette consumers
• Arm: Cannabis consumers
  Predominant cannabis consumers
• Arm: e-cigarette -cannabis coconsumers
  Consumers who use both e-cigarettes and cannabis .
• Arm: Cigarette coconsumers
  Predominant cigarette consumer
• Arm: Cigarette-cannabis coconsumer
  Consumers who use both Cigarette and cannabis

Primary Outcome Measure

Differences in biomarker levels across groups [ Time Frame: 1 study session lasting 1 hour ]

Central Contacts

• ASK RPCI
  1-800-767-9355
  [email protected]

Locations (1)

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