Giving Asthmatics Intramuscular Steroids for Preventing Return to the Emergency Department

Part of paid clinical trials in The Bronx, New York.

Sponsor: Montefiore Medical Center
Study ID: NCT07228052
Phase: PHASE4
Status: Recruiting

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Conditions

Asthma

Eligibility Criteria

Sex: ALL
Age: 18 Years - N/A
Healthy Volunteers: Not accepted

Interventions

Dexamethasone 16mg IM — DRUG
Dexamethasone 16mg Intramuscular Administration Once
Prednisone 60mg PO — DRUG
Prednisone 60mg PO for 5 Days

Study Details

This study aims to compare the efficacy of a one-time IM dose of dexamethasone versus a 5-day course of prednisone in adult ED patients presenting with asthma exacerbations. This is a randomized, controlled, double-blind, non-inferiority trial conducted at two urban EDs within the Montefiore Health System.

Key Dates

First listed: Nov 13, 2025
Start date: Jul 23, 2026
Status verified: Jul 2026
Primary completion: Dec 31, 2026
Completion: Dec 31, 2026

Study Design

Enrollment: 182 participants (estimated)
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Arms

Active Comparator: Single Intramuscular Steroid Injection
Dexamethasone 16mg Intramuscular Single Dose
Active Comparator: Oral Steroid Short Course
Prednisone 60mg PO for 5 Days