Heart failure Clinical Trials

Recruiting heart failure studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat heart failure. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting heart failure studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting heart failure trials

Within

Real-world Study to Describe the Effectiveness and Safety Outcomes of Jardiance in Chinese Patients With Heart Failure and Preserved Ejection Fraction

for Heart Failure

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT07047508

A Study of the Effect of a Nurse Navigator Program on High Risk Patients

for Patient Readmission

1 site in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05592847

Biventricular Remodeling in Transcatheter Tricuspid Valve Replacement - Acute Hemodynamic Instability Study

for Tricuspid Regurgitation

1 site in New York

Sponsor: Columbia University

Sex: All·Age: 18+

Code: NCT06954792

Feasibility and Acceptability of Three Component Intervention for the Heart Failure Care for Rural Dwelling Participants

for Heart Failure

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18+

Code: NCT07103239

Safety and Efficacy of Low-dose Anticoagulation With Argatroban and Enoxaparin on ECMO

for Pneumonia

Sponsor: University Hospital Ostrava

Sex: All·Age: 18+

Code: NCT07499037·Phase 2

Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)

for Obesity and Obesity-related Medical Conditions

1 site in Columbia

Sponsor: Bettina Mittendorfer

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT07083557

Apply to this trial

Relaxin Therapy for Atrial Fibrillation

for Atrial Fibrillation (AF)

Sponsor: Deeptankar DeMazumder

Sex: All·Age: 18+

Code: NCT07359872·Phase 1, Phase 2

Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress

for Critical Illness

3 sites incl. Los Angeles

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07634419

GLP-1/GIP Receptor Agonists in Obesity-Related HFpEF: The GLIDE-HF Registry

for Heart Failure With Preserved Ejection Fraction

Sponsor: Miedziowe Centrum Zdrowia SA

Sex: All·Age: 18+

Code: NCT07787936

PAtient Similarity for Decision-Making in Prevention of Cardiovascular Toxicity (PACT): A Feasibility Study

for Heart Failure

1 site in Milwaukee

Sponsor: Medical College of Wisconsin

Sex: All·Age: 18+

Code: NCT05377320

Pulmonary Artery Denervation for Heart Failure With Preserved Left Ventricular Ejection Fraction

for Heart Failure With Preserved Ejection Fraction

Sponsor: Nanjing First Hospital, Nanjing Medical University

Sex: All·Age: 18 - 85

Code: NCT07331220

PCI With GDMT Versus GDMT Alone for Patients With Ischemic Cardiomyopathy and Reduced LVEF

for Heart Failure With Reduced Ejection Fraction

Sponsor: Nanjing First Hospital, Nanjing Medical University

Sex: All·Age: 18+

Code: NCT07349979

Data-Driven Phenotyping in Heart Failure With Preserved Ejection Fraction

for Heart Failure

Sponsor: Instituto Politécnico de Leiria

Sex: All·Age: 18+

Code: NCT07429396

CGM Use in Heart Failure

for Heart Failure

1 site in Atlanta

Sponsor: Emory University

Sex: All·Age: 18 - 90

Code: NCT07045298

Exercise Cardiovascular Magnetic Resonance In Heart Failure With Preserved Ejection Fraction

for Heart Failure With Preserved Ejection Fraction

1 site in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07401771

Apply to this trial

Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score

for Heart Failure With Reduced Ejection Fraction

1 site in Ann Arbor

Sponsor: University of Michigan

Sex: All·Age: 18+

Code: NCT07490067·Phase 4

Apply to this trial

ACetazolamide in Patients With Heart Failure, to Decrease Weight and relIEVE Symptoms.

for Heart Failure

Sponsor: University Hospital, Montpellier

Sex: All·Age: 18+

Code: NCT07737964·Phase 3

Discontinuation or Continuation of SGLT-2 Inhibitors Before Cardiac Surgery

for Heart Failure

Sponsor: University Hospital, Toulouse

Sex: All·Age: 18+

Code: NCT07766109·Phase 4

Right Ventricular Septal Biopsy to Detect Cardiac Amyloidosis

for ATTR-CM (Transthyretin Amyloid Cardiomyopathy)

Sponsor: Geisinger Clinic

Sex: All·Age: 50 - 105

Code: NCT07784712

Integrating Values Based Communication in Heart Failure Management

for Heart Failure

1 site in Louisville

Sponsor: Abigail Latimer

Sex: All·Age: 18 - 105

Code: NCT07794930

CORTISHOCK-P: Trial of Corticosteroids in Inflammation-Enriched Heart Failure Cardiogenic Shock

