Heart failure Clinical Trials

Recruiting heart failure studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat heart failure. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting heart failure studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting heart failure trials

Within

Real-world Study to Describe the Effectiveness and Safety Outcomes of Jardiance in Chinese Patients With Heart Failure and Preserved Ejection Fraction

for Heart Failure

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT07047508

A Study of the Effect of a Nurse Navigator Program on High Risk Patients

for Patient Readmission

1 site in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05592847

Biventricular Remodeling in Transcatheter Tricuspid Valve Replacement - Acute Hemodynamic Instability Study

for Tricuspid Regurgitation

1 site in New York

Sponsor: Columbia University

Sex: All·Age: 18+

Code: NCT06954792

Feasibility and Acceptability of Three Component Intervention for the Heart Failure Care for Rural Dwelling Participants

for Heart Failure

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18+

Code: NCT07103239

Safety and Efficacy of Low-dose Anticoagulation With Argatroban and Enoxaparin on ECMO

for Pneumonia

Sponsor: University Hospital Ostrava

Sex: All·Age: 18+

Code: NCT07499037·Phase 2

Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)

for Obesity and Obesity-related Medical Conditions

1 site in Columbia

Sponsor: Bettina Mittendorfer

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT07083557

Apply to this trial

Relaxin Therapy for Atrial Fibrillation

for Atrial Fibrillation (AF)

Sponsor: Deeptankar DeMazumder

Sex: All·Age: 18+

Code: NCT07359872·Phase 1, Phase 2

Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress

for Critical Illness

3 sites incl. Los Angeles

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07634419

PAtient Similarity for Decision-Making in Prevention of Cardiovascular Toxicity (PACT): A Feasibility Study

for Heart Failure

1 site in Milwaukee

Sponsor: Medical College of Wisconsin

Sex: All·Age: 18+

Code: NCT05377320

Pulmonary Artery Denervation for Heart Failure With Preserved Left Ventricular Ejection Fraction

for Heart Failure With Preserved Ejection Fraction

Sponsor: Nanjing First Hospital, Nanjing Medical University

Sex: All·Age: 18 - 85

Code: NCT07331220

PCI With GDMT Versus GDMT Alone for Patients With Ischemic Cardiomyopathy and Reduced LVEF

for Heart Failure With Reduced Ejection Fraction

Sponsor: Nanjing First Hospital, Nanjing Medical University

Sex: All·Age: 18+

Code: NCT07349979

Data-Driven Phenotyping in Heart Failure With Preserved Ejection Fraction

for Heart Failure

Sponsor: Instituto Politécnico de Leiria

Sex: All·Age: 18+

Code: NCT07429396

CGM Use in Heart Failure

for Heart Failure

1 site in Atlanta

Sponsor: Emory University

Sex: All·Age: 18 - 90

Code: NCT07045298

Remote Monitoring and Optimization of Heart Failure Therapy

for Heart Failure

Sponsor: Zoll Medical Corporation

Sex: All·Age: 18 - 85

Code: NCT07622472

LEFT ATRIAL MONITORING IN PATIENTS BEFORE AND AFTER MITRAL SURGERY - LAMBDA STUDY

for Mitral Regurgitation

Sponsor: Ottawa Heart Institute Research Corporation

Sex: All·Age: 18+

Code: NCT06547788

Bedside Assessment of Right Ventricular Output Lying in Prone Or Supine Position

for Right Ventricular Function

Sponsor: Sahlgrenska University Hospital

Sex: All·Age: 18+

Code: NCT07632027

DIALOZIC - Pilot Study of a Diagnostic Pathway for Heart Failure in Rural Areas: the Contribution of Telebiology and Telemedicine

for Heart Failure

Sponsor: University Hospital, Montpellier

Sex: All·Age: 60+

Code: NCT07682545

N-of-1 Trial to Promote Beta-Blocker Titration in Heart Failure

for Heart Failure

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 60+

Code: NCT07489352

OPtimizing Aldosterone Receptor Antagonist Therapy by Sodium Zirconium Cyclosili-cate in Heart Failure -Extension (OPRA-HF Extension)

for Heart Failure

Sponsor: Sahlgrenska University Hospital

Sex: All·Age: 70+

Code: NCT07576257·Phase 2

Outpatient Hypertonic Saline and Loop Diuretic Combination Therapy in Cardiorenal

for Heart Failure

Sponsor: University of Monastir

Sex: All·Age: 18 - 90

Code: NCT07596329·Phase 3

Structured Cardio-Oncology Rehabilitation for Cardiovascular Outcomes in Cancer Survivors

for Cancer Therapy-Related Cardiac Dysfunction

Sponsor: Xinjiang Medical University

Sex: All·Age: 18 Months+

Code: NCT07622394

eHealth Lifestyle Intervention To Enhance Outcomes in HFpEF

for Heart Failure and Preserved Ejection Fraction

Sponsor: Maimónides Biomedical Research Institute of Córdoba

Sex: All·Age: 18+

Code: NCT07661732

Evaluation of a French Hospital Discharge Therapeutic Education Program by Nurses for Heart Failure Patient (EduSor)

for Heart Failure

Sponsor: University Hospital, Clermont-Ferrand

Sex: All·Age: 18+

Code: NCT07706543

A Prospective, Randomized Multicenter Clinical Trial of the TricValve® Transcatheter Bicaval Valve System in Subjects With Severe Tricuspid Regurgitation.

for Tricuspid Valve Disease

35 sites incl. Birmingham

Sponsor: P+F Products + Features USA Inc.

