A Cohort for Inflammatory Respiratory Diseases: From Phenotyping to Personalised Medicine

Sponsor
CHU de Reims
Study ID
NCT07274631
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Non applicable — OTHER
    Non applicable

Study Details

Chronic inflammatory pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis, cystic fibrosis (CF), primary ciliary dyskinesia (PCD) and interstitial lung diseases (ILD) are characterised by lung inflammation and remodelling. Clinical, functional, microbiological, biological, pathological and prognostic features are highly variable and heterogeneous. Several phenotypes have been described within the same pathology, as similar phenotypic traits between different pathologies, or the coexistence of components of several diagnoses in the same patient, suggesting shared underlying mechanisms that could represent new therapeutic targets, beyond the initial medical diagnosis. The objectives of this prospective study are to analyze the phenotypic characteristics (clinical, demographic, biological, morphological, pathological, and microbiological characteristics) together with respiratory exposures and underlying mechanisms involving airway epithelium and inflammation processes in a cohort of patients diagnosed with asthma, COPD, bronchiectasis, CF, PCD and ILD.

Key Dates

First listed
Dec 10, 2025
Start date
Sep 15, 2025
Status verified
Feb 2026
Primary completion
Sep 15, 2030
Completion
Sep 15, 2040

Study Design

Enrollment
470 participants (estimated)

Primary Outcome Measure

pheno-endotypes of inflammatory respiratory disease [ Time Frame: Baseline ]

Central Contacts

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