for Cardiogenic Shock

1 site in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 80

Code: NCT07461961·Phase 2

Remote Monitoring and Optimization of Heart Failure Therapy

for Heart Failure

Sponsor: Zoll Medical Corporation

Sex: All·Age: 18 - 85

Code: NCT07622472

LEFT ATRIAL MONITORING IN PATIENTS BEFORE AND AFTER MITRAL SURGERY - LAMBDA STUDY

for Mitral Regurgitation

Sponsor: Ottawa Heart Institute Research Corporation

Sex: All·Age: 18+

Code: NCT06547788

Bedside Assessment of Right Ventricular Output Lying in Prone Or Supine Position

for Right Ventricular Function

Sponsor: Sahlgrenska University Hospital

Sex: All·Age: 18+

Code: NCT07632027

DIALOZIC - Pilot Study of a Diagnostic Pathway for Heart Failure in Rural Areas: the Contribution of Telebiology and Telemedicine

for Heart Failure

Sponsor: University Hospital, Montpellier

Sex: All·Age: 60+

Code: NCT07682545

Intrahospital Influenza Vaccination in Patients at High Cardiovascular Risk (VACC-UP)

for Acute Coronary Syndrome

Sponsor: Stephan Baldus

Sex: All·Age: 18+

Code: NCT07721649

Heart Failure Self Care Education in Rwanda

for Heart Failure

Sponsor: Boston Medical Center

Sex: All·Age: 10+

Code: NCT07722468

Multi-Scale Analysis of Phenotypes in Heart Failure (MAP-HEART)

for Heart Failure

2 sites incl. Baltimore

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 18 - 100

Code: NCT06280820

OPtimizing Aldosterone Receptor Antagonist Therapy by Sodium Zirconium Cyclosili-cate in Heart Failure -Extension (OPRA-HF Extension)

for Heart Failure

Sponsor: Sahlgrenska University Hospital

Sex: All·Age: 70+

Code: NCT07576257·Phase 2

Outpatient Hypertonic Saline and Loop Diuretic Combination Therapy in Cardiorenal

for Heart Failure

Sponsor: University of Monastir

Sex: All·Age: 18 - 90

Code: NCT07596329·Phase 3

Structured Cardio-Oncology Rehabilitation for Cardiovascular Outcomes in Cancer Survivors

for Cancer Therapy-Related Cardiac Dysfunction

Sponsor: Xinjiang Medical University

Sex: All·Age: 18 Months+

Code: NCT07622394

eHealth Lifestyle Intervention To Enhance Outcomes in HFpEF

for Heart Failure and Preserved Ejection Fraction

Sponsor: Maimónides Biomedical Research Institute of Córdoba

Sex: All·Age: 18+

Code: NCT07661732

Evaluation of a French Hospital Discharge Therapeutic Education Program by Nurses for Heart Failure Patient (EduSor)

for Heart Failure

Sponsor: University Hospital, Clermont-Ferrand

Sex: All·Age: 18+

Code: NCT07706543

High-Protein Diet and HMB Supplementation in Patients With Heart Failure

for Heart Failure

Sponsor: Hospital de Clinicas de Porto Alegre

Sex: All·Age: 18+

Code: NCT07731048

A Prospective, Randomized Multicenter Clinical Trial of the TricValve® Transcatheter Bicaval Valve System in Subjects With Severe Tricuspid Regurgitation.

for Tricuspid Valve Disease

34 sites incl. Birmingham

Sponsor: P+F Products + Features USA Inc.

Sex: All·Age: 18 - 85

Code: NCT06458907

Early Discharge With Subcutaneous Furosemide Versus Standard Care in Acute Heart Failure

for Heart Failure

2 sites in Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 100

Code: NCT07018297·Phase 3

HS235 Study in Obese Participants With Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction (HFpEF)

for Pulmonary Hypertension

1 site in Greenville

Sponsor: 35Pharma Inc

Sex: All·Age: 18+

Code: NCT07123779·Phase 1, Phase 2

Apply to this trial

SWITCH: Apixaban vs Vitamin K in HM3

for LVAD (Left Ventricular Assist Device) Thrombosis

Sponsor: Columbia University

Sex: All·Age: 18 - 80

Code: NCT07471139·Phase 3

Advancing Clinical Heart Failure Outcomes Leveraging Defibrillation Lead Implant System for Left Bundle Branch Area Pacing

for Heart Failure

Sponsor: Medtronic Cardiac Rhythm and Heart Failure

Sex: All·Age: 18+

Code: NCT07526896

Heart Failure and Postoperative Outcome in Surgery - a National Registry Study

for Heart Failure

Sponsor: Umeå University

Sex: All·Age: 18+

Code: NCT07634822

IV Iron Therapy for Older Adults With Heart Failure With Preserved Ejection Fraction and Iron Deficiency

for Heart Failure With Preserved Ejection Fraction

1 site in Durham

Sponsor: Duke University

Sex: All·Age: 65+

Code: NCT07686692·Phase 4

Arterial Stiffness and Endothelial Function in Heart Failure

for Heart Failure

Sponsor: Coventry University

Sex: All·Age: 18 - 90

Code: NCT07713719

Mobile Health Intervention to Increase Activity in Heart Failure Study

for Heart Failure

1 site in Ann Arbor

Sponsor: University of Michigan

Sex: All·Age: 18+

Code: NCT07750262

Sound Heart Spiritual Combined With Dhikr for Patients With Heart Failure

for Heart Failure

Sponsor: Risqi Wahyu Susanti

Sex: All·Age: 23 - 69

Code: NCT07795632

Effects of a Multidisciplinary Integrated Care Model on Care Outcomes in Patients With Heart Failure With Preserved Ejection Fraction

for Heart Failure With Preserved Ejection Fraction (HFpEF)