Sex: All·Age: 18 - 85

Code: NCT06458907

Early Discharge With Subcutaneous Furosemide Versus Standard Care in Acute Heart Failure

for Heart Failure

2 sites in Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 100

Code: NCT07018297·Phase 3

Advancing Clinical Heart Failure Outcomes Leveraging Defibrillation Lead Implant System for Left Bundle Branch Area Pacing

for Heart Failure

Sponsor: Medtronic Cardiac Rhythm and Heart Failure

Sex: All·Age: 18+

Code: NCT07526896

A Study of LY3971297 in Participants With Heart Failure

for Heart Failure

3 sites incl. Detroit

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 65

Code: NCT07547540·Phase 1

Heart Failure and Postoperative Outcome in Surgery - a National Registry Study

for Heart Failure

Sponsor: Umeå University

Sex: All·Age: 18+

Code: NCT07634822

IV Iron Therapy for Older Adults With Heart Failure With Preserved Ejection Fraction and Iron Deficiency

for Heart Failure With Preserved Ejection Fraction

1 site in Durham

Sponsor: Duke University

Sex: All·Age: 65+

Code: NCT07686692·Phase 4

Arterial Stiffness and Endothelial Function in Heart Failure

for Heart Failure

Sponsor: Coventry University

Sex: All·Age: 18 - 90

Code: NCT07713719

The Value of a Simple Tool for the Early Detection of Decompensated Heart Failure in People Over 55 on Réunion Island: A Preliminary Study in Hospitals (DEPIST'IC-RUN)

for Heart Failure

Sponsor: Centre Hospitalier Universitaire de la Réunion

Sex: All·Age: 55+

Code: NCT07673562

Novel Model of Integrated Care of Older Patients With Atrial Fibrillation to Prevent Heart Failure in Rural China

for Atrial Fibrillation

Sponsor: Jiangsu Taizhou People's Hospital

Sex: All·Age: 65 - 80

Code: NCT07492498

Apply to this trial

Novel Model of Integrated Care of Older Patients With Atrial Fibrillation and Heart Failure in Rural China (MIRACLE-AFHF)

for Atrial Fibrillation

Sponsor: Jiangsu Taizhou People's Hospital

Sex: All·Age: 65 - 80

Code: NCT07492524

Apply to this trial

Wearable Assessment of Thoracic, Cardiac Health and Exercise Performance Trial Prospective

for Congenital Heart Disease

Sponsor: The University of Hong Kong

Sex: All·Age: 20 - 70

Code: NCT07663799

Prospective Cohort of Acute Cardiology Referrals in an Ambulatory Day-Hospital Setting

for Acute Coronary Syndromes

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18+

Code: NCT07675434

Virtual Nurse and Social Worker Palliative Care Team to Improve Quality of Life in Veterans With Heart Failure or COPD

for Heart Failure

7 sites incl. Phoenix

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07714252

Neprilysin Inhibition to Reduce Myocardial Fibrosis in Heart Failure With Preserved Ejection Fraction

for Heart Failure With Preserved Ejection Fraction

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 50 - 85

Code: NCT06536309·Phase 4

CASTLE-HFpEF (Catheter Ablation for Atrial Fibrillation Patients With Heart Failure With Mildly Reduced and Preserved Ejection Fraction)

for Atrial Fibrillation

Sponsor: Tulane University

Sex: All·Age: 18 - 120

Code: NCT07254455

Exercise Cardiovascular Magnetic Resonance In Heart Failure With Preserved Ejection Fraction

for Heart Failure With Preserved Ejection Fraction

1 site in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07401771

Apply to this trial

Heart Failure Efficacy and Research Trial (HEART) Platform

for Heart Failure

Sponsor: University of Alberta

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07428135

Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score

for Heart Failure With Reduced Ejection Fraction

1 site in Ann Arbor

Sponsor: University of Michigan

Sex: All·Age: 18+

Code: NCT07490067·Phase 4

Apply to this trial

AV Nodal Ablation With Conduction System Pacing Versus Cardiac Resynchronization for Symptomatic Heart Failure Patients With Atrial Fibrillation

for Atrial Fibrillation (AF)

