Surgical Versus Percutaneous Revascularization in Patients With Reduced Left Ventricular Function (STICH 3.0-NL)

Sponsor
University Medical Center Groningen
Study ID
NCT07269366
Status
Recruiting
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Conditions

  • CABG
  • CABG in Low EF
  • Coronary Artery Disease
  • Coronary Artery Disease (CAD)
  • Heart Failure
  • Multivessel Coronary Artery Disease
  • PCI
  • Revascularization

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • CABG — PROCEDURE
    CABG (coronary artery bypass grafting)
  • PCI — PROCEDURE
    PCI (percutaneous coronary intervention)

Study Details

This randomized multicenter trial compares coronary artery bypass grafting (CABG) with percutaneous coronary intervention (PCI) in 358 patients with ischemic left ventricular dysfunction and multivessel coronary disease. The study evaluates differences in survival, major cardiovascular events, and quality of life over 4 years, and contributes to the international STICH 3.0 collaboration assessing long-term outcomes.

Key Dates

First listed
Dec 8, 2025
Start date
May 31, 2026
Status verified
May 2026
Primary completion
May 31, 2034
Completion
May 31, 2034

Study Design

Enrollment
358 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: CABG (surgery)
    Patients randomized to CABG will receive CABG - aiming for full revascularization
  • Other: PCI (percutaneous)
    Patients randomized to PCI will receive PCI - aiming for full revascularization

Primary Outcome Measure

Hierarchical composite of all-cause mortality, major adverse cardiovascular events, and heart failure hospitalizations [ Time Frame: 4 years ]

Central Contacts

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