Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)

Part of paid clinical trials in Los Angeles, California.

Sponsor
Revolution Medicines, Inc.
Study ID
NCT07252232
Phase
PHASE3
Status
Recruiting
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Conditions

  • PDAC
  • PDAC - Pancreatic Ductal Adenocarcinoma
  • Pancreatic Cancer
  • Resectable Pancreatic Ductal Adenocarcinoma (PDAC)
  • Resected Pancreatic Adenocarcinoma

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

The purpose of this study is to evaluate the safety and efficacy of a novel RAS(ON) inhibitor compared to standard of care (SOC) observation only.

Key Dates

First listed
Nov 26, 2025
Start date
Dec 15, 2025
Status verified
Jun 2026
Primary completion
May 10, 2029
Completion
Jul 10, 2030

Study Design

Enrollment
500 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: daraxonrasib
    study drug
  • No Intervention: SOC Observation
    Patients randomized to the comparator control arm will receive SOC observation.

Primary Outcome Measure

Disease-Free Survival (DFS) per Investigator [ Time Frame: Up to approximately 5 years ]

Central Contacts

Locations (29)

FacilityCityStateZIPSite coordinators
Cedars-Sinai Cancer at Cedars-Sinai Medical CenterLos AngelesCalifornia90048
Naomi Geier
[email protected]
310-423-4693
University of California, Los AngelesLos AngelesCalifornia90404
Madeleine Manahan
[email protected]
310-633-8400
Stanford Cancer InstitutePalo AltoCalifornia94304
Cassandra Blake
[email protected]
650-725-9895
University of California, San FranciscoSan FranciscoCalifornia94143
Kevin Lopez
[email protected]
415-502-3310
Rocky Mountain Cancer Centers, LLPLakewoodColorado80228-
Hartford HealthcareHartfordConnecticut06103
Jonathan Steinmetz
[email protected]
860-972-4183
Mayo ClinicJacksonvilleFlorida32224
Hani Babiker
[email protected]
520-626-7866
University of Miami Hospital and Clinics, Sylvester Comprehensive Cancer CenterMiamiFlorida33136
Yolanda Justal
[email protected]
305-243-2647
Winship Cancer Institute, Emory UniversityAtlantaGeorgia30322
Kathleen Coleman
[email protected]
404-251-1278
Community Health NetworkIndianapolisIndiana46250
Adam Norris
[email protected]
317-621-3858
University of Kansas Medical Center Research Institute, Inc.LawrenceKansas66045-
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins & Sibley Memorial HospitalBaltimoreMaryland21287
GI Clinical Trial Referrals
[email protected]
410-614-3644
Mike Pishvaian
202-660-6500
Dana Farber Cancer Institute (DFCI)BostonMassachusetts02215
617-632-3000
Massachusetts General HospitalBostonMassachusetts02114-
Mayo Clinic Cancer CenterRochesterMinnesota55905
Ryan Carr
[email protected]
507-284-2511
Saint Luke's Cancer InstituteKansas CityMissouri64111
Marc Roth
[email protected]
816-932-2677
University of Nebraska Medical CenterOmahaNebraska68198-
Comprehensive Cancer Centers of NevadaLas VegasNevada89169
Ann Lovelace
[email protected]
702-609-9460
Columbia University Medical CenterNew YorkNew York10032
Laura and Issac Perlmutter Cancer Center at NYU Langone-Ambulatory Care CenterNew YorkNew York10016
Mark Bond
[email protected]
212-731-6120
Jennifer Coffey
[email protected]
212-731-6120
Memorial Sloan Kettering Cancer CenterNew YorkNew York10065
Eileen O'Reilly
[email protected]
646-888-4182
Duke Cancer CenterDurhamNorth Carolina27710-
Taylor Cancer Research CenterMaumeeOhio43537
Stephanie Ambrose
[email protected]
567-402-4502
Avera Cancer InstituteSioux FallsSouth Dakota57105
Heidi McKean
[email protected]
605-322-6900
SCRI Oncology PartnersNashvilleTennessee37203-
Texas Oncology - DFWDallasTexas75246-
Texas Oncology - Northeast TexasLongviewTexas75601
University of Utah, Huntsman Cancer InstituteSalt Lake CityUtah94112
Susan Sherry
[email protected]
801-585-3453
Virginia Cancer SpecialistsFairfaxVirginia22031-

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