Sponsor: University Medical Center Groningen

Sex: All·Age: 18+

Code: NCT07604727

Moderate Intensity vs High Intensity Interval Training in Women With Heart Failure

for Heart Failure

Sponsor: Riphah International University

Sex: Female·Age: 40 - 70

Code: NCT07662876

A Study of Metformin to Improve Cardiac Function After LVAD Implantation

for Heart Failure

Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

Sex: All·Age: 18 - 75

Code: NCT07666698·Phase 1, Phase 2

Explainable AI for Predicting Hospital Admissions in Heart Failure: ExplAIn-HF

for Heart Failure

Sponsor: Medisch Spectrum Twente

Sex: All·Age: 18+

Code: NCT07689760

Lumacaftor Yields Reversal of Impaired Cerebral Blood Flow in Heart Failure Patients

for Heart Failure With Reduced Ejection Fraction

Sponsor: Qanatpharma AG

Sex: All·Age: 18+

Code: NCT07695090·Phase 2

Apply to this trial

A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease

for Pulmonary Hypertension

3 sites incl. Houma

Sponsor: Pulnovo Medical, Inc.

Sex: All·Age: 18 - 85

Code: NCT07214376

Apply to this trial

Multi-Scale Analysis of Phenotypes in Heart Failure (MAP-HEART)

for Heart Failure

1 site in Falls Church

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 18 - 100

Code: NCT06280820

SUPPORT-HEART-PK: Effectiveness, Implementation, and Economic Evaluation of Implementation, and Theory-Based Digital Self-Management Intervention for Heart Failure Management

for Heart Failure

Sponsor: Universiti Putra Malaysia

Sex: All·Age: 18+

Code: NCT07580508

Pharmacist-Assisted Titration of Rx to Implement Optimal Medical Therapy for Heart Failure

for Heart Failure

1 site in Aurora

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07714239

CSP #2025 - Geriatric OUt-of-hospital Randomized MEal Trial in Heart Failure: Veterans Affairs (GOURMET-VA)

for Heart Failure

1 site in Ann Arbor

Sponsor: VA Office of Research and Development

Sex: All·Age: 60+

Code: NCT05996328

Prospective Evaluation of Artificial Intelligence-enabled Screening for Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

for ATTR Amyloidosis With Cardiomyopathy

1 site in New Haven

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT07398950

Promoting Palliative Care for People With Heart Failure

for Heart Failure

2 sites in New Haven

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT06933875

Apply to this trial

Improving TRansitions ANd OutcomeS for Heart FailurE Patients in Home Health CaRe (I-TRANSFER-HF)

for Heart Failure

2 sites in New York

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06118983

Apply to this trial

A Multi-site, Prospective, Non-interventional, Observational Data Collection Study in Patients Undergoing a Right Heart Catheterization

for Heart Failure

Sponsor: Acorai AB

Sex: All·Age: 18+

Code: NCT07010562

CORTISHOCK-P: Trial of Corticosteroids in Inflammation-Enriched Heart Failure Cardiogenic Shock

for Cardiogenic Shock

1 site in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 80

Code: NCT07461961·Phase 2

STRATegy SUccesS in High-Risk PCI With Impella CP: Evaluation of Hemodynamic Protection in Complex PCI

for Coronary Artery Disease

Sponsor: Rayyan Hemetsberger

Sex: All·Age: 18+

Code: NCT07588399

Effect of Dapagliflozin on Right Ventricular-Pulmonary Artery Coupling After Off-Pump Coronary Atery Bypass Grafting

for Heart Failure

Sponsor: Pyatigorsk City Clinical Hospital Number 1

Sex: All·Age: 18+

Code: NCT07601867

Apply to this trial

In-Hospital Wearable-Based Monitoring Versus Standard Care in Cardiovascular Disease (INSPIRE)

for Cardiovascular Diseases

Sponsor: Yonsei University

Sex: All·Age: 20+

Code: NCT07622485

Sacubitril-valsartan in Patients With Heart Failure With Reduced Ejection Fraction From Rural Tanzania

for Heart Failure

Sponsor: Martin Rohacek

Sex: All·Age: 18+

Code: NCT06704633·Phase 4

Apply to this trial

Heart failure clinical trials — common questions

Are heart failure clinical trials free to join?

Yes. Participating in a heart failure clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a heart failure clinical trial?

Each heart failure study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a heart failure trial near me?

Use the location controls above. We'll show recruiting heart failure trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many heart failure trials are recruiting right now?

We're currently tracking roughly 274 recruiting heart failure trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Heart failure trials by city

Boston, MA Birmingham, AL Los Angeles, CA Chicago, IL Cleveland, OH Detroit, MI Palo Alto, CA Ann Arbor, MI Stanford, CA Columbus, OH Gainesville, FL Salt Lake City, UT

Related specialties

Cardiology Heart disease