Timing of Opioid Administration and Postoperative Respiratory Depression.

Conditions

• Opioid Induced Respiratory Depression
• Postoperative Respiratory Complications
• Respiratory Complications

Eligibility Criteria

Sex

ALL

Age

18 Years - 85 Years

Healthy Volunteers

Accepted

Interventions

• Respiratory volume monitoring — DIAGNOSTIC_TEST
  Noninvasive continuous respiratory monitoring utilizing bio-impedance to detect tidal volumes, respiratory rate, and minute ventilation.

Study Details

The goal of this study is to determine if a relationship can be detected between the administration of an opioid and quantitative respiratory depression in spontaneously breathing non-intubated patients who have undergone general anesthesia and have received perioperative opioids. The primary aim is to determine the temporal effect of opioid administration on respiratory depression as assessed by minute ventilation with a reduction of at least 20% in the percent of predicted minute ventilation. A secondary aim is to determine a dose response of opioid administration and its effect on minute ventilation. The investigators aim to determine the influence of opioid administration on minute ventilation on spontaneously breathing patients during post-anesthesia care unit (PACU) stay.

Key Dates

First listed

Nov 12, 2025

Start date

Feb 1, 2026

Status verified

Jul 2026

Primary completion

Dec 1, 2028

Completion

Feb 1, 2029

Study Design

Enrollment

52 participants (estimated)

Arms

• Arm: Study group
  Patients receiving general anesthesia with an expected anesthetic time of at least 2 hours

Primary Outcome Measure

Respiratory interventions 1 [ Time Frame: Within 4 hours of patient admittance to Post Anesthetic Care Unit (PACU) ]

Central Contacts

• George M McKelvey, PhD
  3135986036
  [email protected]

Locations (1)

Find similar trials in Detroit, MI

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  Enrolling By Invitation · Naval Medical Center Camp Lejeune · Marine Corps Base Camp Lejeune, North Carolina