Sponsor: Chimei Medical Center

Sex: All·Age: 18+

Code: NCT07798856

Targeted Artificial Intelligence Language mOdel Recommendations for Heart Failure (TAILOR-HF)

for Heart Failure

1 site in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 85

Code: NCT07337577

Apply to this trial

A Study of EDG-15400 in Adults With Heart Failure With Preserved Ejection Fraction (EQUINOX-HFpEF)

for Heart Failure With Preserved Ejection Fraction

25 sites incl. Birmingham

Sponsor: Edgewise Therapeutics, Inc.

Sex: All·Age: 30 - 84

Code: NCT07795814·Phase 2

Apply to this trial

HFrEF Polypill in Sri Lanka RCT

for Heart Failure With Reduced Ejection Fraction

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07569640·Phase 3

Apply to this trial

Medical Large Language Model-Assisted Diagnosis and Treatment in Primary Care Chronic Disease Management

for Coronary Artery Disease

Sponsor: Jiangsu Taizhou People's Hospital

Sex: All·Age: 18 - 65

Code: NCT07740044

Effects of Slow-paced Breathing on Heart Rate Variability in Patients With Heart Failure

for Heart Failure

Sponsor: Chung Shan Medical University

Sex: All·Age: 20 - 80

Code: NCT07763353

STEPwise De-escalation and Optimizing Withdrawal of ARNI and SGLT2i in Normalized Heart Failure

for Heart Failure With Reduced Ejection Fraction

Sponsor: Kyungsub Song

Sex: All·Age: 19+

Code: NCT07631156·Phase 4

Apply to this trial

The Value of a Simple Tool for the Early Detection of Decompensated Heart Failure in People Over 55 on Réunion Island: A Preliminary Study in Hospitals (DEPIST'IC-RUN)

for Heart Failure

Sponsor: Centre Hospitalier Universitaire de la Réunion

Sex: All·Age: 55+

Code: NCT07673562

A Study of LY3971297 in Participants With Heart Failure

for Heart Failure

4 sites incl. Detroit

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 65

Code: NCT07547540·Phase 1

Apply to this trial

MediBeacon® Transdermal GFR System for the Evaluation of Kidney Function in Adults With Heart Failure

for Glomerular Filtration Rate

1 site in New York

Sponsor: MediBeacon

Sex: All·Age: 18+

Code: NCT07349797

Apply to this trial

Incretin Therapies in Obesity-related HFpEF

for Heart Failure, Diastolic

1 site in New York

Sponsor: Columbia University

Sex: All·Age: 40+

Code: NCT07554638·Phase 4

Apply to this trial

Virtual Nurse and Social Worker Palliative Care Team to Improve Quality of Life in Veterans With Heart Failure or COPD

for Heart Failure

7 sites incl. Phoenix

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07714252

Novel Model of Integrated Care of Older Patients With Atrial Fibrillation to Prevent Heart Failure in Rural China

for Atrial Fibrillation

Sponsor: Jiangsu Taizhou People's Hospital

Sex: All·Age: 65 - 80

Code: NCT07492498

Apply to this trial

Novel Model of Integrated Care of Older Patients With Atrial Fibrillation and Heart Failure in Rural China (MIRACLE-AFHF)

for Atrial Fibrillation

Sponsor: Jiangsu Taizhou People's Hospital

Sex: All·Age: 65 - 80

Code: NCT07492524

Apply to this trial

Wearable Assessment of Thoracic, Cardiac Health and Exercise Performance Trial Prospective

for Congenital Heart Disease

Sponsor: The University of Hong Kong

Sex: All·Age: 20 - 70

Code: NCT07663799

Prospective Cohort of Acute Cardiology Referrals in an Ambulatory Day-Hospital Setting

for Acute Coronary Syndromes

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18+

Code: NCT07675434

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Heart failure clinical trials — common questions

Are heart failure clinical trials free to join?

Yes. Participating in a heart failure clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a heart failure clinical trial?

Each heart failure study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a heart failure trial near me?

Use the location controls above. We'll show recruiting heart failure trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many heart failure trials are recruiting right now?

We're currently tracking roughly 274 recruiting heart failure trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Heart failure trials by city

Boston, MA Birmingham, AL Los Angeles, CA Cleveland, OH Chicago, IL Palo Alto, CA Ann Arbor, MI Detroit, MI Stanford, CA Gainesville, FL Salt Lake City, UT Columbus, OH

Related specialties

Cardiology Heart disease